{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:47:23Z","timestamp":1793162843246,"version":"4.5.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:00:00Z","timestamp":1694476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"ASCO Foundation"},{"name":"Young Investigator Award 2022"},{"name":"Tow Center for Developmental Oncology Career Development"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Cancer Institute Cancer Center","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}]},{"DOI":"10.13039\/100007052","name":"Memorial Sloan Kettering Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The rate of esophagogastric cancer is rising among individuals under 50\u00a0years of age. It remains unknown whether early-onset esophagogastric cancer represents a unique entity. This study investigated the clinical and molecular characteristics of early-onset and average-onset esophagogastric cancer .<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We reviewed the Memorial Sloan Kettering Cancer Center gastric, esophageal, and gastroesophageal junction cancer database. Associations between baseline characteristics and tumor and germline molecular alterations were compared between those with early-onset and average-onset esophagogastric cancer using Fisher exact tests and the Benjamini-Hochberg method for multiple-hypothesis correction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 1123 patients with early-onset esophagogastric cancer (n\u2009=\u2009219; median age\u2009=\u200943\u00a0years [range\u2009=\u200918-49\u2009years]) and average-onset esophagogastric cancer (n\u2009=\u2009904; median age\u2009=\u200967\u00a0years [range\u2009=\u200950-94\u2009years]) treated between 2005 and 2018. The early-onset group had more women (39% vs 28%, P\u2009=\u2009.002). Patients with early-onset esophagogastric cancer were more likely to have a gastric primary site (64% vs 44%, P\u2009&amp;lt;\u2009.0001). The\u00a0signet ring cell and\/or diffuse type was 3 times more common in the early-onset esophagogastric cancer group (31% vs 9%, P\u2009&amp;lt;\u2009.0001). Early-onsite tumors were more frequently genomically stable (31% vs 18%, P\u2009=\u2009.0002) and unlikely to be microsatellite instability high (2% vs 7%, P\u2009=\u2009.003). After restricting to adenocarcinoma and\u00a0signet ring cell and\/or diffuse type carcinomas, we observed no difference in stage (P\u2009=\u2009.40) or overall survival from stage IV diagnosis (median\u2009=\u200922.7 vs 22.1\u2009months, P\u2009=\u2009.78).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study supported a preponderance of gastric primary disease sites, signet ring histology, and genomically stable molecular subtypes in early-onset esophagogastric cancer. Our findings highlight the need for further research to define the underlying pathogenesis and strategies for early detection and prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jnci\/djad186","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T13:15:10Z","timestamp":1694524510000},"page":"299-308","source":"Crossref","is-referenced-by-count":45,"title":["Clinical and molecular characteristics of early-onset vs average-onset esophagogastric cancer"],"prefix":"10.1093","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4173-5567","authenticated-orcid":false,"given":"Melissa A","family":"Lumish","sequence":"first","affiliation":[{"name":"Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center , New York, NY, USA"},{"name":"Department of Medicine, Weill Cornell Medical College , New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1188-350X","authenticated-orcid":false,"given":"Henry","family":"Walch","sequence":"additional","affiliation":[{"name":"Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center , New York, NY, USA"},{"name":"Marie-Jos\u00e9e and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center , New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven B","family":"Maron","sequence":"additional","affiliation":[{"name":"Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center , New York, NY, USA"},{"name":"Department of Medicine, Weill Cornell Medical College , New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5474-218X","authenticated-orcid":false,"given":"Walid","family":"Chatila","sequence":"additional","affiliation":[{"name":"Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center , New York, NY, USA"},{"name":"Marie-Jos\u00e9e and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center , New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5042-5651","authenticated-orcid":false,"given":"Yelena","family":"Kemel","sequence":"additional","affiliation":[{"name":"Robert and Kate Niehaus Center for Inherited Cancer Genomics, Memorial Sloan Kettering Cancer Center , New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Maio","sequence":"additional","affiliation":[{"name":"Robert and Kate Niehaus Center for Inherited Cancer Genomics, Memorial Sloan Kettering Cancer Center , New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0448-1038","authenticated-orcid":false,"given":"Geoffrey Y","family":"Ku","sequence":"additional","affiliation":[{"name":"Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center , New York, NY, USA"},{"name":"Department of Medicine, Weill Cornell Medical College , New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0831-2247","authenticated-orcid":false,"given":"David H","family":"Ilson","sequence":"additional","affiliation":[{"name":"Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center , New York, NY, USA"},{"name":"Department of Medicine, Weill Cornell Medical College , New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5901-750X","authenticated-orcid":false,"given":"Elizabeth","family":"Won","sequence":"additional","affiliation":[{"name":"Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center , New York, NY, USA"},{"name":"Department of Medicine, Weill Cornell Medical College , New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Li","sequence":"additional","affiliation":[{"name":"Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center , New York, NY, USA"},{"name":"Department of Medicine, Weill Cornell Medical College , New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smita S","family":"Joshi","sequence":"additional","affiliation":[{"name":"Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center , New York, NY, USA"},{"name":"Department of Medicine, Weill Cornell Medical College , New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Gu","sequence":"additional","affiliation":[{"name":"Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center , New York, NY, USA"},{"name":"Department of Medicine, Weill Cornell Medical College , New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A","family":"Schattner","sequence":"additional","affiliation":[{"name":"Gastroenterology, Hepatology and Nutrition Service, Department of Medicine, Memorial Sloan Kettering Cancer Center , New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6816-3293","authenticated-orcid":false,"given":"Monika","family":"Laszkowska","sequence":"additional","affiliation":[{"name":"Gastroenterology, Hepatology and Nutrition Service, Department of Medicine, Memorial Sloan Kettering Cancer Center , New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Gerdes","sequence":"additional","affiliation":[{"name":"Gastroenterology, Hepatology and Nutrition Service, Department of Medicine, Memorial Sloan Kettering Cancer Center , New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Surgery Memorial, Sloan Kettering Cancer Center , New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smita","family":"Sihag","sequence":"additional","affiliation":[{"name":"Department of Surgery Memorial, Sloan Kettering Cancer Center , New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8901-1555","authenticated-orcid":false,"given":"Daniel G","family":"Coit","sequence":"additional","affiliation":[{"name":"Department of Surgery Memorial, Sloan Kettering Cancer Center , New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura H","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Memorial Sloan Kettering Cancer Center , New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian E","family":"Strong","sequence":"additional","affiliation":[{"name":"Department of Surgery Memorial, Sloan Kettering Cancer Center , New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Molena","sequence":"additional","affiliation":[{"name":"Department of Surgery Memorial, Sloan Kettering Cancer Center , New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsofia K","family":"Stadler","sequence":"additional","affiliation":[{"name":"Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center , New York, NY, USA"},{"name":"Department of Medicine, Weill Cornell Medical College , New York, NY, USA"},{"name":"Robert and Kate Niehaus Center for Inherited Cancer Genomics, Memorial Sloan Kettering Cancer Center , New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaus","family":"Schultz","sequence":"additional","affiliation":[{"name":"Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center , New York, NY, USA"},{"name":"Marie-Jos\u00e9e and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center , New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yelena Y","family":"Janjigian","sequence":"additional","affiliation":[{"name":"Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center , New York, NY, USA"},{"name":"Department of Medicine, Weill Cornell Medical College , New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5054-8192","authenticated-orcid":false,"given":"Andrea","family":"Cercek","sequence":"additional","affiliation":[{"name":"Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center , New York, NY, USA"},{"name":"Department of Medicine, Weill Cornell Medical College , New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,9,12]]},"reference":[{"key":"2024020820195053100_djad186-B1","author":"Howlader","year":"2019"},{"issue":"3","key":"2024020820195053100_djad186-B2","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.cgh.2018.05.044","article-title":"Incidence trends of esophageal and gastric cancer subtypes by race, ethnicity, and age in the United States, 1997\u20132014","volume":"17","author":"Islami","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"6","key":"2024020820195053100_djad186-B3","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"issue":"8","key":"2024020820195053100_djad186-B4","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1002\/ijc.31937","article-title":"Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods","volume":"144","author":"Ferlay","year":"2019","journal-title":"Int J Cancer"},{"issue":"7","key":"2024020820195053100_djad186-B5","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.14753","article-title":"Prevalence of germline alterations on targeted tumor-normal sequencing of esophagogastric cancer","volume":"4","author":"Ku","year":"2021","journal-title":"JAMA Netw Open"},{"issue":"13","key":"2024020820195053100_djad186-B6","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.3390\/cancers13133132","article-title":"Clinical, molecular and genetic characteristics of early onset gastric cancer: analysis of a large multicenter study","volume":"13","author":"Pocurull","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"3","key":"2024020820195053100_djad186-B7","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1001\/jama.2009.2014","article-title":"Prevalence and trends in obesity among US adults, 1999-2008","volume":"303","author":"Flegal","year":"2010","journal-title":"JAMA"},{"issue":"4","key":"2024020820195053100_djad186-B8","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1001\/jama.289.4.450","article-title":"Patterns and trends in food portion sizes, 1977-1998","volume":"289","author":"Nielsen","year":"2003","journal-title":"JAMA"},{"issue":"8","key":"2024020820195053100_djad186-B9","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1007\/s10620-008-0565-7","article-title":"Presentation and prognosis of esophageal adenocarcinoma in patients below age 50","volume":"54","author":"Hashemi","year":"2009","journal-title":"Dig Dis Sci"},{"issue":"4","key":"2024020820195053100_djad186-B10","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1593\/neo.101722","article-title":"Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma","volume":"13","author":"Wu","year":"2011","journal-title":"Neoplasia"},{"issue":"4","key":"2024020820195053100_djad186-B11","first-page":"547","article-title":"Early-onset gastric cancer is a distinct disease with worrisome trends and oncogenic features","volume":"166","author":"Bergquist","year":"2019","journal-title":"Surgery (United States)"},{"issue":"4","key":"2024020820195053100_djad186-B12","doi-asserted-by":"crossref","first-page":"238","DOI":"10.5230\/jgc.2014.14.4.238","article-title":"Impact of age on clinicopathological features and survival of patients with noncardia gastric adenocarcinoma","volume":"14","author":"Bautista","year":"2014","journal-title":"J. Gastric Cancer"},{"issue":"4","key":"2024020820195053100_djad186-B13","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1007\/s00268-010-0407-6","article-title":"Presentation and survival of operable esophageal cancer in patients 55 years of age and below","volume":"34","author":"Hamouda","year":"2010","journal-title":"World J Surg"},{"issue":"16","key":"2024020820195053100_djad186-B14","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1093\/jnci\/djn211","article-title":"Incidence of adenocarcinoma of the esophagus among white Americans by sex, stage, and age","volume":"100","author":"Brown","year":"2008","journal-title":"J Natl Cancer Inst"},{"issue":"6","key":"2024020820195053100_djad186-B15","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.gie.2012.01.011","article-title":"Appropriate use of GI endoscopy","volume":"75","author":"Early","year":"2012","journal-title":"Gastrointest Endosc"},{"issue":"1","key":"2024020820195053100_djad186-B16","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.semradonc.2006.09.003","article-title":"Epidemiology and pathogenesis of esophageal cancer","volume":"17","author":"Holmes","year":"2007","journal-title":"Semin Radiat Oncol"},{"issue":"3","key":"2024020820195053100_djad186-B17","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jmoldx.2014.12.006","article-title":"Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT): a hybridization capture-based next-generation sequencing clinical assay for solid tumor. Molecular Oncology","volume":"17","author":"Cheng","year":"2015","journal-title":"J Mol Diagn"},{"issue":"6","key":"2024020820195053100_djad186-B18","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nm.4333","article-title":"Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients","volume":"23","author":"Zehir","year":"2017","journal-title":"Nat Med"},{"key":"2024020820195053100_djad186-B19","first-page":"1","article-title":"OncoKB: a precision oncology knowledge base","volume":"1","author":"Chakravarty","year":"2017","journal-title":"J Clin Oncol Precis. Oncol"},{"issue":"2","key":"2024020820195053100_djad186-B20","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.cell.2018.03.035","article-title":"Oncogenic signaling pathways in the cancer genome atlas","volume":"173","author":"Sanchez-Vega","year":"2018","journal-title":"Cell"},{"issue":"7517","key":"2024020820195053100_djad186-B21","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/nature13480","article-title":"Comprehensive molecular characterization of gastric adenocarcinoma","volume":"513","author":"Bass","year":"2014","journal-title":"Nature"},{"issue":"33","key":"2024020820195053100_djad186-B22","first-page":"1","article-title":"Comprehensive detection of germline variants by MSK-IMPACT, a clinical diagnostic platform for solid tumor molecular oncology and concurrent cancer predisposition testing","volume":"10","author":"Cheng","year":"2017","journal-title":"BMC Med Genomics"},{"key":"2024020820195053100_djad186-B23","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1200\/JCO.2021.39.3_suppl.250","article-title":"Clinical and molecular characteristics of early-onset versus average-onset esophagogastric cancer","volume-title":"J Clin Oncol","author":"Lumish","year":"2021"},{"issue":"22","key":"2024020820195053100_djad186-B24","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13225628","article-title":"Gastric cancers missed at upper endoscopy in central Norway 2007 to 2016\u2014a population-based study","volume":"13","author":"Beck","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"6052","key":"2024020820195053100_djad186-B25","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1126\/science.1208344","article-title":"Linking long-term dietary patterns with gut microbial enterotypes","volume":"334","author":"Wu","year":"2011","journal-title":"Science"},{"issue":"4","key":"2024020820195053100_djad186-B26","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/sj.bjc.6605517","article-title":"Oestrogen receptor-\u03b1 contributes to the regulation of the hedgehog signalling pathway in ER\u03b1-positive gastric cancer","volume":"102","author":"Kameda","year":"2010","journal-title":"Br J Cancer"},{"issue":"2","key":"2024020820195053100_djad186-B27","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0304-3835(01)00739-X","article-title":"Expression of estrogen receptor-\u03b1 and -\u03b2 mRNAs in human gastric cancer","volume":"176","author":"Takano","year":"2002","journal-title":"Cancer Lett"},{"issue":"9","key":"2024020820195053100_djad186-B28","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1245\/s10434-010-1031-2","article-title":"Prognostic role of estrogen receptor alpha and estrogen receptor beta in gastric cancer","volume":"17","author":"Xu","year":"2010","journal-title":"Ann Surg Oncol"},{"issue":"2","key":"2024020820195053100_djad186-B29","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ejso.2006.09.009","article-title":"Altered expression of estrogen receptor alpha and beta in advanced gastric adenocarcinoma: Correlation with prothymosin alpha and clinicopathological parameters","volume":"33","author":"Wang","year":"2007","journal-title":"Eur J Surg Oncol"},{"issue":"4","key":"2024020820195053100_djad186-B30","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/jso.23097","article-title":"Expression of estrogen receptors in gastric cancer and their clinical significance","volume":"106","author":"Ryu","year":"2012","journal-title":"J Surg Oncol"},{"issue":"4","key":"2024020820195053100_djad186-B31","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1007\/s10120-022-01290-0","article-title":"Tumorigenic mechanisms of estrogen and Helicobacter pylori cytotoxin-associated gene A in estrogen receptor \u03b1-positive diffuse-type gastric adenocarcinoma","volume":"25","author":"Kang","year":"2022","journal-title":"Gastric Cancer"},{"issue":"2","key":"2024020820195053100_djad186-B32","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1080\/01635581.2017.1263750","article-title":"Intestinal proportion of Blautia sp. is associated with clinical stage and histoprognostic grade in patients with early-stage breast cancer","volume":"69","author":"Luu","year":"2017","journal-title":"Nutr Cancer"},{"issue":"3","key":"2024020820195053100_djad186-B33","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.gie.2011.05.001","article-title":"Endoscopy for upper GI cancer screening in the general population: a cost-utility analysis","volume":"74","author":"Gupta","year":"2011","journal-title":"Gastrointest. Endosc"},{"issue":"8","key":"2024020820195053100_djad186-B34","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/onco.13849","article-title":"A coordinated clinical center for young onset colorectal cancer","volume":"26","author":"Mendelsohn","year":"2021","journal-title":"Oncologist"},{"issue":"24","key":"2024020820195053100_djad186-B35","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1200\/JCO.21.02708","article-title":"Practical considerations in diagnosing and managing early-onset GI cancers","volume":"40","author":"Lumish","year":"2022","journal-title":"J Clin Oncol"}],"container-title":["JNCI: Journal of the National Cancer Institute"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jnci\/advance-article-pdf\/doi\/10.1093\/jnci\/djad186\/53271369\/djad186.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jnci\/article-pdf\/116\/2\/299\/56626163\/djad186.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jnci\/article-pdf\/116\/2\/299\/56626163\/djad186.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T15:20:42Z","timestamp":1707405642000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnci\/article\/116\/2\/299\/7271189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,12]]},"references-count":35,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,9,12]]},"published-print":{"date-parts":[[2024,2,8]]}},"URL":"https:\/\/doi.org\/10.1093\/jnci\/djad186","relation":{},"ISSN":["0027-8874","1460-2105"],"issn-type":[{"value":"0027-8874","type":"print"},{"value":"1460-2105","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,2,1]]},"published":{"date-parts":[[2023,9,12]]}}}