{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T10:01:01Z","timestamp":1772532061400,"version":"3.50.1"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T00:00:00Z","timestamp":1695600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100006093","name":"Patient-Centered Outcomes Research Institute","doi-asserted-by":"publisher","award":["PCS-1504-30370"],"award-info":[{"award-number":["PCS-1504-30370"]}],"id":[{"id":"10.13039\/100006093","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Breast Cancer Surveillance Consortium"},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P01CA154292"],"award-info":[{"award-number":["P01CA154292"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U54CA163303"],"award-info":[{"award-number":["U54CA163303"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000133","name":"Agency for Health Research and Quality","doi-asserted-by":"crossref","award":["R01 HS018366-01A1"],"award-info":[{"award-number":["R01 HS018366-01A1"]}],"id":[{"id":"10.13039\/100000133","id-type":"DOI","asserted-by":"crossref"}]},{"name":"University of Vermont Cancer Center"},{"DOI":"10.13039\/100015187","name":"Lake Champlain Cancer Research Organization","doi-asserted-by":"publisher","award":["#032800"],"award-info":[{"award-number":["#032800"]}],"id":[{"id":"10.13039\/100015187","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Examining screening outcomes by breast density for breast magnetic resonance imaging (MRI) with or without mammography could inform discussions about supplemental MRI in women with dense breasts.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We evaluated 52\u200a237 women aged 40-79 years who underwent 2611 screening MRIs alone and 6518 supplemental MRI plus mammography pairs propensity score\u2013matched to 65\u200a810 screening mammograms. Rates per 1000 examinations of interval, advanced, and screen-detected early stage invasive cancers and false-positive recall and biopsy recommendation were estimated by breast density (nondense = almost entirely fatty or scattered fibroglandular densities; dense = heterogeneously\/extremely dense) adjusting for registry, examination year, age, race and ethnicity, family history of breast cancer, and prior breast biopsy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Screen-detected early stage cancer rates were statistically higher for MRI plus mammography vs mammography for nondense (9.3 vs 2.9; difference\u2009=\u20096.4, 95% confidence interval [CI]\u2009=\u20092.5 to 10.3) and dense (7.5 vs 3.5; difference\u2009=\u20094.0, 95% CI\u2009=\u20091.4 to 6.7) breasts and for MRI vs MRI plus mammography for dense breasts (19.2 vs 7.5; difference\u2009=\u200911.7, 95% CI\u2009=\u20094.6 to 18.8). Interval rates were not statistically different for MRI plus mammography vs mammography for nondense (0.8 vs 0.5; difference\u2009=\u20090.4, 95% CI\u2009=\u2009-0.8 to 1.6) or dense breasts (1.5 vs 1.4; difference\u2009=\u20090.0, 95% CI\u2009=\u2009-1.2 to 1.3), nor were advanced cancer rates. Interval rates were not statistically different for MRI vs MRI plus mammography for nondense (2.6 vs 0.8; difference\u2009=\u20091.8 (95% CI\u2009=\u2009-2.0 to 5.5) or dense breasts (0.6 vs 1.5; difference\u2009=\u2009-0.9, 95% CI\u2009=\u2009-2.5 to 0.7), nor were advanced cancer rates. False-positive recall and biopsy recommendation rates were statistically higher for MRI groups than mammography alone.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>MRI screening with or without mammography increased rates of screen-detected early stage cancer and false-positives for women with dense breasts without a concomitant decrease in advanced or interval cancers.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jnci\/djad201","type":"journal-article","created":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T05:44:46Z","timestamp":1698471886000},"page":"249-257","source":"Crossref","is-referenced-by-count":13,"title":["Supplemental magnetic resonance imaging plus mammography compared with magnetic resonance imaging or mammography by extent of breast density"],"prefix":"10.1093","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8793-8779","authenticated-orcid":false,"given":"Karla","family":"Kerlikowske","sequence":"first","affiliation":[{"name":"Departments of Medicine and Epidemiology and Biostatistics, University of California , San Francisco, CA, USA"},{"name":"General Internal Medicine Section, Department of Veterans Affairs, University of California , San Francisco, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington , Seattle, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Ru","family":"Su","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington , Seattle, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian L","family":"Sprague","sequence":"additional","affiliation":[{"name":"Departments of Surgery and Radiology, University of Vermont , Burlington, VT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha K","family":"Stout","sequence":"additional","affiliation":[{"name":"Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute , Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy","family":"Onega","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences, University of Utah, Huntsman Cancer Institute , Salt Lake City, UT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen S","family":"O\u2019Meara","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington , Seattle, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise M","family":"Henderson","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of North Carolina , Chapel Hill, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna N A","family":"Tosteson","sequence":"additional","affiliation":[{"name":"The Dartmouth Institute for Health Policy and Clinical Practice and Dartmouth Cancer Center, Geisel School of Medicine at Dartmouth , Lebanon, NH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Wernli","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington , Seattle, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana L","family":"Miglioretti","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington , Seattle, WA, USA"},{"name":"Department of Public Health Sciences, University of California , Davis, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,9,25]]},"reference":[{"issue":"10","key":"2024020820182539500_djad201-B1","doi-asserted-by":"crossref","first-page":"dju255","DOI":"10.1093\/jnci\/dju255","article-title":"Prevalence of mammographically dense breasts in the United States","volume":"106","author":"Sprague","year":"2014","journal-title":"J Natl Cancer Inst"},{"issue":"10","key":"2024020820182539500_djad201-B2","doi-asserted-by":"crossref","first-page":"673","DOI":"10.7326\/M14-1465","article-title":"Identifying women with dense breasts at high risk for interval cancer: a cohort study","volume":"162","author":"Kerlikowske","year":"2015","journal-title":"Ann Intern Med"},{"issue":"14","key":"2024020820182539500_djad201-B3","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.1002\/cncr.32939","article-title":"New mammography screening performance metrics based on the entire screening episode","volume":"126","author":"Sprague","year":"2020","journal-title":"Cancer"},{"issue":"3","key":"2024020820182539500_djad201-B4","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1148\/radiol.2020200240","article-title":"Multicenter evaluation of breast cancer screening with digital breast tomosynthesis in combination with synthetic versus digital mammography","volume":"297","author":"Zuckerman","year":"2020","journal-title":"Radiology"},{"key":"2024020820182539500_djad201-B5","author":"Food and Drug Administration","year":"2023"},{"issue":"3 Pt A","key":"2024020820182539500_djad201-B6","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.jacr.2017.11.034","article-title":"Breast cancer screening in women at higher-than-average risk: recommendations from the ACR","volume":"15","author":"Monticciolo","year":"2018","journal-title":"J Am Coll Radiol"},{"issue":"2","key":"2024020820182539500_djad201-B7","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2214\/AJR.20.24436","article-title":"Screening algorithms in dense breasts: AJR expert panel narrative review","volume":"216","author":"Berg","year":"2021","journal-title":"AJR Am J Roentgenol"},{"issue":"4","key":"2024020820182539500_djad201-B8","doi-asserted-by":"crossref","first-page":"279","DOI":"10.7326\/M15-2886","article-title":"Screening for breast cancer: U.S. Preventive Servies Task Force recommendation statement","volume":"164","author":"Siu","year":"2016","journal-title":"Ann Intern Med"},{"issue":"8","key":"2024020820182539500_djad201-B9","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/S1470-2045(19)30275-X","article-title":"MRI versus mammography for breast cancer screening in women with familial risk (FaMRIsc): a multicentre, randomised, controlled trial","volume":"20","author":"Saadatmand","year":"2019","journal-title":"Lancet Oncol"},{"issue":"2","key":"2024020820182539500_djad201-B10","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1093\/jnci\/djz079","article-title":"Performance measures of magnetic resonance imaging plus mammography in the high risk Ontario breast screening program","volume":"112","author":"Chiarelli","year":"2020","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"2024020820182539500_djad201-B11","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1148\/radiol.2016161444","article-title":"Supplemental breast MR imaging screening of women with average risk of breast cancer","volume":"283","author":"Kuhl","year":"2017","journal-title":"Radiology"},{"issue":"22","key":"2024020820182539500_djad201-B12","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1056\/NEJMoa1903986","article-title":"Supplemental MRI screening for women with extremely dense breast tissue","volume":"381","author":"Bakker","year":"2019","journal-title":"N Engl J Med"},{"issue":"4","key":"2024020820182539500_djad201-B13","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.2214\/ajr.169.4.9308451","article-title":"Breast Cancer Surveillance Consortium: a national mammography screening and outcomes database","volume":"169","author":"Ballard-Barbash","year":"1997","journal-title":"AJR Am J Roentgenol"},{"issue":"7","key":"2024020820182539500_djad201-B14","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1001\/jama.2020.9151","article-title":"Immortal time bias in observational studies","volume":"325","author":"Yadav","year":"2021","journal-title":"JAMA"},{"key":"2024020820182539500_djad201-B15","volume-title":"AJCC Cancer Staging Manual","author":"Hortobagyi","year":"2016"},{"issue":"7","key":"2024020820182539500_djad201-B16","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1093\/jnci\/djaa176","article-title":"Advanced breast cancer definitions by staging system examined in the Breast Cancer Surveillance Consortium","volume":"113","author":"Kerlikowske","year":"2021","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"2024020820182539500_djad201-B17","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1148\/radiol.2342040048","article-title":"Association between mammography timing and measures of screening performance in the U","volume":"234","author":"Yankaskas","year":"2005","journal-title":"S. Radiology"},{"key":"2024020820182539500_djad201-B18","author":"American College of Radiology","year":"2013"},{"issue":"3","key":"2024020820182539500_djad201-B19","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1080\/00273171.2011.568786","article-title":"An introduction to propensity score methods for reducing the effects of confounding in observational studies","volume":"46","author":"Austin","year":"2011","journal-title":"Multivariate Behav Res"},{"issue":"3","key":"2024020820182539500_djad201-B20","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1093\/biostatistics\/kxg042","article-title":"Marginal modeling of multilevel binary data with time varying covariates","volume":"5","author":"Miglioretti","year":"2004","journal-title":"Biostatistics"},{"issue":"4","key":"2024020820182539500_djad201-B21","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1093\/aje\/kwk020","article-title":"Marginal modeling of nonnested multilevel data using standard software","volume":"165","author":"Miglioretti","year":"2007","journal-title":"Am J Epidemiol"},{"issue":"1","key":"2024020820182539500_djad201-B22","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/biomet\/73.1.13","article-title":"Longitudinal data analysis using generalized linear models","volume":"73","author":"Liang","year":"1986","journal-title":"Biometrika"},{"issue":"1","key":"2024020820182539500_djad201-B23","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1177\/1740774510392256","article-title":"Adjusted intraclass correlation coefficients for binary data: Methods and estimates from a cluster-randomized trial in primary care","volume":"8","author":"Yelland","year":"2011","journal-title":"Clin Trials"},{"issue":"4","key":"2024020820182539500_djad201-B24","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1111\/j.1541-0420.2005.00377.x","article-title":"Doubly robust estimation in missing data and causal inference models","volume":"61","author":"Bang","year":"2005","journal-title":"Biometrics"},{"issue":"3","key":"2024020820182539500_djad201-B25","first-page":"962","article-title":"Estimating predicted probabilities from logistic regression: different methods correspond to different target populations","volume":"43","author":"Muller","year":"2014","journal-title":"In J Epidemiol"},{"issue":"4","key":"2024020820182539500_djad201-B26","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1001\/jamainternmed.2017.8549","article-title":"Breast biopsy intensity and findings following breast cancer screening in women with and without a personal history of breast cancer","volume":"178","author":"Buist","year":"2018","journal-title":"JAMA Intern Med"},{"issue":"4","key":"2024020820182539500_djad201-B27","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.clbc.2021.03.006","article-title":"Diagnostic performance of adjunctive imaging modalities compared to mammography alone in women with non-dense and dense breasts: a systematic review and meta-analysis","volume":"21","author":"Hadadi","year":"2021","journal-title":"Clin Breast Cancer"},{"issue":"1","key":"2024020820182539500_djad201-B28","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1245\/s10434-022-12568-z","article-title":"Screening MRI does not increase cancer detection or result in an earlier stage at diagnosis for patients with high-risk breast lesions: a propensity score analysis","volume":"30","author":"Laws","year":"2023","journal-title":"Ann Surg Oncol"},{"issue":"2","key":"2024020820182539500_djad201-B29","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1148\/radiol.2021203633","article-title":"Supplemental breast MRI for women with extremely dense breasts: results of the second screening round of the DENSE Trial","volume":"299","author":"Veenhuizen","year":"2021","journal-title":"Radiology"},{"issue":"13","key":"2024020820182539500_djad201-B30","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1200\/JCO.2009.27.0835","article-title":"Prospective study of breast cancer incidence in women with a BRCA1 or BRCA2 mutation under surveillance with and without magnetic resonance imaging","volume":"29","author":"Warner","year":"2011","journal-title":"J Clin Oncol"},{"issue":"3","key":"2024020820182539500_djad201-B31","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.clbc.2021.09.011","article-title":"The effect of supplemental imaging on interval cancer rates in mammography screening: Systematic review","volume":"22","author":"Zeng","year":"2022","journal-title":"Clin Breast Cancer"},{"key":"2024020820182539500_djad201-B32","doi-asserted-by":"crossref","first-page":"110416","DOI":"10.1016\/j.ejrad.2022.110416","article-title":"Examining the effectiveness of supplementary imaging modalities for breast cancer screening in women with dense breasts: A systematic review and meta-analysis","volume":"154","author":"Mizzi","year":"2022","journal-title":"Eur J Radiol"},{"issue":"4","key":"2024020820182539500_djad201-B33","doi-asserted-by":"crossref","first-page":"e227234","DOI":"10.1001\/jamanetworkopen.2022.7234","article-title":"Downstream mammary and extramammary cascade services and spending following screening breast magnetic resonance imaging vs mammography among commercially insured women","volume":"5","author":"Ganguli","year":"2022","journal-title":"JAMA Netw Open"},{"issue":"11","key":"2024020820182539500_djad201-B34","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1093\/jnci\/djab119","article-title":"Cost-effectiveness of magnetic resonance imaging screening for women with extremely dense breast tissue","volume":"113","author":"Geuzinge","year":"2021","journal-title":"J Natl Cancer Inst"},{"issue":"3","key":"2024020820182539500_djad201-B35","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s10549-014-2931-9","article-title":"MRI breast screening in high-risk women: Cancer detection and survival analysis","volume":"145","author":"Gareth","year":"2014","journal-title":"Breast Cancer Res Treat"},{"issue":"3","key":"2024020820182539500_djad201-B36","doi-asserted-by":"crossref","first-page":"e221785","DOI":"10.1148\/radiol.221785","article-title":"Supplemental breast cancer screening in women with dense breasts and negative mammography: a systematic review and meta-analysis","volume":"306","author":"Hussein","year":"2023","journal-title":"Radiology"},{"issue":"8","key":"2024020820182539500_djad201-B37","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1001\/jama.2020.0572","article-title":"Comparison of abbreviated breast MRI vs digital breast tomosynthesis for breast cancer detection among women with dense breasts undergoing screening","volume":"323","author":"Comstock","year":"2020","journal-title":"JAMA"},{"issue":"33","key":"2024020820182539500_djad201-B38","doi-asserted-by":"crossref","first-page":"3874","DOI":"10.1200\/JCO.19.02198","article-title":"Abbreviated breast magnetic resonance imaging for supplemental screening of women with dense breasts and average risk","volume":"38","author":"Weinstein","year":"2020","journal-title":"J Clin Oncol"}],"container-title":["JNCI: Journal of the National Cancer Institute"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jnci\/advance-article-pdf\/doi\/10.1093\/jnci\/djad201\/52635055\/djad201.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jnci\/article-pdf\/116\/2\/249\/56626071\/djad201.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jnci\/article-pdf\/116\/2\/249\/56626071\/djad201.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T20:19:01Z","timestamp":1707423541000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnci\/article\/116\/2\/249\/7331237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,25]]},"references-count":38,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,9,25]]},"published-print":{"date-parts":[[2024,2,8]]}},"URL":"https:\/\/doi.org\/10.1093\/jnci\/djad201","relation":{},"ISSN":["0027-8874","1460-2105"],"issn-type":[{"value":"0027-8874","type":"print"},{"value":"1460-2105","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,2,1]]},"published":{"date-parts":[[2023,9,25]]}}}