{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:24:03Z","timestamp":1791257043923,"version":"4.1.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T00:00:00Z","timestamp":1696550400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000038","name":"Food and Drug Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008935","name":"Center of Excellence in Regulatory Science and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008935","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Yale University and Mayo Clinic","award":["U01FD005938"],"award-info":[{"award-number":["U01FD005938"]}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The impact of ongoing efforts to decrease opioid use on patients with cancer remains undefined. Our objective was to determine trends in new and additional opioid use in patients with and without cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study used data from Surveillance, Epidemiology, and End Results program\u2013Medicare for opioid-naive patients with solid tumor malignancies diagnosed from 2012 through 2017 and a random sample of patients without cancer. We identified 238\u200a470 eligible patients with cancer and further focused on 4 clinical strata: patients without cancer, patients with metastatic cancer, patients with nonmetastatic cancer treated with surgery alone (\u201csurgery alone\u201d), and patients with nonmetastatic cancer treated with surgery plus chemotherapy or radiation therapy (\u201csurgery+\u201d). We identified new, early additional, and long-term additional opioid use and calculated the change in predicted probability of these outcomes from 2012 to 2017.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>New opioid use was higher in patients with cancer (46.4%) than in those without (6.9%) (P\u2009&amp;lt;\u2009.001). From 2012 to 2017, the predicted probability of new opioid use was more stable in the cancer strata (relative declines: 0.1% surgery alone; 2.4% surgery+; 8.8% metastatic cancer), than in the noncancer stratum (20.0%) (P\u2009&amp;lt;\u2009.001 for each cancer to noncancer comparison). Early additional use declined among surgery patients (\u201214.9% and \u201217.5% for surgery alone and surgery+, respectively) but was stable among patients with metastatic disease (\u20122.8%, P\u2009=\u2009.50).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Opioid prescribing declined over time at a slower rate in patients with cancer than in patients without cancer. Our study suggests important but tempered effects of the changing opioid climate on patients with cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jnci\/djad206","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T16:04:19Z","timestamp":1695744259000},"page":"316-323","source":"Crossref","is-referenced-by-count":13,"title":["Trends in new and persistent opioid use in older adults with and without cancer"],"prefix":"10.1093","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4853-6213","authenticated-orcid":false,"given":"Laura Van Metre","family":"Baum","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Yale School of Medicine , New Haven, CT,","place":["USA"]},{"name":"Cancer Outcomes, Public Policy and Effectiveness Research Center, Yale School of Medicine , New Haven, 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MN,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6298-332X","authenticated-orcid":false,"given":"Kathryn J","family":"Ruddy","sequence":"additional","affiliation":[{"name":"Department of Oncology, Mayo Clinic , Rochester, MN,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine C","family":"Lerro","sequence":"additional","affiliation":[{"name":"Oncology Center of Excellence, US Food and Drug Administration , Silver Spring, MD,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"Lee","sequence":"additional","affiliation":[{"name":"Office of Biostatistics, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration , Silver Spring, MD,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David 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CT,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6602-7204","authenticated-orcid":false,"given":"Vikram","family":"Jairam","sequence":"additional","affiliation":[{"name":"Cancer Outcomes, Public Policy and Effectiveness Research Center, Yale School of Medicine , New Haven, CT,","place":["USA"]},{"name":"Department of Therapeutic Radiology, Yale School of Medicine , New Haven, CT,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4849-4743","authenticated-orcid":false,"given":"Michaela A","family":"Dinan","sequence":"additional","affiliation":[{"name":"Cancer Outcomes, Public Policy and Effectiveness Research Center, Yale School of Medicine , New Haven, CT,","place":["USA"]},{"name":"Department of Chronic Disease Epidemiology, Yale School of Public Health , New Haven, CT,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cary 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