{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T09:18:28Z","timestamp":1793870308714,"version":"4.6.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Italian Association for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["MFAG 2020"],"award-info":[{"award-number":["MFAG 2020"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["24698"],"award-info":[{"award-number":["24698"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>The addition of taxanes to anthracycline-based chemotherapy is considered standard of care in the treatment of breast cancer. However, there are insufficient data regarding the safety of taxanes during pregnancy. The aim of this study was to describe the incidence of obstetric and neonatal adverse events associated with the use of taxane-containing chemotherapy regimens for the treatment of breast cancer during pregnancy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This is a multicenter, international cohort study of breast cancer patients treated with taxanes during pregnancy. A descriptive analysis was undertaken to synthetize available data.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 103 patients were included, most of whom were treated with paclitaxel and anthracyclines given in sequence during gestation (90.1%). The median gestational age at taxane initiation was 28\u2009weeks (range = 12-37 weeks). Grade 3-4 adverse events were reported in 7 of 103 (6.8%) patients. The most common reported obstetric complications were intrauterine growth restriction (n\u2009=\u20098 of 94, 8.5%) and preterm premature rupture of membranes (n\u2009=\u20095 of 94, 5.3%). The live birth rate was 92 of 94 (97.9%), and the median gestational age at delivery was 37\u2009weeks (range = 32-40 weeks). Admission to an intensive care unit was reported in 14 of 88 (15.9%) neonates, and 17 of 70 (24.3%) live births resulted in small for gestational age neonates. Congenital malformations were reported in 2 of 93 (2.2%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Obstetric and neonatal outcomes after taxane exposure during pregnancy were generally favorable and did not seem to differ from those reported in the literature with standard anthracycline-based regimens. This study supports the use of taxanes during gestation when clinically indicated.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jnci\/djad219","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T18:11:07Z","timestamp":1701972667000},"page":"239-248","source":"Crossref","is-referenced-by-count":17,"title":["Taxanes for the treatment of breast cancer during pregnancy: an international cohort study"],"prefix":"10.1093","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1855-1196","authenticated-orcid":false,"given":"Ana S","family":"Ferrigno Guajardo","sequence":"first","affiliation":[{"name":"Department of Medicine, Yale University School of Medicine , New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan F","family":"Vaca-Cartagena","sequence":"additional","affiliation":[{"name":"Breast Cancer Center, Hospital Zambrano Hellion, Tecnologico de Monterrey , San Pedro Garza Garcia, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica L","family":"Mayer","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute , Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chayma","family":"Bousrih","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Gustave Roussy , Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oke","family":"Oluchi","sequence":"additional","affiliation":[{"name":"Department of General Oncology and Breast Medical Oncology, The University of Texas MD Anderson Cancer Center , Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Saura","sequence":"additional","affiliation":[{"name":"Medical Oncology Service, Vall d\u2019Hebron University Hospital and Vall d\u2019Hebron Institute of Oncology , Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8227-8740","authenticated-orcid":false,"given":"Fedro","family":"Peccatori","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Program, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) European Institute of Oncology , Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2269-2354","authenticated-orcid":false,"given":"Wendy","family":"Mu\u00f1oz-Monta\u00f1o","sequence":"additional","affiliation":[{"name":"Clinica de Tumores Mamarios, Instituto Nacional de Cancerolog\u00eda , Ciudad de Mexico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Cabrera-Garcia","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, Hospital Regional de Alta Especialidad de Ixtapaluca , Ixtapaluca, State of Mexico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1797-5296","authenticated-orcid":false,"given":"Matteo","family":"Lambertini","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Specialties, School of Medicine, University of Genova , Genova, Italy"},{"name":"Department of Medical Oncology, U.O. 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