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To address the lack of clinical trial evidence to guide health-related social needs interventions among cancer patients, the National Cancer Institute Cancer Care Delivery Research Steering Committee convened experts to participate in a clinical trials planning meeting with the goal of designing studies to screen for and address health-related social needs among cancer patients.<\/jats:p>\n               <jats:p>In this commentary, we discuss the rationale for, and challenges of, designing and testing health-related social needs interventions in alignment with the National Academy of Sciences, Engineering, and Medicine 5As framework. Evidence for food, housing, utilities, interpersonal safety, and transportation health-related social needs interventions is analyzed. Evidence regarding health-related social needs and delivery of health-related social needs interventions differs in maturity and applicability to cancer context, with transportation problems having the most maturity and interpersonal safety the least. We offer practical recommendations for health-related social needs interventions among cancer patients and the caregivers, families, and friends who support their health-related social needs. Cross-cutting (ie, health-related social needs agnostic) recommendations include leveraging navigation (eg, people, technology) to identify, refer, and deliver health-related social needs interventions; addressing health-related social needs through multilevel interventions; and recognizing that health-related social needs are states, not traits, that fluctuate over time. Health-related social needs\u2013specific interventions are recommended, and pros and cons of addressing more than one health-related social needs concurrently are characterized. Considerations for collaborating with community partners are highlighted. The need for careful planning, strong partners, and funding is stressed. Finally, we outline a future research agenda to address evidence gaps.<\/jats:p>","DOI":"10.1093\/jnci\/djad269","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T18:13:07Z","timestamp":1704391987000},"page":"497-505","source":"Crossref","is-referenced-by-count":26,"title":["Interventions addressing health-related social needs among patients with cancer"],"prefix":"10.1093","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3766-468X","authenticated-orcid":false,"given":"Evan M","family":"Graboyes","sequence":"first","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina , Charleston, SC,","place":["USA"]},{"name":"Department of Public Health Sciences, Medical University of South Carolina , Charleston, SC,","place":["USA"]},{"name":"Hollings Cancer Center, Medical University of South Carolina , Charleston, 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