{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T15:53:50Z","timestamp":1793030030496,"version":"4.5.0"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T00:00:00Z","timestamp":1720656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"NICHD","doi-asserted-by":"publisher","award":["K12 HD043483"],"award-info":[{"award-number":["K12 HD043483"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P50 CA236733"],"award-info":[{"award-number":["P50 CA236733"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Overall, gastric adenocarcinoma (GC) incidence rates have declined in recent years, but racial and ethnic disparities persist. Individuals who identify as Hispanic\/Spanish\/Latino are diagnosed with GC at younger ages and have poorer outcomes than non-Hispanic individuals. However, our understanding of GC biology across racial\/ethnic groups remains limited. We assessed tumor genomic patterns by race\/ethnicity among 1019 patients with primary GC in the American Association for Cancer Research (AACR) Project GENIE Consortium. Hispanic individuals presented with significantly higher rates of ERBB2\/HER2 amplification vs other racial\/ethnic groups (Hispanic: 13.9% vs 9.8% non-Hispanic White, 8.1% non-Hispanic Asian, and 11.0% non-Hispanic Black; P\u2009&amp;lt;\u2009.001, FDR adjusted q\u2009&amp;lt;\u20090.001). Hispanic patients also had higher odds of an ERBB2 amplification vs non-Hispanic Whites in adjusted models (OR\u2009=\u20092.52, 95%CI\u2009=\u20091.20 to 5.33, P\u2009=\u2009.015). These findings underscore the important role of genomic factors in GC disparities. Ensuring equitable access to genomic profiling and targeted therapies, such as trastuzumab for HER2-overexpressing GC, is a promising avenue to mitigate GC disparities and improve outcomes.<\/jats:p>","DOI":"10.1093\/jnci\/djae147","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T01:39:32Z","timestamp":1720748372000},"page":"1830-1833","source":"Crossref","is-referenced-by-count":6,"title":["ERBB2 amplification in gastric cancer: a genomic insight into ethnic disparities"],"prefix":"10.1093","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5144-0577","authenticated-orcid":false,"given":"Muhammad Bilal","family":"Mirza","sequence":"first","affiliation":[{"name":"Division of Surgical Oncology and Endocrine Surgery, Department of Surgery, Vanderbilt University Medical Center , Nashville, TN,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungyoon","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Oncology\/Hematology, Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine , Ansan,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Marincola Smith","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology and Endocrine Surgery, Department of Surgery, Vanderbilt University Medical Center , Nashville, TN,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan J","family":"Baechle","sequence":"additional","affiliation":[{"name":"Department of Bioengineering and Therapeutic Sciences, University of California San Francisco , San Francisco, CA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandrasekhar","family":"Padmanabhan","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology and Endocrine Surgery, Department of Surgery, Vanderbilt University Medical Center , Nashville, TN,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreana N","family":"Holowatyj","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center, Vanderbilt-Ingram Cancer Center , Nashville, TN,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailja C","family":"Shah","sequence":"additional","affiliation":[{"name":"GI Section, VA San Diego Health System , La Jolla, CA,","place":["USA"]},{"name":"Division of Gastroenterology, Department of Medicine, University of California , San Diego, CA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5269-1294","authenticated-orcid":false,"given":"Xingyi","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, Department of Medicine, Vanderbilt Epidemiology Center, and Vanderbilt-Ingram Cancer Center , Nashville, TN,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0911-4461","authenticated-orcid":false,"given":"Kamran","family":"Idrees","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology and Endocrine Surgery, Department of Surgery, Vanderbilt University Medical Center , Nashville, TN,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,11]]},"reference":[{"issue":"11","key":"2024110723565565700_djae147-B1","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1158\/2767-9764.CRC-22-0149","article-title":"Multiregional sequencing analysis reveals extensive genetic heterogeneity in gastric tumors from Latinos","volume":"2","author":"Toal","year":"2022","journal-title":"Cancer Res. Commun"},{"issue":"5","key":"2024110723565565700_djae147-B2","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1053\/j.gastro.2020.07.049","article-title":"Population-based analysis of differences in gastric cancer incidence among races and ethnicities in individuals age 50 years and older","volume":"159","author":"Shah","year":"2020","journal-title":"Gastroenterology"},{"issue":"2","key":"2024110723565565700_djae147-B3","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/s10120-016-0603-7","article-title":"A rising trend in the incidence of advanced gastric cancer in young Hispanic men","volume":"20","author":"Merchant","year":"2017","journal-title":"Gastric Cancer"},{"issue":"11","key":"2024110723565565700_djae147-B4","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1158\/1940-6207.CAPR-19-0200","article-title":"Racial\/ethnic patterns of young-onset noncardia gastric cancer","volume":"12","author":"Holowatyj","year":"2019","journal-title":"Cancer Prev Res (Phila)"},{"issue":"8","key":"2024110723565565700_djae147-B5","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1158\/2159-8290.CD-17-0151","article-title":"AACR Project GENIE: powering precision medicine through an International Consortium","volume":"7","author":"Andr\u00e9","year":"2017","journal-title":"Cancer Discov"},{"issue":"9","key":"2024110723565565700_djae147-B6","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1158\/2159-8290.CD-21-1547","article-title":"AACR Project GENIE: 100,000 cases and beyond","volume":"12","author":"Pugh","year":"2022","journal-title":"Cancer Discov"},{"issue":"5","key":"2024110723565565700_djae147-B7","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1377\/hlthaff.2017.1595","article-title":"Lack of diversity in genomic databases is a barrier to translating precision medicine research into practice","volume":"37","author":"Landry","year":"2018","journal-title":"Health Aff (Millwood)"},{"issue":"7","key":"2024110723565565700_djae147-B8","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1053\/j.gastro.2014.02.005","article-title":"Activation of EGFR and ERBB2 by Helicobacter pylori results in survival of gastric epithelial cells with DNA damage","volume":"146","author":"Chaturvedi","year":"2014","journal-title":"Gastroenterology"},{"issue":"8","key":"2024110723565565700_djae147-B9","first-page":"e43080","article-title":"Unpacking the racial gap: helicobacter pylori infection clearance among different racial groups","volume":"15","author":"Rammohan","year":"2023","journal-title":"Cureus"},{"issue":"9742","key":"2024110723565565700_djae147-B10","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0140-6736(10)61121-X","article-title":"Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial","volume":"376","author":"Bang","year":"2010","journal-title":"Lancet"},{"issue":"7517","key":"2024110723565565700_djae147-B11","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/nature13480","article-title":"Comprehensive molecular characterization of gastric adenocarcinoma","volume":"513","author":"Bass","year":"2014","journal-title":"Nature"}],"container-title":["JNCI: Journal of the National Cancer Institute"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jnci\/advance-article-pdf\/doi\/10.1093\/jnci\/djae147\/59648061\/djae147.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jnci\/article-pdf\/116\/11\/1830\/60482924\/djae147.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jnci\/article-pdf\/116\/11\/1830\/60482924\/djae147.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T23:57:29Z","timestamp":1731023849000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnci\/article\/116\/11\/1830\/7712435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,11]]},"references-count":11,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,7,11]]},"published-print":{"date-parts":[[2024,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jnci\/djae147","relation":{},"ISSN":["0027-8874","1460-2105"],"issn-type":[{"value":"0027-8874","type":"print"},{"value":"1460-2105","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,11]]},"published":{"date-parts":[[2024,7,11]]}}}