{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T03:39:01Z","timestamp":1794368341688,"version":"4.9.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100021981","name":"Hoffmann-La Roche Ltd","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100021981","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The microbiome has been associated with chemotherapy and immune checkpoint inhibitor efficacy. How this pertains to resectable esophageal carcinoma is unknown. Our aim was to identify microbial signatures in resectable esophageal carcinoma associated with response to neoadjuvant chemoradiotherapy with or without an immune checkpoint inhibitor.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>From 2 prospectively collected esophageal carcinoma cohorts (n\u2009=\u2009172 in total) treated with neoadjuvant chemoradiotherapy alone (n\u2009=\u2009132) or a combination of neoadjuvant chemoradiotherapy and an immune checkpoint inhibitor (n\u2009=\u200940), fecal samples were available at baseline, during treatment, and presurgery. Additionally, in the immune checkpoint inhibitor\u2013treated patients, tumor and duodenal snap frozen biopsies were collected over time. Fecal, tumor, and duodenal DNA were extracted for 16S ribosomal RNA sequencing. Associations were investigated between microbiome composition pathological complete response and progression-free survival (PFS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There was a statistically significant shift in the microbiota profile of the fecal, tumor, and duodenal microbiota over time. In the total cohort, patients with a pathological complete response had a stable fecal alpha diversity, while the diversity of poor responders decreased during treatment (P\u2009=\u2009.036). Presurgery, lower alpha diversity (&amp;lt;4.12) was related to worse PFS (log-rank P\u2009=\u2009.025). Baseline tumor biopsies of patients with short PFS had more Fusobacterium. A low baseline duodenal alpha diversity (&amp;lt;3.96) was associated with worse PFS (log-rank P\u2009=\u2009.012).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Lower intestinal alpha diversity was associated with worse response and survival of esophageal carcinoma patients. In tumor biopsies, Fusobacterium was more abundant in patients with poor PFS. After further mechanistic validation, these findings may aid in response prediction and the design of novel microbiome modulating treatments for esophageal carcinoma patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jnci\/djae153","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T23:21:54Z","timestamp":1719357714000},"page":"1834-1844","source":"Crossref","is-referenced-by-count":11,"title":["Fecal, duodenal, and tumor microbiota composition of esophageal carcinoma patients, a longitudinal prospective cohort"],"prefix":"10.1093","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2830-2310","authenticated-orcid":false,"given":"Tom","family":"van den Ende","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Amsterdam University Medical Center, University of Amsterdam , Amsterdam,","place":["the Netherlands"]},{"name":"Cancer Center Amsterdam, Imaging and Biomarkers , Amsterdam,","place":["the 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