{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:27:56Z","timestamp":1790731676813,"version":"4.1.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Mermaid"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Women with a family history of breast and\/or ovarian cancer have an increased ovarian cancer risk. Yet it remains uncertain if common ovarian cancer risk factors\u2014especially those that are modifiable\u2014affect this high-risk population similarly to the general population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Using the Danish and Swedish nationwide registers, we established 2 nested case-control study populations in women with a family history of breast and\/or ovarian cancer (2138 ovarian cancers, 85\u200a240 controls) and women without (10\u200a730 ovarian cancers, 429\u200a200 controls). The overall and histology-specific associations were assessed with conditional logistic regression. The country-specific estimates were combined based on a fixed-effect assumption.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Multiparity, hysterectomy, tubal ligation, salpingectomy, and oral contraceptive (OC) use were associated with a reduced risk of ovarian cancer in women with and without a family history, while endometriosis and menopausal hormone therapy were associated with increased risk. Multiparity and OC use presented protective effects across all histologic subtypes except mucinous ovarian cancer, which was not associated with OC use. Menopausal hormone treatment increased the risk of serous ovarian cancer but decreased the risk of the mucinous and clear cell cancers. Endometriosis was especially related to an increased risk of endometrioid and clear cell ovarian cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Factors associated with a decreased ovarian cancer risk were similar between women with and without a family history of breast and\/or ovarian cancer. Given the higher baseline risk for women with a family history, special attention should be paid to risk factors like endometriosis and nulliparity in this high-risk population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jnci\/djae164","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T05:17:46Z","timestamp":1719983866000},"page":"1767-1774","source":"Crossref","is-referenced-by-count":17,"title":["Ovarian cancer risk factors in relation to family history"],"prefix":"10.1093","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4337-9017","authenticated-orcid":false,"given":"Guoqiao","family":"Zheng","sequence":"first","affiliation":[{"name":"Unit of Virus, Lifestyle and Genes, Danish Cancer Institute , Copenhagen,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5773-5169","authenticated-orcid":false,"given":"Louise","family":"Baandrup","sequence":"additional","affiliation":[{"name":"Unit of Virus, Lifestyle and Genes, Danish Cancer Institute , Copenhagen,","place":["Denmark"]},{"name":"Department of Clinical Medicine, University of Copenhagen , Copenhagen,","place":["Denmark"]},{"name":"D , Roskilde,","place":["Denmark"]},{"name":"epartment of Pathology, Zealand University Hospital , Roskilde,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangrong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Intervention and Technology, Karolinska Institutet , Stockholm,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasmus","family":"Hertzum-Larsen","sequence":"additional","affiliation":[{"name":"Unit of Virus, Lifestyle and Genes, Danish Cancer Institute , Copenhagen,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte Gerd","family":"Hannibal","sequence":"additional","affiliation":[{"name":"Unit of Virus, Lifestyle and Genes, Danish Cancer Institute , Copenhagen,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette Tuxen","family":"Faber","sequence":"additional","affiliation":[{"name":"Unit of Virus, Lifestyle and Genes, Danish Cancer Institute , Copenhagen,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Sundstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Intervention and Technology, Karolinska Institutet , Stockholm,","place":["Sweden"]},{"name":"Clinical Pathology and Cancer Diagnostics, Medical Diagnostics Karolinska, Karolinska University Hospital , Stockholm,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne K","family":"Kj\u00e6r","sequence":"additional","affiliation":[{"name":"Unit of Virus, Lifestyle and Genes, Danish Cancer Institute , Copenhagen,","place":["Denmark"]},{"name":"Department of Clinical Medicine, University of Copenhagen , Copenhagen,","place":["Denmark"]},{"name":"Department of Gynecology, Rigshospitalet, University of Copenhagen , Copenhagen,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,4]]},"reference":[{"issue":"3","key":"2024110723563440100_djae164-B1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J 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