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<jats:title>Background<\/jats:title>\n                  <jats:p>Inflammation and insufficient physical inactivity contribute to individual-level risk of disease recurrence and death in stage III colon cancer. The extent to which increased inflammatory risk can be offset by sufficient physical activity remains unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This cohort study was nested within the Cancer and Leukemia Group B (now part of the Alliance for Clinical Trials in Oncology) and Southwest Oncology Group randomized trial. Inflammatory burden was quantified by high-sensitivity C-reactive protein, interleukin-6, and soluble tumor necrosis factor-\u03b1 receptor 2 after recovery from tumor resection. Physical activity was measured during and after postoperative chemotherapy. The primary endpoint was disease-free survival.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The 3-year disease-free survival rate was 88.4% among patients with low inflammation and sufficient physical activity (referent group for all comparisons), 84.9% with low inflammation and insufficient physical activity (absolute risk difference = \u22123.5 percentage points, 95% confidence interval [CI] = \u221211.3 to 4.3; P\u2009=\u2009.38), 78.0% with intermediate inflammation and insufficient physical activity (absolute risk difference = \u221210.4 percentage points, 95% CI = \u221217.4 to \u22123.3; P\u2009=\u2009.007), and 79.7% with high inflammation and insufficient physical activity (absolute risk difference = \u22128.7 percentage points, 95% CI = \u221215.7 to \u22121.6; P\u2009=\u2009.022). In contrast, the 3-year disease-free survival rate was 87.3% among patients with intermediate inflammation and sufficient physical activity (absolute risk difference = \u22121.1 percentage points, 95% CI = \u22127.5 to 5.3; P\u2009=\u2009.74) and 84.4% with high inflammation and sufficient physical activity (absolute risk difference = \u22124.0 percentage points, 95% CI = \u221212.3 to 4.3; P\u2009=\u2009.34).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In this observational study of stage III colon cancer patients, physical activity was associated with improved disease-free survival despite high inflammation. Patients with intermediate or high inflammation who were physically active had disease-free survival rates that were not statistically significantly different from those with low inflammation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jnci\/djae203","type":"journal-article","created":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T15:53:10Z","timestamp":1724514790000},"page":"2032-2039","source":"Crossref","is-referenced-by-count":4,"title":["Inflammation, physical activity, and disease-free survival in stage III colon cancer: Cancer and Leukemia Group B\u2013Southwest Oncology Group 80702 (Alliance)"],"prefix":"10.1093","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7540-4913","authenticated-orcid":false,"given":"Justin C","family":"Brown","sequence":"first","affiliation":[{"name":"Pennington Biomedical Research Center , Baton Rouge, LA,","place":["USA"]},{"name":"New Orleans School of Medicine, Louisiana State University Health Sciences Center , New Orleans, LA,","place":["USA"]},{"name":"Stanley S. 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