{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:17:16Z","timestamp":1791303436644,"version":"4.1.0"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U10CA180868"],"award-info":[{"award-number":["U10CA180868"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U10CA180822"],"award-info":[{"award-number":["U10CA180822"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["UG1CA189867"],"award-info":[{"award-number":["UG1CA189867"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"NCI","doi-asserted-by":"publisher","award":["U10CA180868"],"award-info":[{"award-number":["U10CA180868"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"NCI","doi-asserted-by":"publisher","award":["U10CA180822"],"award-info":[{"award-number":["U10CA180822"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"NCI","doi-asserted-by":"publisher","award":["UG1CA189867"],"award-info":[{"award-number":["UG1CA189867"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Miami Breast Cancer Conference 2023"},{"name":"Northwell Health Cancer Institute 2022"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>NRG Oncology NSABP B-39\/RTOG 0413 compared whole-breast irradiation (WBI) to accelerated partial-breast irradiation (APBI). APBI was not equivalent to WBI in local tumor control. Secondary outcome was quality of life (QOL).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The QOL sub-study used validated self-report questionnaires, including the Breast Cancer Treatment Outcome Scale (BCTOS) and the 36-Item Short Form Health Survey (SF-36) vitality scale. Assessments occurred before random assignment, at treatment completion (chemotherapy or radiotherapy), 4 weeks later, at 6, 12, 24, and 36 months. Primary aims: cosmesis change equivalency (baseline to 3\u2009years; a priori margin of equivalence 0.4 standard deviations) and fatigue change superiority (baseline to end of treatment [EOT]) for APBI vs WBI, by patient groups treated with or without chemotherapy when appropriate.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>From March 21, 2005 to May 25, 2009, 975 patients enrolled in this sub-study; 950 had follow-up data. APBI had 3-year cosmesis equivalent to WBI (95% CI = -0.0001 to -0.16; equivalence margin -0.22 to -0.22) in all patients. The APBI group without chemotherapy had less EOT fatigue (P\u2009=\u2009.011; mean score APBI 63 vs WBI 59); the APBI group receiving chemotherapy had worse EOT fatigue (P\u2009=\u2009.011; APBI 43 vs WBI 49). The APBI group reported less pain (BCTOS) at EOT (WBI 2.29 vs APBI 1.97) but worse pain at 3 years (WBI 1.62 vs APBI 1.71). APBI patients reported greater convenience of care than with WBI and reported less symptom severity at EOT and 4 weeks later.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Cosmetic outcomes were similar for the APBI and WBI groups, with small statistically significant differences in other outcomes that varied over time. Differences in fatigue and other symptoms appeared to resolve by \u22656\u2009months. APBI may be preferred by some patients, for whom extended treatment is burdensome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>ClinicalTrials.gov<\/jats:title>\n                  <jats:p>NCT00103181.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jnci\/djae219","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T14:30:21Z","timestamp":1725978621000},"page":"103-111","source":"Crossref","is-referenced-by-count":5,"title":["Quality-of-life outcomes from NRG Oncology NSABP B-39\/RTOG 0413: whole-breast irradiation vs accelerated partial-breast irradiation after breast-conserving surgery"],"prefix":"10.1093","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1841-4143","authenticated-orcid":false,"given":"Patricia A","family":"Ganz","sequence":"first","affiliation":[{"name":"Department of Medicine (Hematology\/Oncology), David Geffen School of Medicine at UCLA; Department of Health Policy & Management, UCLA Fielding School of Public Health; UCLA Jonsson Comprehensive Cancer Center , Los Angeles, CA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9075-9357","authenticated-orcid":false,"given":"Reena S","family":"Cecchini","sequence":"additional","affiliation":[{"name":"NRG Oncology Statistics and Data Management Center, and Department of Biostatistics, University of Pittsburgh School of Public Health , Pittsburgh, PA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6624-5631","authenticated-orcid":false,"given":"Julia R","family":"White","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Kansas Medical Center Comprehensive Cancer Center , Kansas City, KS,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank A","family":"Vicini","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Michigan Healthcare Professionals , Pontiac, MI,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas W","family":"Arthur","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Virginia Commonwealth University School of Medicine Massey Comprehensive Cancer Center , Richmond, VA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel A","family":"Rabinovitch","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Colorado Cancer Center, Aurora , CO,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3089-5970","authenticated-orcid":false,"given":"Robert R","family":"Kuske","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Arizona Breast Cancer Specialists , Scottsdale, AZ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas B","family":"Julian","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Allegheny Health Network Cancer Institute , Pittsburgh, PA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S","family":"Parda","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Allegheny General Hospital , Pittsburgh, PA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F","family":"Scheier","sequence":"additional","affiliation":[{"name":"Department of Psychology, Carnegie Mellon University , Pittsburgh, PA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn A","family":"Winter","sequence":"additional","affiliation":[{"name":"NRG Oncology Statistics and Data Management Center, and The American College of Radiology , Philadelphia, PA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9688-6480","authenticated-orcid":false,"given":"Soonmyung","family":"Paik","sequence":"additional","affiliation":[{"name":"Department of Oncology\/Hematology, Theragenbio, Inc, Pangyo, and Severance Biomedical Science Institute at Yonsei University College of Medicine , Seoul,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry M","family":"Kuerer","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, University of Texas MD Anderson Cancer Center , Houston, TX,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A","family":"Vallow","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Mayo Clinic Florida , Jacksonville, FL,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori 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