{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T20:56:37Z","timestamp":1783976197444,"version":"3.55.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004622","name":"Dutch Cancer Society","doi-asserted-by":"crossref","award":["KWF10004"],"award-info":[{"award-number":["KWF10004"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Childhood Cancer Survivor Study"},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA55727"],"award-info":[{"award-number":["CA55727"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Childhood Cancer Survivor Study"},{"name":"St Jude Children\u2019s Research Hospital"},{"name":"Cancer Center Support","award":["CA21765"],"award-info":[{"award-number":["CA21765"]}]},{"DOI":"10.13039\/100012524","name":"American Lebanese-Syrian Associated Charities","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Although female survivors of Hodgkin lymphoma (HL) have an increased risk of breast cancer (BC), no BC risk prediction model is available. We developed such models incorporating mean radiation dose to the breast or breast quadrant-specific radiation doses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Relative risks and age-specific incidence for BC and competing events (mortality or other subsequent cancer) were estimated from 1194 Dutch 5-year HL survivors, treated at ages 11-40 during 1965-2000. Predictors were doses to 10 breast segments or mean breast radiation dose, BC family history, year of and age at HL diagnosis, and ages at menopause and first live birth. Models were independently validated using US Childhood Cancer Survivor Study cohort participants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Predicted absolute BC risks 25\u2009years after HL diagnosis ranged from 1.0% for survivors diagnosed at ages 20-24 with less than 10\u2009Gy mean breast radiation dose and who were menopausal 5\u2009years after HL diagnosis, to 22.0% for survivors 25-29\u2009years at diagnosis, with at least 25\u2009Gy mean breast dose and no menopause within 5\u2009years. In external validation, the observed\/expected BC case ratio was 1.19 (95% confidence interval 0.97 to 1.47) for the breast segment-specific dose model, and 1.29 (1.05 to 1.60) for the mean breast dose model. The areas under the receiver operating characteristic curve were 0.68 (0.63 to 0.74) and 0.68 (0.62 to 0.73), respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Breast segment-specific or mean breast radiation dose with personal and clinical characteristics predicted absolute BC risk in HL survivors with moderate discrimination but good calibration, rendering the models useful for clinical decision-making.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jnci\/djae274","type":"journal-article","created":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T15:54:18Z","timestamp":1730476458000},"page":"619-628","source":"Crossref","is-referenced-by-count":10,"title":["Prediction of breast cancer risk for adolescents and young adults with Hodgkin lymphoma"],"prefix":"10.1093","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6275-7442","authenticated-orcid":false,"given":"Sander","family":"Roberti","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, The Netherlands Cancer Institute , 1066 CX Amsterdam,","place":["the Netherlands"]},{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute , Bethesda, MD 20892,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5871-1484","authenticated-orcid":false,"given":"Flora E","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, The Netherlands Cancer Institute , 1066 CX Amsterdam,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8272-8817","authenticated-orcid":false,"given":"Ibrahima","family":"Diallo","sequence":"additional","affiliation":[{"name":"University Paris Saclay , 94800 Villejuif,","place":["France"]},{"name":"Molecular Radiation Therapy and Therapeutic Innovation, INSERM U1030 , 94805 Villejuif,","place":["France"]},{"name":"Radiation Oncology Department, Gustave Roussy , 94805 Villejuif,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8374-9281","authenticated-orcid":false,"given":"Florent","family":"de Vathaire","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department, Gustave Roussy , 94805 Villejuif,","place":["France"]},{"name":"Radiation Epidemiology Team, Center for Research in Epidemiology and Population Health, INSERM U1018 , 94807 Villejuif,","place":["France"]},{"name":"Research Department, Gustave Roussy , 94805 Villejuif,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4390-7182","authenticated-orcid":false,"given":"Michael","family":"Schaapveld","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, The Netherlands Cancer Institute , 1066 CX Amsterdam,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy M","family":"Leisenring","sequence":"additional","affiliation":[{"name":"Clinical Research Division, Fred Hutchinson Cancer Research Center , Seattle, WA 98109,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca M","family":"Howell","sequence":"additional","affiliation":[{"name":"Department of Radiation Physics, University of Texas M.D. Anderson Cancer Center , Houston, TX 77030,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory T","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control, St Jude Children\u2019s Research Hospital , Memphis, TN 38105,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2850-8450","authenticated-orcid":false,"given":"Chaya S","family":"Moskowitz","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center , New York, NY 10065,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan A","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Radiation Physics, University of Texas M.D. Anderson Cancer Center , Houston, TX 77030,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berthe M 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