{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:07:02Z","timestamp":1788926822773,"version":"build-2803163510"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T00:00:00Z","timestamp":1732233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005010","name":"The Italian Foundation for Cancer Research","doi-asserted-by":"crossref","award":["22987"],"award-info":[{"award-number":["22987"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Italian Ministry of Education and Research"},{"name":"Dept. of Pathophysiology and Transplantation"},{"DOI":"10.13039\/100012352","name":"Universit\u00e0 degli Studi di Milano","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012352","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Rising cancer incidence, particularly for colorectal cancer, has been reported in young adults. This study examined whether this is related to an increase in mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We analyzed World Health Organization mortality data among young adults aged 25-49 years in 15 most populous upper-middle and high-income countries from 1990 to 2021 with reliable data. Midyear populations were retrieved from the United Nations for the American Countries and from the World Health Organization for the other countries. We compared age-standardized mortality rates in 2019-2021 with those in 2009-2011 and performed joinpoint regression analysis for all cancers and selected most common cancer sites: colorectum, pancreas, lung, and breast.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In 2019-2021, the highest age-standardized mortality rates (per 100\u200a000) were in Romanian males (38.6) and Argentinian females (45.9), while the lowest ones were in Japanese males (16.3) and females (22.7). Age-standardized mortality rates for colorectal cancers increased in 2019-2021 compared with 2009-2011 in 9 countries among men and in 7 countries among women. The highest increases were in the United Kingdom (males: +26.1%; females: +33.7%), Canada (males: +25.3%), and Mexico (males: +33.5%; females: +29.7%). Long-term analysis over the last 3 decades showed declining trends in total cancer mortality in the majority of countries, in lung cancer mortality across all countries, and in breast cancer in all countries except in Latin America.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Although mortality from common cancers has generally decreased over the past 3 decades, mortality from colorectal cancer has increased in some countries. This highlights the need to control the obesity epidemic and implement targeted surveillance strategies in young populations.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jnci\/djae288","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T16:51:42Z","timestamp":1732294302000},"page":"747-760","source":"Crossref","is-referenced-by-count":30,"title":["Trends in cancer mortality under age 50 in 15 upper-middle and high-income countries"],"prefix":"10.1093","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9845-5307","authenticated-orcid":false,"given":"Claudia","family":"Santucci","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences and Community Health, Department of Excellence 2023-2027, University of Milan , 20133 Milan,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5703-0534","authenticated-orcid":false,"given":"Silvia","family":"Mignozzi","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health, Department of Excellence 2023-2027, University of Milan , 20133 Milan,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0430-2714","authenticated-orcid":false,"given":"Gianfranco","family":"Alicandro","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation, University of Milan , 20122 Milan,","place":["Italy"]},{"name":"Mother and Child Department, Cystic Fibrosis Centre, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico , 20122 Milan,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0340-0435","authenticated-orcid":false,"given":"Margherita","family":"Pizzato","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health, Department of Excellence 2023-2027, University of Milan , 20133 Milan,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9110-3923","authenticated-orcid":false,"given":"Matteo","family":"Malvezzi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Parma , 43126 Parma,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9712-8526","authenticated-orcid":false,"given":"Eva","family":"Negri","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Bologna , 40138 Bologna,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7067-8341","authenticated-orcid":false,"given":"Prabhat","family":"Jha","sequence":"additional","affiliation":[{"name":"Centre for Global Health Research, Unity Health Toronto, Dalla Lana School of Public Health, University of Toronto , Toronto, ON M5B 1W8,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1441-897X","authenticated-orcid":false,"given":"Carlo","family":"La Vecchia","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health, Department of Excellence 2023-2027, University of Milan , 20133 Milan,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,11,22]]},"reference":[{"key":"2025040623585056300_djae288-B1","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/S1470-2045(24)00274-2","article-title":"Premature mortality trends in 183 countries by cancer type, sex, WHO region, and World Bank income level in 2000-19: a retrospective, cross-sectional, population-based study","volume":"25","author":"Murthy","year":"2024","journal-title":"Lancet Oncol"},{"key":"2025040623585056300_djae288-B2","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/s41571-022-00672-8","article-title":"Is early-onset cancer an emerging global epidemic? 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