{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:14:58Z","timestamp":1792167298376,"version":"4.4.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["75N91019D00024"],"award-info":[{"award-number":["75N91019D00024"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Emerging evidence suggests that bacteria residing in colorectal tissue are plausibly associated with colorectal cancer. Prior studies investigated the effects of dietary interventions on the fecal microbiome, but few assessed colorectal tissue microbiome endpoints. We investigated the effects of a high-fiber, high-fruit, high-vegetable, and low-fat dietary intervention on the rectal tissue microbiome in the Polyp Prevention Trial (PPT).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>PPT is a 4-year randomized clinical trial with intervention goals of consuming (1) at least 18\u2009g of fiber per 1000\u2009kcal\/day; (2) at least 3.5 servings of fruits and vegetables per 1000\u2009kcal\/day; and (3) no more than 20% of kcal\/day from fat. Using 16S ribosomal RNA gene sequencing, we characterized bacteria in rectal biopsies collected at baseline and the end of years 1 and 4 (n\u2009=\u2009233 in intervention arm and n\u2009=\u2009222 in control arm). We estimated effects of the intervention on alpha and beta diversity and relative abundance of a priori\u2013selected bacteria using repeated-measures linear mixed-effects models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The intervention did not statistically significantly modify rectal tissue alpha diversity. Compared with the control arm, relative abundance of a priori\u2013selected Porphyromonas (absolute intervention effects [standard errors] at T1 vs T0\u2009=\u2009\u20130.24 [0.07] and T4 vs T0\u2009=\u2009\u20130.12 [0.07]; P\u2009=\u2009.004) and Prevotella (absolute intervention effects at T1 vs T0\u2009=\u2009\u20130.40 [0.14] and at T4 vs T0\u2009=\u2009\u20130.32 [0.15]; P\u2009=\u2009.01) were more strongly decreased in the intervention arm.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The PPT intervention did not influence rectal tissue microbiome diversity or the relative abundance of most bacteria, except for 2 oral-originating bacteria that were previously associated with colorectal cancer presence.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jnci\/djaf034","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T04:23:52Z","timestamp":1739507032000},"page":"1237-1244","source":"Crossref","is-referenced-by-count":4,"title":["Effects of a high-fiber, high-fruit and high-vegetable, low-fat dietary intervention on the rectal tissue microbiome"],"prefix":"10.1093","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4275-7901","authenticated-orcid":false,"given":"Doratha A","family":"Byrd","sequence":"first","affiliation":[{"name":"Department of Cancer Epidemiology, Moffitt Cancer Center , Tampa, FL 33612,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3041-8259","authenticated-orcid":false,"given":"Maria","family":"Gomez","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology, Moffitt Cancer Center , Tampa, FL 33612,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5677-3518","authenticated-orcid":false,"given":"Stephanie","family":"Hogue","sequence":"additional","affiliation":[{"name":"Non-therapeutic Research Office, Moffitt Cancer Center , Tampa, FL 33612,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6556-0602","authenticated-orcid":false,"given":"Yunhu","family":"Wan","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute , Rockville, MD 20850,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5589-9557","authenticated-orcid":false,"given":"Ana","family":"Ortega-Villa","sequence":"additional","affiliation":[{"name":"Division of Clinical Research, National Institute of Allergy and Infectious Diseases , Rockville, MD 20852,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6023-1423","authenticated-orcid":false,"given":"Andrew","family":"Warner","sequence":"additional","affiliation":[{"name":"Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc , Frederick, MD 21701,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7334-4718","authenticated-orcid":false,"given":"Casey","family":"Dagnall","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute , Rockville, MD 20850,","place":["United States"]},{"name":"Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc , Frederick, MD 21701,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1584-8920","authenticated-orcid":false,"given":"Kristine","family":"Jones","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute , Rockville, MD 20850,","place":["United States"]},{"name":"Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc , Frederick, MD 21701,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8014-4888","authenticated-orcid":false,"given":"Belynda","family":"Hicks","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute , Rockville, MD 20850,","place":["United States"]},{"name":"Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc , Frederick, MD 21701,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1658-1068","authenticated-orcid":false,"given":"Paul","family":"Albert","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute , Rockville, MD 20850,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0118-5337","authenticated-orcid":false,"given":"Gwen","family":"Murphy","sequence":"additional","affiliation":[{"name":"Cancer Screening and Prevention Research Group, Department of Surgery and Cancer, Imperial College London , London SW7 2AZ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Sinha","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute , Rockville, MD 20850,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1355-5593","authenticated-orcid":false,"given":"Emily","family":"Vogtmann","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute , Rockville, MD 20850,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,2,18]]},"reference":[{"key":"2025060819573614100_djaf034-B1","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1136\/gutjnl-2016-313413","article-title":"Long-term use of antibiotics and risk of colorectal adenoma","volume":"67","author":"Cao","year":"2018","journal-title":"Gut"},{"key":"2025060819573614100_djaf034-B2","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1016\/j.ccell.2018.03.004","article-title":"The Intestinal Microbiota in Colorectal Cancer","volume":"33","author":"Tilg","year":"2018","journal-title":"Cancer Cell"},{"key":"2025060819573614100_djaf034-B3","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/s41522-017-0040-3","article-title":"High-resolution bacterial 16S rRNA gene profile meta-analysis and biofilm status reveal common colorectal cancer consortia","volume":"3","author":"Drewes","year":"2017","journal-title":"NPJ Biofilms Microbiomes"},{"key":"2025060819573614100_djaf034-B4","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/s41591-019-0406-6","article-title":"Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer","volume":"25","author":"Wirbel","year":"2019","journal-title":"Nat Med"},{"key":"2025060819573614100_djaf034-B5","volume-title":"Cancer Facts and Figures 2024","year":"2024"},{"key":"2025060819573614100_djaf034-B6","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/nature12820","article-title":"Diet rapidly and reproducibly alters the human gut microbiome","volume":"505","author":"David","year":"2014","journal-title":"Nature"},{"key":"2025060819573614100_djaf034-B7","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.cgh.2018.07.012","article-title":"Environmental factors, gut microbiota, and colorectal cancer prevention","volume":"17","author":"Song","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2025060819573614100_djaf034-B8","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1017\/S0007114514004127","article-title":"Dietary effects on human gut microbiome diversity","volume":"113(Suppl)","author":"Xu","year":"2015","journal-title":"Br J Nutr"},{"key":"2025060819573614100_djaf034-B9","doi-asserted-by":"publisher","first-page":"4137","DOI":"10.1016\/j.cell.2021.06.019","article-title":"Gut-microbiota-targeted diets modulate human immune status","volume":"184","author":"Wastyk","year":"2021","journal-title":"Cell"},{"key":"2025060819573614100_djaf034-B10","doi-asserted-by":"publisher","first-page":"4155","DOI":"10.1038\/s41467-024-48355-5","article-title":"Gut microbiome remodeling and metabolomic profile improves in response to protein pacing with intermittent fasting versus continuous caloric restriction","volume":"15","author":"Mohr","year":"2024","journal-title":"Nat Commun"},{"key":"2025060819573614100_djaf034-B11","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1038\/s41564-024-01736-4","article-title":"Interactions between diet and gut microbiota in cancer","volume":"9","author":"Nakatsu","year":"2024","journal-title":"Nat Microbiol"},{"key":"2025060819573614100_djaf034-B12","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1136\/gutjnl-2015-309595","article-title":"Tumour-associated and non-tumour-associated microbiota in colorectal cancer","volume":"66","author":"Flemer","year":"2017","journal-title":"Gut"},{"key":"2025060819573614100_djaf034-B13","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1126\/science.aay9189","article-title":"The human tumor microbiome is composed of tumor type-specific intracellular bacteria","volume":"368","author":"Nejman","year":"2020","journal-title":"Science"},{"key":"2025060819573614100_djaf034-B14","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15051602","article-title":"Tissue vs. fecal-derived bacterial dysbiosis in precancerous colorectal lesions: a systematic review","volume":"15","author":"Valciukiene","year":"2023","journal-title":"Cancers (Basel)"},{"key":"2025060819573614100_djaf034-B15","doi-asserted-by":"publisher","first-page":"7980","DOI":"10.1038\/srep07980","article-title":"Dysbiosis of fungal microbiota in the intestinal mucosa of patients with colorectal adenomas","volume":"5","author":"Luan","year":"2015","journal-title":"Sci Rep"},{"key":"2025060819573614100_djaf034-B16","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1158\/1055-9965.EPI-18-1295","article-title":"in the colorectum and its association with cancer risk and survival: a systematic review and meta-analysis","volume":"29","author":"Gethings-Behncke","year":"2020","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2025060819573614100_djaf034-B17","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1007\/s10096-014-2081-3","article-title":"associates with stages of colorectal neoplasia development, colorectal cancer and disease outcome","volume":"33","author":"Flanagan","year":"2014","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"2025060819573614100_djaf034-B18","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1136\/gutjnl-2015-310101","article-title":"in colorectal carcinoma tissue and patient prognosis","volume":"65","author":"Mima","year":"2016","journal-title":"Gut"},{"key":"2025060819573614100_djaf034-B19","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1016\/j.annonc.2020.06.003","article-title":"persistence and risk of recurrence after preoperative treatment in locally advanced rectal cancer","volume":"31","author":"Serna","year":"2020","journal-title":"Ann Oncol"},{"key":"2025060819573614100_djaf034-B20","doi-asserted-by":"publisher","first-page":"46158","DOI":"10.18632\/oncotarget.10064","article-title":"Could gut microbiota serve as prognostic biomarker associated with colorectal cancer patients\u2019 survival? A pilot study on relevant mechanism","volume":"7","author":"Wei","year":"2016","journal-title":"Oncotarget"},{"key":"2025060819573614100_djaf034-B21","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1056\/NEJM200004203421601","article-title":"Lack of effect of a low-fat, high-fiber diet on the recurrence of colorectal adenomas. Polyp Prevention Trial Study Group","volume":"342","author":"Schatzkin","year":"2000","journal-title":"N Engl J Med"},{"key":"2025060819573614100_djaf034-B22","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1016\/0895-4356(90)90099-b","article-title":"Validation of a self-administered diet history questionnaire using multiple diet records","volume":"43","author":"Block","year":"1990","journal-title":"J Clin Epidemiol"},{"key":"2025060819573614100_djaf034-B23","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1093\/ajcn\/74.3.387","article-title":"Implementation of a 4-y, high-fiber, high-fruit-and-vegetable, low-fat dietary intervention: Results of dietary changes in the Polyp Prevention Trial","volume":"74","author":"Lanza","year":"2001","journal-title":"Am J Clin Nutr"},{"key":"2025060819573614100_djaf034-B24","doi-asserted-by":"publisher","first-page":"e00533","DOI":"10.14309\/ctg.0000000000000533","article-title":"Circulating bile acids and adenoma recurrence in the context of adherence to a high-fiber, high-fruit and vegetable, and low-fat dietary intervention","volume":"13","author":"Byrd","year":"2022","journal-title":"Clinical and Translational Gastroenterology"},{"key":"2025060819573614100_djaf034-B25","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1093\/aje\/kwp169","article-title":"The effect of strict adherence to a high-fiber, high-fruit and -vegetable, and low-fat eating pattern on adenoma recurrence","volume":"170","author":"Sansbury","year":"2009","journal-title":"Am J Epidemiol"},{"key":"2025060819573614100_djaf034-B26","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1158\/1055-9965.EPI-22-0608","article-title":"Prospective and cross-sectional associations of the rectal tissue microbiome with colorectal adenoma recurrence","volume":"32","author":"Byrd","year":"2023","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2025060819573614100_djaf034-B27","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: High-resolution sample inference from Illumina amplicon data","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat Methods"},{"key":"2025060819573614100_djaf034-B28","author":"Oksanen"},{"key":"2025060819573614100_djaf034-B29","doi-asserted-by":"publisher","first-page":"101828","DOI":"10.1016\/j.bpg.2023.101828","article-title":"The role of diet in shaping human gut microbiota","volume":"62-63","author":"Rinninella","year":"2023","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"2025060819573614100_djaf034-B30","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1093\/ajcn\/nqaa046","article-title":"Long-term dietary intervention reveals resilience of the gut microbiota despite changes in diet and weight","volume":"111","author":"Fragiadakis","year":"2020","journal-title":"Am J Clin Nutr"},{"key":"2025060819573614100_djaf034-B31","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10122507","article-title":"Dietary fiber intake and gut microbiota in human health","volume":"10","author":"Fu","year":"2022","journal-title":"Microorganisms"},{"key":"2025060819573614100_djaf034-B32","doi-asserted-by":"publisher","DOI":"10.1128\/mSystems.00115-21","article-title":"High-fiber, whole-food dietary intervention alters the human gut microbiome but not fecal short-chain fatty acids","volume":"6","author":"Oliver","year":"2021","journal-title":"mSystems"},{"key":"2025060819573614100_djaf034-B33","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/s13073-021-00921-y","article-title":"Dietary fiber intake, the gut microbiome, and chronic systemic inflammation in a cohort of adult men","volume":"13","author":"Ma","year":"2021","journal-title":"Genome Med"},{"key":"2025060819573614100_djaf034-B34","doi-asserted-by":"publisher","first-page":"9588","DOI":"10.3390\/ijms23179588","article-title":"Influence of foods and nutrition on the gut microbiome and implications for intestinal health","volume":"23","author":"Zhang","year":"2022","journal-title":"IJMS"},{"key":"2025060819573614100_djaf034-B35","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1126\/science.1208344","article-title":"Linking long-term dietary patterns with gut microbial enterotypes","volume":"334","author":"Wu","year":"2011","journal-title":"Science"},{"key":"2025060819573614100_djaf034-B36","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1053\/j.gastro.2019.06.048","article-title":"Influence of the gut microbiome, diet, and environment on risk of colorectal cancer","volume":"158","author":"Song","year":"2020","journal-title":"Gastroenterology"},{"key":"2025060819573614100_djaf034-B37","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/nature12506","article-title":"Richness of human gut microbiome correlates with metabolic markers","volume":"500","author":"Le Chatelier","year":"2013","journal-title":"Nature"},{"key":"2025060819573614100_djaf034-B38","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/nrgastro.2017.88","article-title":"Gut microbiota and IBD: Causation or correlation?","volume":"14","author":"Ni","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2025060819573614100_djaf034-B39","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1016\/j.cell.2016.10.043","article-title":"A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility","volume":"167","author":"Desai","year":"2016","journal-title":"Cell"},{"key":"2025060819573614100_djaf034-B40","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/s41591-019-0406-6","article-title":"Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer","volume":"25","author":"Wirbel","year":"2019","journal-title":"Nat Med"},{"key":"2025060819573614100_djaf034-B41","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1158\/1940-6207.CAPR-17-0370","article-title":"Spatial variation of the native colon microbiota in healthy adults","volume":"11","author":"Flynn","year":"2018","journal-title":"Cancer Prev Res (Phila)"},{"key":"2025060819573614100_djaf034-B42","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1126\/science.1110591","article-title":"Diversity of the human intestinal microbial flora","volume":"308","author":"Eckburg","year":"2005","journal-title":"Science"},{"key":"2025060819573614100_djaf034-B43","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1038\/ismej.2013.185","article-title":"Spatial heterogeneity and co-occurrence patterns of human mucosal-associated intestinal microbiota","volume":"8","author":"Zhang","year":"2014","journal-title":"ISME J"},{"key":"2025060819573614100_djaf034-B44","doi-asserted-by":"publisher","first-page":"18321","DOI":"10.1073\/pnas.1406199111","article-title":"Microbiota organization is a distinct feature of proximal colorectal cancers","volume":"111","author":"Dejea","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025060819573614100_djaf034-B45","doi-asserted-by":"publisher","first-page":"e200","DOI":"10.1038\/ctg.2016.53","article-title":"in colorectal carcinoma tissue according to tumor location","volume":"7","author":"Mima","year":"2016","journal-title":"Clin Transl Gastroenterol"}],"container-title":["JNCI: Journal of the National Cancer Institute"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jnci\/advance-article-pdf\/doi\/10.1093\/jnci\/djaf034\/62040514\/djaf034.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jnci\/article-pdf\/117\/6\/1237\/62040514\/djaf034.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jnci\/article-pdf\/117\/6\/1237\/62040514\/djaf034.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T23:57:43Z","timestamp":1749427063000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnci\/article\/117\/6\/1237\/8029133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,18]]},"references-count":45,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,2,18]]},"published-print":{"date-parts":[[2025,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jnci\/djaf034","relation":{},"ISSN":["0027-8874","1460-2105"],"issn-type":[{"value":"0027-8874","type":"print"},{"value":"1460-2105","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,6]]},"published":{"date-parts":[[2025,2,18]]}}}