{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:06:20Z","timestamp":1790384780215,"version":"4.1.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"The Netherlands Organization for Health Research and Development","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001826","name":"ZonMW","doi-asserted-by":"publisher","award":["848101007"],"award-info":[{"award-number":["848101007"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The association of body composition with checkpoint inhibitor outcomes in melanoma is a matter of ongoing debate. In this study, we aim to investigate body mass index (BMI) alongside computed tomography (CT)-derived body composition metrics in the largest cohort to date.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients treated with first-line anti-PD1\u2009\u00b1\u2009anti-CTLA4 for advanced melanoma were retrospectively identified from 11 melanoma centers in The Netherlands. From baseline CT scans, 5 body composition metrics were extracted: subcutaneous adipose tissue index, visceral adipose tissue index, skeletal muscle index, density, and gauge. These metrics were correlated in univariable and multivariable Cox proportional hazards analysis with progression-free survival, overall survival, and melanoma-specific survival (PFS, OS, and MSS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 1471 eligible patients were included. Median PFS and OS were 9.1 and 38.1\u2009months, respectively. Worse PFS was observed in underweight patients (multivariable hazard ratio [HR]\u2009=\u20091.86, 95% CI\u2009=\u20091.14 to 3.06). Furthermore, prolonged OS was observed in patients with higher skeletal muscle density (multivariable HR\u2009=\u20090.88, 95% CI\u2009=\u20090.81 to 0.97) and gauge (multivariable HR\u2009=\u20090.61, 95% CI\u2009=\u20090.82 to 0.998), whereas higher visceral adipose tissue index was associated with worse OS (multivariable HR\u2009=\u20091.12, 95% CI\u2009=\u20091.04 to 1.22). No association with survival outcomes was found for overweight, obesity, or subcutaneous adipose tissue.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our findings suggest that underweight BMI is associated with worse PFS, whereas higher skeletal muscle density and lower visceral adipose tissue index were associated with improved OS. These associations were independent of known prognostic factors, including sex, age, performance status, and extent of disease. No significant association between higher BMI and survival outcomes was observed.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jnci\/djaf039","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T12:50:30Z","timestamp":1739364630000},"page":"1245-1252","source":"Crossref","is-referenced-by-count":12,"title":["Body composition and checkpoint inhibitor treatment outcomes in advanced melanoma: a multicenter cohort study"],"prefix":"10.1093","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2631-7271","authenticated-orcid":false,"given":"Mark","family":"Schuiveling","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, University Medical Center Utrecht, Utrecht University , Utrecht,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4879-9187","authenticated-orcid":false,"given":"Laurens S","family":"Ter Maat","sequence":"additional","affiliation":[{"name":"Image Sciences Institute, University Medical Center Utrecht, Utrecht University , Utrecht,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella A J","family":"Van Duin","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, University Medical Center Utrecht, Utrecht University , Utrecht,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rik J","family":"Verheijden","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, University Medical Center Utrecht, Utrecht University , Utrecht,","place":["The Netherlands"]},{"name":"Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University , Utrecht,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max F","family":"Troenokarso","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, University Medical Center Utrecht, Utrecht University , Utrecht,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pim","family":"Moeskops","sequence":"additional","affiliation":[{"name":"Quantib (currently DeepHealth) , Rotterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost J C","family":"Verhoeff","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, University Medical Center Utrecht, Utrecht University , Utrecht,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sjoerd G","family":"Elias","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University , Utrecht,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter A C","family":"van Amsterdam","sequence":"additional","affiliation":[{"name":"Department of Data Science and Biostatistics, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University , Utrecht,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Femke","family":"Burgers","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Netherlands Cancer Institute , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franchette W P J","family":"Van den Berkmortel","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Zuyderland Medical Center , Sittard-Geleen,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marye J","family":"Boers-Sonderen","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Radboudumc, Radboud University , Nijmegen,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn F","family":"Boomsma","sequence":"additional","affiliation":[{"name":"Department of Radiology, Isala Zwolle , Zwolle,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Willem","family":"De Groot","sequence":"additional","affiliation":[{"name":"Isala Oncology Center, Isala Zwolle , Zwolle,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5884-7704","authenticated-orcid":false,"given":"John B A G","family":"Haanen","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Netherlands Cancer Institute , Amsterdam,","place":["The Netherlands"]},{"name":"Department of Medical Oncology, Leiden University Medical Center, Leiden University , Leiden,","place":["The Netherlands"]},{"name":"Melanoma Clinic, Centre Hospitalier Universitaire Vaudois , Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geke A P","family":"Hospers","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, UMC Groningen, University of Groningen , Groningen,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djura","family":"Piersma","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Medisch Spectrum Twente , Enschede,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Vreugdenhil","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Maxima Medical Center , Veldhoven,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans M","family":"Westgeest","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Amphia Hospital , Breda,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Kapiteijn","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Leiden University Medical Center, Leiden University , Leiden,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariette","family":"Labots","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9798-6843","authenticated-orcid":false,"given":"Wouter B","family":"Veldhuis","sequence":"additional","affiliation":[{"name":"Quantib (currently DeepHealth) , Rotterdam,","place":["The Netherlands"]},{"name":"Department of Radiology, University Medical Center Utrecht, Utrecht University , Utrecht,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0658-2745","authenticated-orcid":false,"given":"Paul J","family":"Van Diest","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Medical Center Utrecht, Utrecht University , Utrecht,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pim A","family":"De Jong","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Medical Center Utrecht, Utrecht University , Utrecht,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josien P W","family":"Pluim","sequence":"additional","affiliation":[{"name":"Image Sciences Institute, University Medical Center Utrecht, Utrecht University , Utrecht,","place":["The Netherlands"]},{"name":"Medical Image Analysis, Department of Biomedical Engineering, Eindhoven University of Technology , Eindhoven,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1885-5499","authenticated-orcid":false,"given":"Tim","family":"Leiner","sequence":"additional","affiliation":[{"name":"Quantib (currently DeepHealth) , Rotterdam,","place":["The Netherlands"]},{"name":"Department of Radiology, Mayo Clinical , Rochester, MN,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1711-3098","authenticated-orcid":false,"given":"Mitko","family":"Veta","sequence":"additional","affiliation":[{"name":"Medical Image Analysis, Department of Biomedical Engineering, Eindhoven University of Technology , Eindhoven,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karijn P M","family":"Suijkerbuijk","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, University Medical Center Utrecht, Utrecht University , Utrecht,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,2,20]]},"reference":[{"key":"2025060819573853400_djaf039-B1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1200\/JCO.2007.12.7837","article-title":"Meta-analysis of phase II cooperative group trials in metastatic stage IV melanoma to determine progression-free and overall survival benchmarks for future phase II trials","volume":"26","author":"Korn","year":"2008","journal-title":"J Clin Oncol"},{"key":"2025060819573853400_djaf039-B2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1200\/JCO.21.02229","article-title":"Long-term outcomes with nivolumab plus ipilimumab or nivolumab alone versus ipilimumab in patients with advanced melanoma","volume":"40","author":"Wolchok","year":"2022","journal-title":"J Clin Oncol"},{"key":"2025060819573853400_djaf039-B3","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/S0140-6736(21)01206-X","article-title":"Immune checkpoint inhibitors in melanoma","volume":"398","author":"Carlino","year":"2021","journal-title":"Lancet"},{"key":"2025060819573853400_djaf039-B4","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1126\/science.aaf2834","article-title":"The \u201ccancer immunogram\u201d","volume":"352","author":"Blank","year":"2016","journal-title":"Science"},{"key":"2025060819573853400_djaf039-B5","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/s12967-020-02404-x","article-title":"Association between body mass index and survival outcomes for cancer patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis","volume":"18","author":"An","year":"2020","journal-title":"J Transl Med"},{"key":"2025060819573853400_djaf039-B6","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1007\/s00262-020-02680-y","article-title":"Pretreatment body mass index and clinical outcomes in cancer patients following immune checkpoint inhibitors: a systematic review and meta-analysis","volume":"69","author":"Chen","year":"2020","journal-title":"Cancer Immunol Immunother"},{"key":"2025060819573853400_djaf039-B7","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/CJI.0000000000000389","article-title":"Association between body mass index and survival outcomes in patients treated with immune checkpoint inhibitors: meta-analyses of individual patient data","volume":"44","author":"Nie","year":"2021","journal-title":"J Immunother"},{"key":"2025060819573853400_djaf039-B8","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.semcancer.2023.02.010","article-title":"Obesity and immune-checkpoint inhibitors in advanced melanoma: a meta-analysis of survival outcomes from clinical studies","volume":"91","author":"Roccuzzo","year":"2023","journal-title":"Semin Cancer Biol"},{"key":"2025060819573853400_djaf039-B9","doi-asserted-by":"crossref","first-page":"e000821","DOI":"10.1136\/jitc-2020-000821","article-title":"Impact of body composition on outcomes from anti-PD1 +\/\u2212 anti-CTLA-4 treatment in melanoma","volume":"8","author":"Young","year":"2020","journal-title":"J Immunother Cancer"},{"key":"2025060819573853400_djaf039-B10","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1148\/radiol.2018181432","article-title":"Automated abdominal segmentation of CT scans for body composition analysis using deep learning","volume":"290","author":"Weston","year":"2019","journal-title":"Radiology"},{"key":"2025060819573853400_djaf039-B11","doi-asserted-by":"crossref","first-page":"109943","DOI":"10.1016\/j.ejrad.2021.109943","article-title":"Methodology, clinical applications, and future directions of body composition analysis using computed tomography (CT) images: a review","volume":"145","author":"Tolonen","year":"2021","journal-title":"Eur J Radiol"},{"key":"2025060819573853400_djaf039-B12","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ejca.2022.07.034","article-title":"Imaging to predict checkpoint inhibitor outcomes in cancer. a systematic review","volume":"175","author":"Ter Maat","year":"2022","journal-title":"Eur J Cancer"},{"key":"2025060819573853400_djaf039-B13","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1097\/CJI.0000000000000334","article-title":"Real-world outcomes of first-line anti-PD-1 therapy for advanced melanoma: a nationwide population-based study","volume":"43","author":"van Zeijl","year":"2020","journal-title":"J Immunother"},{"key":"2025060819573853400_djaf039-B14","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1200\/JCO.21.01701","article-title":"Clinical models to define response and survival with anti\u2013PD-1 antibodies alone or combined with ipilimumab in metastatic melanoma","volume":"40","author":"Pires da Silva","year":"2022","journal-title":"J Clin Oncol"},{"key":"2025060819573853400_djaf039-B15","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ejca.2020.11.028","article-title":"Survival outcomes of patients with advanced melanoma from 2013 to 2017: results of a nationwide population-based registry","volume":"144","author":"van Zeijl","year":"2021","journal-title":"Eur J Cancer"},{"key":"2025060819573853400_djaf039-B16","author":"Moeskops"},{"key":"2025060819573853400_djaf039-B17","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3390\/jpm11030159","article-title":"Towards personalised contrast injection: artificial-intelligence-derived body composition and liver enhancement in computed tomography","volume":"11","author":"de Jong","year":"2021","journal-title":"J Pers Med"},{"key":"2025060819573853400_djaf039-B18","doi-asserted-by":"crossref","first-page":"781860","DOI":"10.3389\/fnut.2022.781860","article-title":"Evaluation of a fully automatic deep learning-based method for the measurement of psoas muscle area","volume":"9","author":"Van Erck","year":"2022","journal-title":"Front Nutr"},{"key":"2025060819573853400_djaf039-B19","doi-asserted-by":"crossref","first-page":"968","DOI":"10.3390\/diagnostics13050968","article-title":"Role of machine learning-based CT body composition in risk prediction and prognostication: current state and future directions","volume":"13","author":"Elhakim","year":"2023","journal-title":"Diagnostics (Basel)"},{"key":"2025060819573853400_djaf039-B20","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1158\/1078-0432.CCR-16-0940","article-title":"Skeletal muscle measures as predictors of toxicity, hospitalization, and survival in patients with metastatic breast cancer receiving taxane-based chemotherapy","volume":"23","author":"Shachar","year":"2017","journal-title":"Clin Cancer Res"},{"key":"2025060819573853400_djaf039-B21","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/bjc.2017.149","article-title":"Subcutaneous adiposity is an independent predictor of mortality in cancer patients","volume":"117","author":"Ebadi","year":"2017","journal-title":"Br J Cancer"},{"key":"2025060819573853400_djaf039-B22","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1200\/JCO.2012.45.2722","article-title":"Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index","volume":"31","author":"Martin","year":"2013","journal-title":"J Clin Oncol"},{"key":"2025060819573853400_djaf039-B23","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.2337\/db06-1656","article-title":"Visceral fat adipokine secretion is associated with systemic inflammation in obese humans","volume":"56","author":"Fontana","year":"2007","journal-title":"Diabetes"},{"key":"2025060819573853400_djaf039-B24","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.21873\/anticanres.14528","article-title":"Higher BMI, but not sarcopenia, is associated with pembrolizumab-related toxicity in patients with advanced melanoma","volume":"40","author":"Hu","year":"2020","journal-title":"Anticancer Res"},{"key":"2025060819573853400_djaf039-B25","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.clnesp.2021.01.009","article-title":"Myosteatosis is prognostic in metastatic melanoma treated with nivolumab","volume":"42","author":"Youn","year":"2021","journal-title":"Clin Nutr ESPEN"},{"key":"2025060819573853400_djaf039-B26","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.ctrv.2013.11.007","article-title":"Towards a simple objective framework for the investigation and treatment of cancer cachexia: the Glasgow Prognostic Score","volume":"40","author":"Douglas","year":"2014","journal-title":"Cancer Treat Rev"},{"key":"2025060819573853400_djaf039-B27","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1002\/psp4.12476","article-title":"Population pharmacokinetics of nivolumab in combination with ipilimumab in patients with advanced malignancies","volume":"8","author":"Zhang","year":"2019","journal-title":"CPT Pharmacomet Syst Pharmacol"},{"key":"2025060819573853400_djaf039-B28","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1002\/jcph.962","article-title":"Exposure\u2013response analysis of nivolumab in patients with previously treated or untreated advanced melanoma","volume":"57","author":"Bajaj","year":"2017","journal-title":"J Clin Pharmacol"},{"key":"2025060819573853400_djaf039-B29","doi-asserted-by":"crossref","first-page":"11244","DOI":"10.1038\/s41598-024-61150-y","article-title":"Multi-omic analysis identifies hypoalbuminemia as independent biomarker of poor outcome upon PD-1 blockade in metastatic melanoma","volume":"14","author":"Leek","year":"2024","journal-title":"Sci Rep"},{"key":"2025060819573853400_djaf039-B30","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/jnci\/djad245","article-title":"Physical activity and checkpoint inhibition: association with toxicity and survival","volume":"116","author":"Verheijden","year":"2024","journal-title":"JNCI J Natl Cancer Inst"},{"key":"2025060819573853400_djaf039-B31","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1016\/j.cell.2020.11.009","article-title":"Obesity shapes metabolism in the tumor microenvironment to suppress anti-tumor immunity","volume":"183","author":"Ringel","year":"2020","journal-title":"Cell"},{"key":"2025060819573853400_djaf039-B32","doi-asserted-by":"crossref","first-page":"668494","DOI":"10.3389\/fimmu.2021.668494","article-title":"Re-evaluating the effects of obesity on cancer immunotherapy outcomes in renal cancer: what do we really know?","volume":"12","author":"Farag","year":"2021","journal-title":"Front Immunol"},{"key":"2025060819573853400_djaf039-B33","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1001\/jamaoncol.2022.7753","article-title":"Association of a Mediterranean diet with outcomes for patients treated with immune checkpoint blockade for advanced melanoma","volume":"9","author":"Bolte","year":"2023","journal-title":"JAMA Oncol"},{"key":"2025060819573853400_djaf039-B34","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1634\/theoncologist.2017-0167","article-title":"Fixed dosing of monoclonal antibodies in oncology","volume":"22","author":"Hendrikx","year":"2017","journal-title":"Oncologist"},{"key":"2025060819573853400_djaf039-B35","doi-asserted-by":"crossref","first-page":"1261202","DOI":"10.3389\/fimmu.2023.1261202","article-title":"Prognostic value of body composition on survival outcomes in melanoma patients receiving immunotherapy","volume":"14","author":"Kuang","year":"2023","journal-title":"Front Immunol"}],"container-title":["JNCI: Journal of the National Cancer Institute"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jnci\/advance-article-pdf\/doi\/10.1093\/jnci\/djaf039\/62040874\/djaf039.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jnci\/article-pdf\/117\/6\/1245\/62040874\/djaf039.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jnci\/article-pdf\/117\/6\/1245\/62040874\/djaf039.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T23:57:50Z","timestamp":1749427070000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnci\/article\/117\/6\/1245\/8029201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,20]]},"references-count":35,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,2,20]]},"published-print":{"date-parts":[[2025,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jnci\/djaf039","relation":{},"ISSN":["0027-8874","1460-2105"],"issn-type":[{"value":"0027-8874","type":"print"},{"value":"1460-2105","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,6]]},"published":{"date-parts":[[2025,2,20]]}}}