{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:25:45Z","timestamp":1787009145941,"version":"build-2736575974"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI19\/01195"],"award-info":[{"award-number":["PI19\/01195"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI23\/01047"],"award-info":[{"award-number":["PI23\/01047"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI23\/00017"],"award-info":[{"award-number":["PI23\/00017"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI19\/00553"],"award-info":[{"award-number":["PI19\/00553"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001006","name":"Breast Cancer Research Foundation","doi-asserted-by":"publisher","award":["BCRF-23-203"],"award-info":[{"award-number":["BCRF-23-203"]}],"id":[{"id":"10.13039\/100001006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Secretariat for Universities and Research of the Department of Business and Knowledge","award":["2021SGR01112"],"award-info":[{"award-number":["2021SGR01112"]}]},{"name":"State Agency for Research"},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Center of Excellence Severo Ochoa","award":["CEX2020-001024-S\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["CEX2020-001024-S\/AEI\/10.13039\/501100011033"]}]},{"DOI":"10.13039\/100008050","name":"Cellex Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["PPRPGM-Nov20\\100002"],"award-info":[{"award-number":["PPRPGM-Nov20\\100002"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000023","name":"Government of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000023","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008762","name":"Genome Canada","doi-asserted-by":"publisher","award":["#13529"],"award-info":[{"award-number":["#13529"]}],"id":[{"id":"10.13039\/100008762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["#155865"],"award-info":[{"award-number":["#155865"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Estimating breast cancer risk involves quantifying genetic and non-genetic factors. This supports health interventions and risk communication to ensure adherence to screening recommendations. This study evaluated the change in risk estimation when incorporating breast density and polygenic risk score (PRS) into the baseline cancer risk assessment and compared the efficacy of 2 risk-assessment delivery models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This 2-step study included 663 healthy women with a family history of breast cancer in which no pathogenic variants were identified. First, breast density and PRS were added to the baseline risk assessment for all participants. A randomized intervention study compared 2 delivery models (in-person vs pre-recorded video) for risk assessment in women at moderate or average risk. All tests were 2-sided.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Breast density and PRS reclassified the risk group into 33% of the participants, with only 5% reclassified as high-risk. After disclosure of their estimated multifactorial risk, 65% of women aligned their risk perception with their estimated risk, compared to 47% at baseline (P\u2009&amp;lt;\u2009.05). No statistically significant differences were found in the primary endpoint cancer worry, mean\u2009=\u200910.2 (SD\u2009=\u20093.1) vs 10.1 (2.7), between delivery models. In-person delivery had slightly better psychological outcomes (excluding the primary outcome) and higher satisfaction, though few participants in the video group sought in-person clarification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Incorporating breast density and PRS into risk assessments led to substantial reclassification, with 1 in 5 women facing de-escalated surveillance. Personalized assessments improve objective perceptions alignment. A model using a pre-recorded video-based model matches in-person delivery for moderate and average-risk women and is scalable for population-level implementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jnci\/djaf067","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:51Z","timestamp":1743552051000},"page":"1593-1604","source":"Crossref","is-referenced-by-count":5,"title":["A randomized study of 2 risk assessment models for individualized breast cancer risk estimation"],"prefix":"10.1093","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2844-5998","authenticated-orcid":false,"given":"Adri\u00e0","family":"L\u00f3pez-Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Vall d\u2019Hebron Institute of Oncology (VHIO), Vall d\u2019Hebron Barcelona Hospital Campus , Barcelona,","place":["Spain"]},{"name":"Medical Oncology Department, Vall d\u2019Hebron Barcelona Hospital Campus , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Duran-Lozano","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebron Institute of Oncology (VHIO), Vall d\u2019Hebron Barcelona Hospital Campus , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4868-6585","authenticated-orcid":false,"given":"Guillermo","family":"Villacampa","sequence":"additional","affiliation":[{"name":"Oncology Data Science (ODysSey) Group, VHIO , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Pardo","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebron Institute of Oncology (VHIO), Vall d\u2019Hebron Barcelona Hospital Campus , Barcelona,","place":["Spain"]},{"name":"Genetic Counseling Unit, Oncology Service, Hospital del Mar , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5728-2844","authenticated-orcid":false,"given":"Eduard","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebron Institute of Oncology (VHIO), Vall d\u2019Hebron Barcelona Hospital Campus , Barcelona,","place":["Spain"]},{"name":"Medical Oncology Department, Vall d\u2019Hebron Barcelona Hospital Campus , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7764-1397","authenticated-orcid":false,"given":"Esther","family":"Darder","sequence":"additional","affiliation":[{"name":"Hereditary Cancer Program, Catalan Institute of Oncology, Josep Trueta University Hospital, IDIBGI , Girona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2816-5060","authenticated-orcid":false,"given":"Anna","family":"Vallmaj\u00f3","sequence":"additional","affiliation":[{"name":"Genetic Counseling Unit, Arnau de Vilanova University Hospital , Lleida,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Alfonso","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital de la Santa Creu i Sant Pau , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6953-9675","authenticated-orcid":false,"given":"Mara","family":"Cruellas","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebron Institute of Oncology (VHIO), Vall d\u2019Hebron Barcelona Hospital Campus , Barcelona,","place":["Spain"]},{"name":"Medical Oncology Department, Vall d\u2019Hebron Barcelona Hospital Campus , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0492-7463","authenticated-orcid":false,"given":"Ariadna","family":"Roqu\u00e9","sequence":"additional","affiliation":[{"name":"Hereditary Cancer Program, Catalan Institute of Oncology, Josep Trueta University Hospital, IDIBGI , Girona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3055-4853","authenticated-orcid":false,"given":"Mireia","family":"Cartr\u00f3","sequence":"additional","affiliation":[{"name":"Hereditary Cancer Unit, Corporaci\u00f3 Sanitaria Parc Taul\u00ed , Sabadell,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Bareas","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebron Institute of Oncology (VHIO), Vall d\u2019Hebron Barcelona Hospital Campus , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1964-7675","authenticated-orcid":false,"given":"Estela","family":"Carrasco","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebron Institute of Oncology (VHIO), Vall d\u2019Hebron Barcelona Hospital Campus , Barcelona,","place":["Spain"]},{"name":"Medical Oncology Department, Vall d\u2019Hebron Barcelona Hospital Campus , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9758-9402","authenticated-orcid":false,"given":"Alejandra","family":"Rezqallah","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebron Institute of Oncology (VHIO), Vall d\u2019Hebron Barcelona Hospital Campus , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2796-8569","authenticated-orcid":false,"given":"Ana Raquel","family":"Jimenez-Macedo","sequence":"additional","affiliation":[{"name":"Medical Oncology Service, Consorci Sanitari de Terrassa , Terrassa,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7540-7284","authenticated-orcid":false,"given":"Sara","family":"Torres-Esquius","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebron Institute of Oncology (VHIO), Vall d\u2019Hebron Barcelona Hospital Campus , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maite","family":"Torres","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Vall d\u2019Hebron Barcelona Hospital Campus , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Consol","family":"Lopez","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital de la Santa Creu i Sant Pau , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4293-3875","authenticated-orcid":false,"given":"Mart\u00edn","family":"Espinosa","sequence":"additional","affiliation":[{"name":"Breast Surgical Unit, Vall d\u2019Hebron Barcelona Hospital Campus , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0028-7200","authenticated-orcid":false,"given":"Alex","family":"Teul\u00e9","sequence":"additional","affiliation":[{"name":"Hereditary Cancer Program, Catalan Institute of Oncology\u2014ICO, ONCOBELL\u2014IDIBELL, L\u2019Hospitalet de Llobregat ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), Instituto de Salud Carlos III , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8396-8284","authenticated-orcid":false,"given":"Elisabet","family":"Munt\u00e9","sequence":"additional","affiliation":[{"name":"Hereditary Cancer Program, Catalan Institute of Oncology\u2014ICO, ONCOBELL\u2014IDIBELL, L\u2019Hospitalet de Llobregat ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8432-7059","authenticated-orcid":false,"given":"Noemi","family":"Tuset","sequence":"additional","affiliation":[{"name":"Genetic Counseling Unit, Arnau de Vilanova University Hospital , Lleida,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orland","family":"Diez","sequence":"additional","affiliation":[{"name":"Area of Clinical and Molecular Genetics, Vall d\u2019Hebron Barcelona Hospital Campus , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1736-0112","authenticated-orcid":false,"given":"Lidia","family":"Feliubadal\u00f3","sequence":"additional","affiliation":[{"name":"Hereditary Cancer Program, Catalan Institute of Oncology\u2014ICO, ONCOBELL\u2014IDIBELL, L\u2019Hospitalet de Llobregat ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), Instituto de Salud Carlos III , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7198-5906","authenticated-orcid":false,"given":"Conxi","family":"L\u00e1zaro","sequence":"additional","affiliation":[{"name":"Hereditary Cancer Program, Catalan Institute of Oncology\u2014ICO, ONCOBELL\u2014IDIBELL, L\u2019Hospitalet de Llobregat ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), Instituto de Salud Carlos III , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Llort","sequence":"additional","affiliation":[{"name":"Hereditary Cancer Unit, Corporaci\u00f3 Sanitaria Parc Taul\u00ed , Sabadell,","place":["Spain"]},{"name":"Medical Oncology Service, Consorci Sanitari de Terrassa , Terrassa,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1508-3091","authenticated-orcid":false,"given":"Tim","family":"Carver","sequence":"additional","affiliation":[{"name":"Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge , Cambridge,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0577-1571","authenticated-orcid":false,"given":"Lorenzo","family":"Ficorella","sequence":"additional","affiliation":[{"name":"Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge , Cambridge,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0307-055X","authenticated-orcid":false,"given":"Nasim","family":"Mavaddat","sequence":"additional","affiliation":[{"name":"Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge , Cambridge,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4714-3565","authenticated-orcid":false,"given":"Anna","family":"Mercad\u00e9","sequence":"additional","affiliation":[{"name":"Servei Veterinari de Gen\u00e8tica Molecular (SVGM), Universitat Auton\u00f2ma de Barcelona , Cerdanyola del Vall\u00e8s,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9223-3116","authenticated-orcid":false,"given":"Antonis C","family":"Antoniou","sequence":"additional","affiliation":[{"name":"Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge , Cambridge,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1945-3512","authenticated-orcid":false,"given":"Joan","family":"Brunet","sequence":"additional","affiliation":[{"name":"Hereditary Cancer Program, Catalan Institute of Oncology, Josep Trueta University Hospital, IDIBGI , Girona,","place":["Spain"]},{"name":"Hereditary Cancer Program, Catalan Institute of Oncology\u2014ICO, ONCOBELL\u2014IDIBELL, L\u2019Hospitalet de Llobregat ,","place":["Spain"]},{"name":"Medical Sciences Department School of Medicine, University of Girona , Girona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3490-3585","authenticated-orcid":false,"given":"Teresa","family":"Ramon y Cajal","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital de la Santa Creu i Sant Pau , Barcelona,","place":["Spain"]},{"name":"Medical Oncology Department, Hospital Cl\u00ednic de Barcelona , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0762-6415","authenticated-orcid":false,"given":"Judith","family":"Balma\u00f1a","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebron Institute of Oncology (VHIO), Vall d\u2019Hebron Barcelona Hospital Campus , Barcelona,","place":["Spain"]},{"name":"Medical Oncology Department, Vall d\u2019Hebron Barcelona Hospital Campus , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"key":"2025081217392885600_djaf067-B1","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1056\/nejmoa2005936","article-title":"A population-based study of genes previously implicated in breast cancer","volume":"384","author":"Hu","year":"2021","journal-title":"N Engl J Med"},{"key":"2025081217392885600_djaf067-B2","doi-asserted-by":"publisher","first-page":"635","DOI":"10.7326\/0003-4819-156-9-201205010-00006","article-title":"Risk factors for breast cancer for women aged 40 to 49 years: a systematic review and meta-analysis","volume":"156","author":"Nelson","year":"2012","journal-title":"Ann Intern Med"},{"key":"2025081217392885600_djaf067-B3","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1016\/S1470-2045(12)70425-4","article-title":"Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies","volume":"13","author":"Collaborative Group on Hormonal Factors in Breast Cancer","year":"2012","journal-title":"Lancet Oncol"},{"key":"2025081217392885600_djaf067-B4","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1002\/ijc.26460","article-title":"Comparison of the effects of genetic and environmental risk factors on in situ and invasive ductal breast cancer","volume":"131","author":"Reeves","year":"2012","journal-title":"Int J Cancer"},{"key":"2025081217392885600_djaf067-B5","doi-asserted-by":"publisher","first-page":"2496","DOI":"10.1158\/1055-9965.EPI-10-0747","article-title":"Oral contraceptive use and breast cancer: a prospective study of young women","volume":"19","author":"Hunter","year":"2010","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2025081217392885600_djaf067-B6","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1093\/jnci\/djq527","article-title":"Breast cancer risk in relation to the interval between menopause and starting hormone therapy","volume":"103","author":"Beral","year":"2011","journal-title":"J Natl Cancer Inst"},{"key":"2025081217392885600_djaf067-B7","doi-asserted-by":"publisher","first-page":"2402","DOI":"10.1001\/jama.2017.7112","article-title":"Risks of breast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers","volume":"317","author":"Kuchenbaecker","year":"2017","journal-title":"J Am Med Assoc"},{"key":"2025081217392885600_djaf067-B8","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1056\/NEJMsr1501341","article-title":"Gene-panel sequencing and the prediction of breast-cancer risk","volume":"372","author":"Easton","year":"2015","journal-title":"N Engl J Med"},{"key":"2025081217392885600_djaf067-B9","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1093\/jnci\/djae208","article-title":"Genetic risk, health-associated lifestyle, and risk of early-onset total cancer and breast cancer","volume":"117","author":"Zhang","year":"2025","journal-title":"J Natl Cancer Inst"},{"key":"2025081217392885600_djaf067-B10","doi-asserted-by":"publisher","first-page":"dju397","DOI":"10.1093\/jnci\/dju397","article-title":"The contributions of breast density and common genetic variation to breast cancer risk","volume":"107","author":"Vachon","year":"2015","journal-title":"J Natl Cancer Inst"},{"key":"2025081217392885600_djaf067-B11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/jnci\/djx051","article-title":"Association of common genetic variants with contralateral breast cancer risk in the WECARE Study","volume":"109","author":"Robson","year":"2017","journal-title":"J Natl Cancer Inst"},{"key":"2025081217392885600_djaf067-B12","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1093\/jnci\/djz174","article-title":"A polygenic risk score for breast cancer in US Latinas and Latin American Women","volume":"112","author":"Shieh","year":"2020","journal-title":"J Natl Cancer Inst"},{"key":"2025081217392885600_djaf067-B13","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ajhg.2018.11.002","article-title":"Polygenic risk scores for prediction of breast cancer and breast cancer subtypes","volume":"104","author":"Mavaddat","year":"2019","journal-title":"Am J Hum Genet"},{"key":"2025081217392885600_djaf067-B14","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1038\/s41436-020-0884-4","article-title":"Validation of the BOADICEA model and a 313-variant polygenic risk score for breast cancer risk prediction in a Dutch prospective cohort","volume":"22","author":"Lakeman","year":"2020","journal-title":"Genet Med"},{"key":"2025081217392885600_djaf067-B15","doi-asserted-by":"publisher","first-page":"djv219","DOI":"10.1093\/jnci\/djv219","article-title":"Height and breast cancer risk: evidence from prospective studies and Mendelian randomization","volume":"107","author":"Zhang","year":"2015","journal-title":"J Natl Cancer Inst"},{"key":"2025081217392885600_djaf067-B16","doi-asserted-by":"publisher","first-page":"635","DOI":"10.7326\/0003-4819-156-9-201205010-00006","article-title":"Risk factors for breast cancer for women aged 40 to 49 years: a systematic review and meta-analysis","volume":"156","author":"Nelson","year":"2012","journal-title":"Ann Intern Med"},{"key":"2025081217392885600_djaf067-B17","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1038\/sj.bjc.6600596","article-title":"Alcohol, tobacco and breast cancer\u2014collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease","volume":"87","author":"Hamajima","year":"2002","journal-title":"Br J Cancer"},{"key":"2025081217392885600_djaf067-B18","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1158\/1055-9965.EPI-20-1319","article-title":"CanRisk tool\u2014a web interface for the prediction of breast and ovarian cancer risk and the likelihood of carrying genetic pathogenic variants","volume":"30","author":"Carver","year":"2021","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2025081217392885600_djaf067-B19","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/S1470-2045(18)30902-1","article-title":"10-year performance of four models of breast cancer risk: a validation study","volume":"20","author":"Terry","year":"2019","journal-title":"Lancet Oncol"},{"key":"2025081217392885600_djaf067-B20","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1038\/s41436-018-0406-9","article-title":"BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors","volume":"21","author":"Lee","year":"2019","journal-title":"Genet Med"},{"key":"2025081217392885600_djaf067-B21","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1158\/1055-9965.epi-22-0756","article-title":"Incorporating alternative polygenic risk scores into the BOADICEA Breast Cancer Risk Prediction Model","volume":"32","author":"Mavaddat","year":"2023","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2025081217392885600_djaf067-B22","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1136\/jmg-2022-108806","article-title":"Prospective validation of the BOADICEA multifactorial breast cancer risk prediction model in a large prospective cohort study","volume":"59","author":"Yang","year":"2022","journal-title":"J Med Genet"},{"key":"2025081217392885600_djaf067-B23","doi-asserted-by":"publisher","first-page":"604","DOI":"10.3390\/cancers15030604","article-title":"Barriers to breast cancer-screening adherence in vulnerable populations","volume":"15","author":"Ponce-Chazarri","year":"2023","journal-title":"Cancers (Basel)"},{"key":"2025081217392885600_djaf067-B24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13690-024-01248-x","article-title":"\u201cFor and against\u201d factors influencing participation in personalized breast cancer screening programs: a qualitative systematic review until March 2022","volume":"82","author":"Laza","year":"2024","journal-title":"Arch Public Health"},{"key":"2025081217392885600_djaf067-B25","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1177\/0272989X15587676","article-title":"Understanding the harms and benefits of cancer screening","volume":"35","author":"Petrova","year":"2015","journal-title":"Med Decis Making"},{"key":"2025081217392885600_djaf067-B26","first-page":"48","author":"NIHCE"},{"key":"2025081217392885600_djaf067-B27","author":"Balaguer","year":"2023"},{"key":"2025081217392885600_djaf067-B28","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.medcli.2010.04.015","article-title":"Versi\u00f3n espa\u00f1ola de la Cancer Worry Scale (Escala de Preocupaci\u00f3n por el C\u00e1ncer: adaptaci\u00f3n cultural y anlisis de la validez y la fiabilidad)","volume":"136","author":"Cabrera","year":"2011","journal-title":"Med Clin (Barc)"},{"key":"2025081217392885600_djaf067-B29","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1177\/0272989X0102100105","article-title":"General performance on a numeracy scale among highly educated samples","volume":"21","author":"Lipkus","year":"2001","journal-title":"Med Decis Making"},{"key":"2025081217392885600_djaf067-B30","doi-asserted-by":"publisher","first-page":"e5542","DOI":"10.7717\/peerj.5542","article-title":"Balanced and positively worded personality short-forms: mini-IPIP validity and cross-cultural invariance","volume":"6","author":"Mart\u00ednez-Molina","year":"2018","journal-title":"PeerJ"},{"key":"2025081217392885600_djaf067-B31","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1037\/1040-3590.18.2.192","article-title":"The mini-IPIP scales: tiny-yet-effective measures of the Big Five factors of personality","volume":"18","author":"Donnellan","year":"2006","journal-title":"Psychol Assess"},{"key":"2025081217392885600_djaf067-B32","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1080\/00223891.2012.700466","article-title":"Psychometric properties of the mini-IPIP in a large, nationally representative sample of young adults","volume":"95","author":"Baldasaro","year":"2013","journal-title":"J Pers Assess"},{"key":"2025081217392885600_djaf067-B33","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1037\/\/0278-6133.21.6.564","article-title":"A brief assessment of concerns associated with genetic testing for cancer: the Multidimensional Impact of Cancer Risk Assessment (MICRA) questionnaire","volume":"21","author":"Cella","year":"2002","journal-title":"Health Psychol"},{"key":"2025081217392885600_djaf067-B34","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1177\/0272989X19851345","article-title":"Decisional conflict scale use over 20 years: the anniversary review","volume":"39","author":"Garvelink","year":"2019","journal-title":"Med Decis Making"},{"key":"2025081217392885600_djaf067-B35","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.4067\/s0034-98872008001100010","article-title":"[Validation of a Spanish version of the Decisional Conflict scale]","volume":"136","author":"Urrutia","year":"2008","journal-title":"Rev Med Chil"},{"key":"2025081217392885600_djaf067-B36","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.ijchp.2017.07.003","article-title":"Short form of the Spanish adaptation of the State-Trait Anxiety Inventory","volume":"17","author":"Buela-Casal","year":"2017","journal-title":"Int J Clin Health Psychol"},{"key":"2025081217392885600_djaf067-B37","doi-asserted-by":"publisher","first-page":"S467","DOI":"10.1002\/acr.20561","article-title":"Measures of anxiety: State-Trait Anxiety Inventory (STAI), Beck Anxiety Inventory (BAI), and Hospital Anxiety and Depression Scale-Anxiety (HADS-A)","volume":"63","author":"Julian","year":"2011","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"2025081217392885600_djaf067-B38","doi-asserted-by":"publisher","first-page":"101928","DOI":"10.1016\/j.cpr.2020.101928","article-title":"Specificity of trait anxiety in anxiety and depression: Meta-analysis of the State-Trait Anxiety Inventory","volume":"82","author":"Knowles","year":"2020","journal-title":"Clin Psychol Rev"},{"key":"2025081217392885600_djaf067-B39","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)\u2014a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J Biomed Inform"},{"key":"2025081217392885600_djaf067-B40","doi-asserted-by":"publisher","first-page":"103208","DOI":"10.1016\/j.jbi.2019.103208","article-title":"The REDCap consortium: building an international community of software platform partners","volume":"95","author":"Harris","year":"2019","journal-title":"J Biomed Inform"},{"key":"2025081217392885600_djaf067-B41","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1111\/cge.13687","article-title":"Uptake of polygenic risk information among women at increased risk of breast cancer","volume":"97","author":"Yanes","year":"2020","journal-title":"Clin Genet"},{"key":"2025081217392885600_djaf067-B42","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.3390\/ijerph19031406","article-title":"Barriers and facilitators to the implementation of a personalized breast cancer screening program: views of Spanish health professionals","volume":"19","author":"Laza-V\u00e1squez","year":"2022","journal-title":"Int J Environ Res Public Health"},{"key":"2025081217392885600_djaf067-B43","doi-asserted-by":"publisher","first-page":"2116","DOI":"10.3390\/cancers16112116","article-title":"Implementing multifactorial risk assessment with polygenic risk scores for personalized breast cancer screening in the population setting: challenges and opportunities","volume":"16","author":"Walker","year":"2024","journal-title":"Cancers (Basel)"},{"key":"2025081217392885600_djaf067-B44","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1136\/jmg-2022-108502","volume-title":"J Med Genet","author":"Lakeman","year":"2022"},{"key":"2025081217392885600_djaf067-B45","doi-asserted-by":"publisher","first-page":"103615","DOI":"10.1016\/j.breast.2023.103615","article-title":"Clinical implications of incorporating genetic and non-genetic risk factors in CanRisk-based breast cancer risk prediction","volume":"73","author":"T\u00fcchler","year":"2024","journal-title":"Breast"},{"key":"2025081217392885600_djaf067-B46","doi-asserted-by":"publisher","first-page":"3938","DOI":"10.3390\/cancers15153938","article-title":"Clinical impact of polygenic risk score for breast cancer risk prediction in 382 individuals with hereditary breast and ovarian cancer syndrome","volume":"15","author":"Stiller","year":"2023","journal-title":"Cancers (Basel)"},{"key":"2025081217392885600_djaf067-B47","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1136\/jmg-2023-109311","article-title":"Integrating a polygenic risk score into a clinical setting would impact risk predictions in familial breast cancer","volume":"61","author":"Baliakas","year":"2024","journal-title":"J Med Genet"},{"key":"2025081217392885600_djaf067-B48","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1200\/JClinOncol.24.00029","article-title":"Toward application of polygenic risk scores to both enhance and deintensify breast cancer screening","volume":"42","author":"Maxwell","year":"2024","journal-title":"J Clin Oncol"},{"key":"2025081217392885600_djaf067-B49","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1093\/jnci\/87.4.286","article-title":"Effects of individualized breast cancer risk counseling: a randomized trial","volume":"87","author":"Lerman","year":"1995","journal-title":"J Natl Cancer Inst"},{"key":"2025081217392885600_djaf067-B50","doi-asserted-by":"publisher","first-page":"2226","DOI":"10.1002\/pon.5211","article-title":"Risk estimation, anxiety, and breast cancer worry in women at risk for breast cancer: a single-arm trial of personalized risk communication","volume":"28","author":"Xie","year":"2019","journal-title":"Psychooncology"},{"key":"2025081217392885600_djaf067-B51","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s10897-015-9869-x","article-title":"Counselees\u2019 expressed level of understanding of the risk estimate and surveillance recommendation are not associated with Breast Cancer Surveillance adherence","volume":"25","author":"Albada","year":"2016","journal-title":"J Genet Couns"},{"key":"2025081217392885600_djaf067-B52","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.breast.2022.05.001","article-title":"Does receiving high or low breast cancer risk estimates produce a reduction in subsequent breast cancer screening attendance? Cohort study","volume":"64","author":"French","year":"2022","journal-title":"Breast"},{"key":"2025081217392885600_djaf067-B53","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1186\/s12885-021-08347-w","article-title":"Extending screening intervals for women at low risk of breast cancer: do they find it acceptable?","volume":"21","author":"McWilliams","year":"2021","journal-title":"BMC Cancer"},{"key":"2025081217392885600_djaf067-B54","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.1038\/s41416-018-0069-y","article-title":"Psychological impact of providing women with personalised 10-year breast cancer risk estimates","volume":"118","author":"French","year":"2018","journal-title":"Br J Cancer"},{"key":"2025081217392885600_djaf067-B55","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1002\/jgc4.1687","article-title":"Role of psychological background in cancer susceptibility genetic testing distress: it is not only about a positive result","volume":"32","author":"L\u00f3pez-Fern\u00e1ndez","year":"2023","journal-title":"J Genet Couns"},{"key":"2025081217392885600_djaf067-B56","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1002\/cncr.33357","article-title":"Psychosocial outcomes following germline multigene panel testing in an ethnically and economically diverse cohort of patients","volume":"127","author":"Culver","year":"2021","journal-title":"Cancer"},{"key":"2025081217392885600_djaf067-B57","doi-asserted-by":"publisher","first-page":"e1940","DOI":"10.1002\/jgc4.1940","article-title":"Psychological distress following multi-gene panel testing for hereditary breast and ovarian cancer risk","volume":"34","author":"Carlsson","year":"2025","journal-title":"J Genet Couns"},{"key":"2025081217392885600_djaf067-B58","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ajhg.2018.11.002","article-title":"Polygenic risk scores for prediction of breast cancer and breast cancer subtypes","volume":"104","author":"Mavaddat","year":"2019","journal-title":"Am J Hum Genet"},{"key":"2025081217392885600_djaf067-B59","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1136\/jmg-2022-108806","article-title":"Prospective validation of the BOADICEA multifactorial breast cancer risk prediction model in a large prospective cohort study","volume":"59","author":"Yang","year":"2022","journal-title":"J Med Genet"},{"key":"2025081217392885600_djaf067-B60","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1038\/s41588-019-0379-x","article-title":"Clinical use of current polygenic risk scores may exacerbate health disparities","volume":"51","author":"Martin","year":"2019","journal-title":"Nat Genet"}],"container-title":["JNCI: Journal of the National Cancer Institute"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jnci\/advance-article-pdf\/doi\/10.1093\/jnci\/djaf067\/62834983\/djaf067.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jnci\/article-pdf\/117\/8\/1593\/62834983\/djaf067.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jnci\/article-pdf\/117\/8\/1593\/62834983\/djaf067.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T21:39:37Z","timestamp":1755034777000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnci\/article\/117\/8\/1593\/8102984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,1]]},"references-count":60,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,4,1]]},"published-print":{"date-parts":[[2025,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jnci\/djaf067","relation":{},"ISSN":["0027-8874","1460-2105"],"issn-type":[{"value":"0027-8874","type":"print"},{"value":"1460-2105","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,8]]},"published":{"date-parts":[[2025,4,1]]}}}