{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T07:23:23Z","timestamp":1782804203863,"version":"3.54.5"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"National Cancer Institute Cancer Center","award":["P30CA008748"],"award-info":[{"award-number":["P30CA008748"]}]},{"name":"Memorial Sloan Kettering Cancer Center\u2019s core resources"},{"name":"National Cancer Institute Surgical Oncology T32 Research Training","award":["T32CA009501-34"],"award-info":[{"award-number":["T32CA009501-34"]}]},{"name":"National Cancer Institute Diversity Supplement to \u201cExpansion of Tumoroid Models for Precise Treatment of the Rectal Cancer Patient\u201d","award":["R37CA248289"],"award-info":[{"award-number":["R37CA248289"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R37CA248289"],"award-info":[{"award-number":["R37CA248289"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K08CA255574"],"award-info":[{"award-number":["K08CA255574"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"AstraZenenca"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The treatment of locally advanced rectal cancer now includes \u201cwatch-and-wait\u201d (WW) management for patients who exhibit a clinical complete response (cCR) to total neoadjuvant therapy (TNT). We assessed patients\u2019 knowledge and preferences regarding WW with the goal of incorporating patient input into clinical trial design.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Rectal cancer patients in advocacy groups (COLONTOWN\/Rectalburgh and Fight CRC) were surveyed regarding perceptions about treatment strategies, tolerable risks of treatment failure, and preferences on clinical trial design. Surveys were initially distributed in 2019, with the shift toward WW prompting re-survey of select questions in 2023.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>All respondents preferred enrollment in trials that incorporated patient input. Most respondents (76%) preferred treatment that incorporated chemotherapy escalation over radiation escalation. Furthermore, when presented with a hypothetical patient who developed a cCR after chemoradiation (without the option for WW), 58% of patients chose surgical treatment (with 100% risk of permanent ostomy and 80% chance of cure) over omission of surgery (with &amp;lt;80% chance of cure). In contrast, when the hypothetical patient developed a cCR after TNT (with an option for WW), 82% of patients opted for selective WW over surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This work successfully integrated patient advocacy groups as a resource for obtaining patient input. Surveys revealed patients had a strong preference for chemotherapy escalation, for selective WW when offered, and for incorporation of input into future clinical trial design. These findings describe how well-informed patients approach complex medical decision-making and serve as a starting point for future studies seeking to incorporate patient voices.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jnci\/djaf074","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T04:22:21Z","timestamp":1742444541000},"page":"1421-1428","source":"Crossref","is-referenced-by-count":4,"title":["Utilizing Patient Input in Rectal Cancer Trial Design"],"prefix":"10.1093","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7853-959X","authenticated-orcid":false,"given":"Janet","family":"Alvarez","sequence":"first","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center , New York, NY,","place":["United 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