{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T13:20:10Z","timestamp":1788009610394,"version":"build-2784847793"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T00:00:00Z","timestamp":1743379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"NCTN Operations Center","award":["U10CA180886"],"award-info":[{"award-number":["U10CA180886"]}]},{"name":"NCTN Statistics & Data Center","award":["U10CA180899"],"award-info":[{"award-number":["U10CA180899"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"NCI","doi-asserted-by":"publisher","award":["K08 CA245036"],"award-info":[{"award-number":["K08 CA245036"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Understanding the patient experience of treatment toxicities and their impact on health-related quality of life from cancer treatments requires asking patients using patient-reported outcomes. Over the past 20 years, the National Institutes of Health has sponsored several tools\u2014namely, Patient-Reported Outcomes Measurement Information System measures and the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events\u2014for precisely this purpose: to ensure valid, reliable tools to collect and detect patient-reported toxicities or adverse events and their impact on health-related quality of life. These patient-reported outcomes measures have been widely incorporated in clinical trials for adults with cancer. Yet, despite considerable work developing and validating developmentally appropriate versions of these measures for pediatric and adolescent self-report, patient-reported outcomes inclusion in pediatric and adolescent and young adult clinical trials has lagged. Here, we discuss optimal strategies to integrate validated patient-reported outcomes tools and sound analytic methodologies in clinical trials for children and adolescent and young adults with cancer, highlighting lessons learned from recent successes and ongoing experiences developing and opening cross-network trials for children and adolescent and young adults through the Children\u2019s Oncology Group for patients with classic Hodgkin lymphoma, osteosarcoma, and acute lymphoblastic leukemia.<\/jats:p>","DOI":"10.1093\/jnci\/djaf083","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T17:36:38Z","timestamp":1743356198000},"page":"1764-1773","source":"Crossref","is-referenced-by-count":6,"title":["Incorporation of patient-reported outcomes in pediatric cancer clinical trials: design, implementation, and dissemination"],"prefix":"10.1093","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7591-2245","authenticated-orcid":false,"given":"Katie A","family":"Greenzang","sequence":"first","affiliation":[{"name":"Department of Pediatric Oncology, Dana-Farber Cancer Institute , Boston, MA,","place":["United States"]},{"name":"Division of Pediatric Hematology\/Oncology, Boston Children\u2019s Hospital , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7662-0247","authenticated-orcid":false,"given":"Kathleen E","family":"Montgomery","sequence":"additional","affiliation":[{"name":"University of Wisconsin\u2013Madison School of Nursing , Madison, WI,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9163-8792","authenticated-orcid":false,"given":"Adam","family":"DuVall","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Chicago , Chicago, IL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6411-8353","authenticated-orcid":false,"given":"Michael E","family":"Roth","sequence":"additional","affiliation":[{"name":"Division of Pediatrics, Department of Pediatrics Patient Care, The University of Texas MD Anderson Cancer Center , Houston, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Krailo","sequence":"additional","affiliation":[{"name":"Department of Population and Public Health Sciences, University of Southern California , Los Angeles, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2031-929X","authenticated-orcid":false,"given":"Michelle M","family":"Nu\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Population and Public Health Sciences, University of Southern California , Los Angeles, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4306-1896","authenticated-orcid":false,"given":"Lindsay","family":"Renfro","sequence":"additional","affiliation":[{"name":"Department of Population and Public Health Sciences, University of Southern California , Los Angeles, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8139-9839","authenticated-orcid":false,"given":"Natalie","family":"DelRocco","sequence":"additional","affiliation":[{"name":"Department of Population and Public Health Sciences, University of Southern California , Los Angeles, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Doski","sequence":"additional","affiliation":[{"name":"Departments of Surgery and Pediatrics, University of Texas Health Science Center, San Antonio , San Antonio, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1473-3937","authenticated-orcid":false,"given":"Kara","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Roswell Park Comprehensive Cancer Center , Buffalo, NY,","place":["United States"]},{"name":"Department of Pediatrics, University at Buffalo Jacobs School of Medicine and Biomedical Sciences , Buffalo, NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon M","family":"Castellino","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Emory School of Medicine , Atlanta, GA,","place":["United States"]},{"name":"Aflac Cancer and Blood Disorders Center, Children\u2019s Healthcare of Atlanta , Atlanta, GA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4743-6325","authenticated-orcid":false,"given":"Jennifer","family":"McNeer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Utah\/Primary Children\u2019s Hospital , Salt Lake City, UT,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9054-4321","authenticated-orcid":false,"given":"Maureen M","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children\u2019s Hospital Colorado; University of Colorado Anschutz School of Medicine , Denver, CO,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8238-2465","authenticated-orcid":false,"given":"Damon","family":"Reed","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Memorial Sloan Kettering 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