{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:51:49Z","timestamp":1791874309417,"version":"4.3.4"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T00:00:00Z","timestamp":1746835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA184075"],"award-info":[{"award-number":["R01 CA184075"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA015704"],"award-info":[{"award-number":["P30 CA015704"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P50 CA097186"],"award-info":[{"award-number":["P50 CA097186"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R50 CA221836"],"award-info":[{"award-number":["R50 CA221836"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Veterans Affairs Merit Award","award":["I01BX003324"],"award-info":[{"award-number":["I01BX003324"]}]},{"name":"Edmonds MOB Mother-Son Superhero Dance"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Adiposity reduction has cancer-specific and overall health benefits for patients with overweight or obesity. The indiscriminate loss of lean mass accompanying weight loss, however, remains a concern for older patients with cancer. Body composition was evaluated in the Prostate Cancer Active Lifestyle Study, a randomized controlled weight loss trial targeting caloric restriction and increased physical activity among patients with prostate cancer and overweight or obesity on active surveillance. Compared with control individuals, the intervention statistically significantly decreased total fat (\u20123.4%, 95% CI\u2009=\u2009\u20125.3% to \u20121.5%), android fat (\u20122.0%, 95% CI\u2009=\u2009\u20123.6% to \u20120.4%), and visceral adipose tissue mass (\u2012613\u2009g, 95% CI\u2009=\u2009\u2012894 to \u2012331\u2009g) (all 2-sided P\u2009&amp;lt;\u2009.001), with no difference in lean mass (P\u2009=\u2009.70) and a statistically significant increase in lean mass to fat ratio (0.40, 95% CI\u2009=\u20090.06 to 0.73; 2-sided P\u2009=\u2009.02). Weight loss interventions incorporating diet and physical activity among patients with prostate cancer and overweight or obesity can yield statistically significant reductions in adiposity while limiting lean mass loss.<\/jats:p>","DOI":"10.1093\/jnci\/djaf113","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T07:26:21Z","timestamp":1746689181000},"page":"2682-2686","source":"Crossref","is-referenced-by-count":4,"title":["Reduced adipose tissue with limited loss of lean mass after weight loss: results from the Prostate Cancer Active Lifestyle Study"],"prefix":"10.1093","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4865-7813","authenticated-orcid":false,"given":"Jeannette M","family":"Schenk","sequence":"first","affiliation":[{"name":"Public Health Sciences, Fred Hutchinson Cancer Center , Seattle, WA,","place":["United 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