{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T20:11:50Z","timestamp":1757621510236,"version":"3.44.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-159467","EDC-186610"],"award-info":[{"award-number":["PJT-159467","EDC-186610"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100021638","name":"Social Sciences and Humanities Research Council","doi-asserted-by":"publisher","award":["767-2021-2468"],"award-info":[{"award-number":["767-2021-2468"]}],"id":[{"id":"10.13039\/100021638","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Colorectal cancer (CRC) affects a growing number of females. Our objective was to evaluate the impact of CRC on sexual health outcomes among females, while controlling for age.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a cohort study using administrative health data from the province of British Columbia (BC) including linked health visits and cancer registry from 1985 to 2017. The cohort included females with CRC (n\u2009=\u200925\u00a0402; mean age [SD]: 69.0 [13.1]) and matched controls without CRC (n\u2009=\u2009254\u00a0020; 69.0 [13.1]) in a 1:10 ratio by age, further stratified by age groups (\u226439\u2009years and \u226540\u2009years). Multivariable Cox regression models assessed the associations between CRC and 5 sexual health outcomes (dyspareunia, pelvic inflammatory disease, endometriosis, abnormal bleeding, and premature ovarian failure), adjusting for covariates. Sensitivity analyses focused on females with CRC to explore associations between sociodemographic and cancer-related factors and sexual health outcomes. Tests were 2-sided (statistical significance P\u2009&amp;lt;.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Females with CRC had higher risks of dyspareunia (HR 1.67; 95% CI = 1.62 to 1.73), pelvic inflammatory disease (HR 3.42; 95% CI = 3.07 to 3.81), and endometriosis (HR 1.95; 95% CI = 1.69 to 2.25) compared to controls. In the \u226540-year group, these associations persisted, while in the \u226439-year group, endometriosis was not associated with CRC, but premature ovarian failure was (HR 1.75; 95% CI = 1.40 to 2.19). In sensitivity analyses, we also observed associations with cancer treatments (surgery, chemotherapy, radiation) and sexual health outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This population-based study identified associations between CRC and adverse sexual health outcomes among female patients, highlighting the need for targeted interventions and support.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jnci\/djaf120","type":"journal-article","created":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T20:02:07Z","timestamp":1748721727000},"page":"1817-1824","source":"Crossref","is-referenced-by-count":0,"title":["Sexual health outcomes after colorectal cancer diagnosis in females: a population-based cohort 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BC,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8243-8721","authenticated-orcid":false,"given":"Stuart","family":"Peacock","sequence":"additional","affiliation":[{"name":"BC Cancer , Vancouver, BC,","place":["Canada"]},{"name":"Faculty of Health Sciences, Simon Fraser University , Burnaby, BC,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meera","family":"Rayar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of British Columbia , Vancouver, BC,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8903-0040","authenticated-orcid":false,"given":"Amirrtha","family":"Srikanthan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Ottawa , Ottawa, ON,","place":["Canada"]},{"name":"Department of Medicine, Division of Medical Oncology, The Ottawa Hospital , 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