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We conducted multivariable-adjusted, time-varying Cox proportional hazards regression models to assess ASCVD risk following an individual\u2019s cancer diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During up to 36\u2009years of follow-up, 4334 new-onset ASCVD events among 49\u200a603 incident cancer cases were documented. After adjusting for shared risk factors, cervical cancer (hazard ratio\u2009[HR] =\u20091.56, 95% confidence interval [CI]\u2009=\u20091.06 to 2.29) and Hodgkin lymphoma (HR\u2009=\u20092.80, 95% CI\u2009=\u20091.89 to 4.15) was associated with increased risk of ASCVD incidence, whereas prostate cancer was associated with a lower ASCVD incidence (HR\u2009=\u20090.91, 95% CI\u2009=\u20090.85 to 0.97). Compared with cancer-free individuals, breast cancer survivors experienced lower ASCVD risk during the first 7.5\u2009years, but risk gradually increased afterward (Pnonlinearity\u2009=\u2009.01). The risk of ASCVD increased over time among patients with cancers of the colorectum (P\u2009=\u2009.003), lung (P\u2009=\u2009.002), and endometrium (P\u2009=\u2009.04). No statistically significant association with ASCVD risk was observed for cancers of the oral cavity and pharynx, kidney, or ovary; sarcoma; melanoma; or leukemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cervical cancer and Hodgkin lymphoma were associated with an increased risk of new-onset ASCVD, independent of shared risk factors. No increased risk was found with other cancers. Risk trajectories of ASCVD varied over time after diagnosis by cancer type.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jnci\/djaf122","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T09:14:38Z","timestamp":1747818878000},"page":"1707-1716","source":"Crossref","is-referenced-by-count":2,"title":["Risk of atherosclerotic cardiovascular disease after cancer diagnosis: findings from 3 prospective cohort studies"],"prefix":"10.1093","volume":"117","author":[{"given":"Qiang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Breast Surgical Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing,","place":["China"]},{"name":"Department of Nutrition, Harvard T.H. Chan School of Public Health , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4152-7821","authenticated-orcid":false,"given":"Qiaoli","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5614-5618","authenticated-orcid":false,"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8784-9001","authenticated-orcid":false,"given":"Han","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Harvard T.H. Chan School of Public Health , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health , Boston, MA,","place":["United States"]},{"name":"Channing Division of Network Medicine, Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School , Boston, MA,","place":["United States"]},{"name":"Department of Biostatistics, Harvard T.H. Chan School of Public Health , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3224-3993","authenticated-orcid":false,"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Breast Surgical Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1324-0316","authenticated-orcid":false,"given":"Mingyang","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Harvard T.H. Chan School of Public Health , Boston, MA,","place":["United States"]},{"name":"Department of Epidemiology, Harvard T.H. 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