{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T15:52:16Z","timestamp":1782316336085,"version":"3.54.5"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"11","funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Departement of Heath and Human Services"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Gastric cancer remains a major health challenge globally. In the United States, gastric cancer outcomes remain poor, with well-documented disparities in incidence and mortality. In 2024, the US National Cancer Institute convened a Think Tank on Advancing Gastric Cancer Prevention, with participation of over 200 global leaders from academia, clinical practice, and industry as well as patient advocates to exchange knowledge, lived experiences, and discuss future research opportunities. This commentary summarizes the Think Tank presentations and discussions of key existing evidence as well as challenges and opportunities for the prevention and control of this preventable disease. Primary prevention discussions focused on the use of the screen-and-treat strategy for Helicobacter pylori eradication. Secondary prevention discussions included endoscopic screening and surveillance of advanced gastric precancerous lesions. Primary conclusions for gastric cancer prevention and control included the need for (1) developing large-scale study resources that optimize the ability to conduct research with potential clinical translation applications; (2) strengthening and building community-public health-academic partnerships to enhance research; and (3) leveraging evidence-based strategies developed in high-risk East Asian countries to high-risk subgroups in low- and moderate-risk countries including the United States. There was overwhelming agreement that given the current state of gastric cancer incidence and survival in the United States, novel strategies to control the carcinogenic effects of H. pylori and to improve detection of precursors are the key to substantially reducing the burden of this disease.<\/jats:p>","DOI":"10.1093\/jnci\/djaf172","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T07:39:45Z","timestamp":1751355585000},"page":"2169-2174","source":"Crossref","is-referenced-by-count":2,"title":["A summary of the National Cancer Institute Think Tank on Advancing Gastric Cancer Prevention"],"prefix":"10.1093","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1065-2198","authenticated-orcid":false,"given":"M Constanza","family":"Camargo","sequence":"first","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health , Rockville, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3008-7843","authenticated-orcid":false,"given":"Christian C","family":"Abnet","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health , Rockville, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6334-6936","authenticated-orcid":false,"given":"Jeremy L","family":"Davis","sequence":"additional","affiliation":[{"name":"Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5558-2744","authenticated-orcid":false,"given":"Cecilia","family":"Monge","sequence":"additional","affiliation":[{"name":"Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9192-2013","authenticated-orcid":false,"given":"Tram Kim","family":"Lam","sequence":"additional","affiliation":[{"name":"Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health , Rockville, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish","family":"Gopal","sequence":"additional","affiliation":[{"name":"Center for Global Health, National Cancer Institute, National Institutes of Health , Rockville, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8355-2668","authenticated-orcid":false,"given":"Matthew","family":"Young","sequence":"additional","affiliation":[{"name":"Division of Cancer Prevention, National Cancer Institute, National Institutes of Health , Rockville, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3390-751X","authenticated-orcid":false,"given":"Phil","family":"Daschner","sequence":"additional","affiliation":[{"name":"Division of Cancer Biology, National Cancer Institute, National Institutes of Health , Rockville, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6995-8725","authenticated-orcid":false,"given":"Tiffany A","family":"Wallace","sequence":"additional","affiliation":[{"name":"Center to Reduce Cancer Health Disparities, National Cancer Institute, National Institutes of Health , Rockville, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luz Mar\u00eda","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Division of Cancer Prevention, National Cancer Institute, National Institutes of Health , Rockville, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6408-5985","authenticated-orcid":false,"given":"Philip E","family":"Castle","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health , Rockville, MD,","place":["United States"]},{"name":"Division of Cancer Prevention, National Cancer Institute, National Institutes of Health , Rockville, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6239-8494","authenticated-orcid":false,"given":"Asad","family":"Umar","sequence":"additional","affiliation":[{"name":"Division of Cancer Prevention, National Cancer Institute, National Institutes of Health , Rockville, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5855-5047","authenticated-orcid":false,"given":"Ellen","family":"Richmond","sequence":"additional","affiliation":[{"name":"Division of Cancer Prevention, National Cancer Institute, National Institutes of Health , Rockville, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"2025110923125589700_djaf172-B1","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1002\/ijc.35278","article-title":"The GLOBOCAN 2022 cancer estimates: data sources, methods, and a snapshot of the cancer burden worldwide","volume":"156","author":"Filho","year":"2025","journal-title":"Int J Cancer"},{"key":"2025110923125589700_djaf172-B2","author":"SEER Cancer Stat Facts: Stomach Cancer","year":"2025"},{"key":"2025110923125589700_djaf172-B3","doi-asserted-by":"publisher","first-page":"221","DOI":"10.5230\/jgc.2021.21.e27","article-title":"Korean Gastric Cancer Association-led nationwide survey on surgically treated gastric cancers in 2019","volume":"21","author":"Information Committee of the Korean Gastric Cancer Association","year":"2021","journal-title":"J Gastric Cancer"},{"key":"2025110923125589700_djaf172-B4","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1093\/jnci\/djx262","article-title":"The changing face of noncardia gastric cancer incidence among US non-Hispanic Whites","volume":"110","author":"Anderson","year":"2018","journal-title":"J Natl Cancer Inst"},{"key":"2025110923125589700_djaf172-B5","author":"SEERExplorer: an interactive website for SEER cancer statistics [Internet]","year":"2024"},{"key":"2025110923125589700_djaf172-B6","author":"SEER Cancer Statistics Factsheets: Common Cancer Sites","year":"2025"},{"key":"2025110923125589700_djaf172-B7","doi-asserted-by":"publisher","first-page":"3285","DOI":"10.1016\/j.cgh.2023.01.037","article-title":"Epidemiology of gastric malignancies 2000-2018 according to histology: a population-based analysis of incidence and temporal trends","volume":"21","author":"Rustgi","year":"2023","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2025110923125589700_djaf172-B8","doi-asserted-by":"publisher","first-page":"e2428828","DOI":"10.1001\/jamanetworkopen.2024.28828","article-title":"Incidence and survival outcomes of gastrointestinal stromal tumors","volume":"7","author":"Alvarez","year":"2024","journal-title":"JAMA Netw Open"},{"key":"2025110923125589700_djaf172-B9","doi-asserted-by":"publisher","first-page":"100890","DOI":"10.1016\/j.lana.2024.100890","article-title":"Helicobacter pylori infection in the United States beyond NHANES: a scoping review of seroprevalence estimates by racial and ethnic groups","volume":"41","author":"McMahon","year":"2025","journal-title":"Lancet Reg Health Am"},{"key":"2025110923125589700_djaf172-B10","doi-asserted-by":"publisher","first-page":"100877","DOI":"10.1016\/j.lana.2024.100877","article-title":"Birth cohort and age-specific trends in global Helicobacter pylori seroprevalence: a scoping review","volume":"41","author":"Taylor","year":"2025","journal-title":"Lancet Reg Health Am"},{"key":"2025110923125589700_djaf172-B11","author":"National Cancer Institute, Clinical Trials and Translational Research Advisory Committee Gastric & Esophageal Cancers Working Group Report","year":"2022"},{"key":"2025110923125589700_djaf172-B12","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1053\/j.gastro.2024.12.033","article-title":"Eradication therapy to prevent gastric cancer in Helicobacter pylori-positive individuals: systematic review and meta-analysis of randomized controlled trials and observational studies","volume":"169","author":"Ford","year":"2025","journal-title":"Gastroenterology"},{"key":"2025110923125589700_djaf172-B13","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.14309\/ajg.0000000000002968","article-title":"ACG clinical guideline: treatment of Helicobacter pylori infection","volume":"119","author":"Chey","year":"2024","journal-title":"Am J Gastroenterol"},{"key":"2025110923125589700_djaf172-B14","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1136\/gutjnl-2021-325630","article-title":"Chinese consensus report on family-based Helicobacter pylori infection control and management (2021 edition)","volume":"71","author":"Ding","year":"2022","journal-title":"Gut"},{"key":"2025110923125589700_djaf172-B15","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/s0140-6736(96)01501-2","article-title":"Modelling cost-effectiveness of Helicobacter pylori screening to prevent gastric cancer: a mandate for clinical trials","volume":"348","author":"Parsonnet","year":"1996","journal-title":"Lancet"},{"key":"2025110923125589700_djaf172-B16","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/j.bpg.2013.09.005","article-title":"Cost-effectiveness of screening and treating Helicobacter pylori for gastric cancer prevention","volume":"27","author":"Lansdorp-Vogelaar","year":"2013","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"2025110923125589700_djaf172-B17","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1053\/j.gastro.2021.08.042","article-title":"Testing and treating Helicobacter pylori infection in individuals with family history of gastric cancer is cost-effective","volume":"161","author":"Rustgi","year":"2021","journal-title":"Gastroenterology"},{"key":"2025110923125589700_djaf172-B18","doi-asserted-by":"publisher","first-page":"e70039","DOI":"10.1111\/hel.70039","article-title":"The optimal age of Helicobacter pylori screen-and-treat for gastric cancer prevention in the United States","volume":"30","author":"M\u00fclder","year":"2025","journal-title":"Helicobacter"},{"key":"2025110923125589700_djaf172-B19","author":"Park","year":"2025"},{"key":"2025110923125589700_djaf172-B20","doi-asserted-by":"publisher","first-page":"2062","DOI":"10.1136\/gutjnl-2024-332815","article-title":"Stomach microbiota in gastric cancer development and clinical implications","volume":"73","author":"Zeng","year":"2024","journal-title":"Gut"},{"key":"2025110923125589700_djaf172-B21","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1053\/j.gastro.2024.11.001","article-title":"AGA clinical practice update on screening and surveillance in individuals at increased risk for gastric cancer in the United States: expert review","volume":"168","author":"Shah","year":"2025","journal-title":"Gastroenterology"},{"key":"2025110923125589700_djaf172-B22","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1053\/j.gastro.2018.04.026","article-title":"Endoscopic screening in Asian countries is associated with reduced gastric cancer mortality: a meta-analysis and systematic review","volume":"155","author":"Zhang","year":"2018","journal-title":"Gastroenterology"},{"key":"2025110923125589700_djaf172-B23","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3949\/ccjm.91a.23015","article-title":"Gastric intestinal metaplasia and gastric cancer prevention: watchful waiting","volume":"91","author":"Khazaaleh","year":"2024","journal-title":"Cleve Clin J Med"},{"key":"2025110923125589700_djaf172-B24","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1002\/ueg2.12759","article-title":"Surveillance of Barrett's esophagus patients in an expert center is associated with low disease-specific mortality","volume":"13","author":"Honing","year":"2025","journal-title":"United European Gastroenterol J"},{"key":"2025110923125589700_djaf172-B25","doi-asserted-by":"publisher","first-page":"e70790","DOI":"10.1002\/cam4.70790","article-title":"Novel and effective blood-based miRNA diagnostic panel for gastric cancer: a pilot study in a Japanese population","volume":"14","author":"Murano","year":"2025","journal-title":"Cancer Med"},{"key":"2025110923125589700_djaf172-B26","doi-asserted-by":"publisher","first-page":"841","DOI":"10.4143\/crt.2019.151","article-title":"Autoimmune diseases and gastric cancer risk: a systematic review and meta-analysis","volume":"51","author":"Song","year":"2019","journal-title":"Cancer Res Treat"},{"key":"2025110923125589700_djaf172-B27","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1001\/jamaoncol.2021.5395","article-title":"Association of antiparietal cell and anti-intrinsic factor antibodies with risk of gastric cancer","volume":"8","author":"Song","year":"2022","journal-title":"JAMA Oncol"},{"key":"2025110923125589700_djaf172-B28","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.gie.2024.08.023","article-title":"Quality indicators for upper GI endoscopy","volume":"101","author":"Yadlapati","year":"2025","journal-title":"Gastrointest Endosc"},{"key":"2025110923125589700_djaf172-B29","doi-asserted-by":"publisher","first-page":"290","DOI":"10.14309\/ajg.0000000000003252","article-title":"Quality indicators for upper GI endoscopy","volume":"120","author":"Yadlapati","year":"2025","journal-title":"Am J Gastroenterol"},{"key":"2025110923125589700_djaf172-B30","doi-asserted-by":"publisher","first-page":"709","DOI":"10.14309\/ajg.0000000000003350","article-title":"ACG clinical guideline: diagnosis and management of gastric premalignant conditions","volume":"120","author":"Morgan","year":"2025","journal-title":"Am J Gastroenterol"},{"key":"2025110923125589700_djaf172-B31","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1056\/NEJMoa1708423","article-title":"Helicobacter pylori therapy for the prevention of metachronous gastric cancer","volume":"378","author":"Choi","year":"2018","journal-title":"N Engl J Med"},{"key":"2025110923125589700_djaf172-B32","doi-asserted-by":"publisher","first-page":"1393498","DOI":"10.3389\/fmed.2024.1393498","article-title":"Helicobacter pylori eradication following endoscopic resection might prevent metachronous gastric cancer: a systematic review and meta-analysis of studies from Japan and Korea","volume":"11","author":"Yu","year":"2024","journal-title":"Front Med (Lausanne)"},{"key":"2025110923125589700_djaf172-B33","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1001\/jama.2024.14887","article-title":"Screening for Helicobacter pylori to prevent gastric cancer: a pragmatic randomized clinical trial","volume":"332","author":"Lee","year":"2024","journal-title":"JAMA"},{"key":"2025110923125589700_djaf172-B34","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1001\/jama.2024.8611","article-title":"Fecal immunochemical test and Helicobacter pylori stool antigen co-testing: a potential approach for gastric cancer screening","volume":"332","author":"Camargo","year":"2024","journal-title":"JAMA"}],"container-title":["JNCI: Journal of the National Cancer Institute"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jnci\/advance-article-pdf\/doi\/10.1093\/jnci\/djaf172\/63647642\/djaf172.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jnci\/article-pdf\/117\/11\/2169\/63647642\/djaf172.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jnci\/article-pdf\/117\/11\/2169\/63647642\/djaf172.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T04:13:02Z","timestamp":1762747982000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnci\/article\/117\/11\/2169\/8182497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,2]]},"references-count":34,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,7,2]]},"published-print":{"date-parts":[[2025,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jnci\/djaf172","relation":{},"ISSN":["0027-8874","1460-2105"],"issn-type":[{"value":"0027-8874","type":"print"},{"value":"1460-2105","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,11]]},"published":{"date-parts":[[2025,7,2]]}}}