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Whether the distribution of adiposity plays a similar role is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used 2-sample Mendelian randomization (MR) to examine causal relationships of 5 adiposity distribution traits (abdominal subcutaneous adipose tissue (ASAT); visceral adipose tissue (VAT); gluteofemoral adipose tissue (GFAT); liver fat; and pancreas fat) with the risks of 12 obesity-related cancers (endometrial, ovarian, breast, colorectal, pancreas, multiple myeloma, liver, kidney (renal cell), thyroid, gallbladder, esophageal adenocarcinoma, and meningioma).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sample size across all genome-wide association studies (GWAS) ranged from 8407 to 728\u200a896 (median: 57\u200a249). We found evidence that higher genetically predicted ASAT increased the risks of endometrial cancer, liver cancer, and esophageal adenocarcinoma (odds ratios (OR) and 95% confidence intervals (CI) per standard deviation (SD) higher ASAT\u2009=\u20091.79 (1.18 to 2.71), 3.83 (1.39 to 10.53), and 2.34 (1.15 to 4.78), respectively). Conversely, we found evidence that higher genetically predicted GFAT decreased the risks of breast cancer and meningioma (ORs and 95% CIs per SD higher genetically predicted GFAT\u2009=\u20090.77 (0.62 to 0.97) and 0.53 (0.32 to 0.90), respectively). We also found evidence for an effect of higher genetically predicted VAT and liver fat on increased liver cancer risk (ORs and 95% CIs per SD higher genetically predicted adiposity trait\u2009=\u20094.29 (1.41 to 13.07) and 4.09 (2.29 to 7.28), respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Our analyses provide novel insights into the relationship between adiposity distribution and cancer risk. These insights highlight the potential importance of adipose tissue distribution alongside maintaining a healthy weight for cancer prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jnci\/djaf201","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T11:57:54Z","timestamp":1757678274000},"page":"2621-2642","source":"Crossref","is-referenced-by-count":8,"title":["Adiposity distribution and risks of 12 obesity-related cancers: a Mendelian randomization analysis"],"prefix":"10.1093","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4888-6037","authenticated-orcid":false,"given":"Emma","family":"Hazelwood","sequence":"first","affiliation":[{"name":"MRC Integrative Epidemiology Unit, University of Bristol , Bristol,","place":["United Kingdom"]},{"name":"Population Health Sciences, Bristol Medical School, University of Bristol , Bristol,","place":["United 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