{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:13:46Z","timestamp":1792120426588,"version":"4.4.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"11","funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["ZIA CP010125\u201328"],"award-info":[{"award-number":["ZIA CP010125\u201328"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institutes of Health Office of Research on Women\u2019s Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are persistent, widespread environmental contaminants, and some are endocrine disrupting. Studies of gynecologic cancers are limited; we evaluated ovarian cancer, a rare, often fatal malignancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This nested case-control study included 318 ovarian cancer cases and 472 individually matched female controls in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, which recruited participants aged 55-74\u2009years from 10 US study centers (1993-2001). We looked at cases through 2016 and quantitated 8 PFAS in prediagnostic serum samples. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) for continuous (log2-transformed) and categorized PFAS concentrations by using conditional logistic regression models, implicitly adjusting for matching factors (age, center, year of random assignment, year of blood draw, race and ethnicity) and adjusting for smoking, body mass index, family history of cancer, menopausal hormone therapy and oral contraceptive use, parity, and number of freeze-thaw cycles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found a positive association with ovarian cancer for a doubling in 2-(N-methyl-perfluorooctane sulfonamido) acetic acid (MeFOSAA) concentrations (OR for log2\u2009=\u20091.24, 95% CI\u2009=\u20091.03 to 1.49) and 62% greater risk among those in the highest quartile (OR for quartile 4 vs quartile 1\u2009=\u20091.62, 95% CI\u2009=\u20091.03 to 2.54; P for trend\u2009=\u2009.02). Perfluorooctane sulfonic acid (PFOS) was associated with increased risk (OR for log2\u2009=\u20091.47, 95% CI\u2009=\u20091.05 to 2.06), with no quartile trend (P for trend\u2009=\u2009.79). Associations with perfluorononanoic acid (OR for log2\u2009=\u20091.36, 95% CI\u2009=\u20090.95 to 1.95) and perfluorodecanoic acid (OR for log2\u2009=\u20091.35, 95% CI\u2009=\u20090.94 to 1.95) were suggested, with nonmonotonic quartile trends (P for trend\u2009=\u2009.12 to .21). The MeFOSAA associations were strongest in women aged 55-59\u00a0years (OR for log 2\u2009=\u20091.60, 95% CI\u2009=\u20091.13 to 2.27), more moderate in women aged 60-64\u00a0years (OR for log2\u2009=\u20091.31, 95% CI\u2009=\u20090.90 to 1.90), and null among women 65\u00a0years of age and older (OR for log2\u2009=\u20091.02, 95% CI\u2009=\u20090.73 to 1.43; P for heterogeneity\u2009=\u2009.22). Associations persisted in cases diagnosed 8\u2009years or more after blood collection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings offer novel evidence for PFAS as ovarian cancer risk factors, particularly PFOS and MeFOSAA, a PFOS precursor.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jnci\/djaf204","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T11:25:21Z","timestamp":1753701921000},"page":"2272-2279","source":"Crossref","is-referenced-by-count":5,"title":["Serum concentrations of perfluoroalkyl and polyfluoroalkyl substances and risk of ovarian cancer"],"prefix":"10.1093","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1294-1679","authenticated-orcid":false,"given":"Rena R","family":"Jones","sequence":"first","affiliation":[{"name":"Occupational & Environmental Epidemiology Branch, 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