{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:06:38Z","timestamp":1792785998758,"version":"4.5.0"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"2","funder":[{"name":"Childhood Cancer Data Initiative"},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Central upon the Official Date of Publication"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The Molecular Characterization Initiative (MCI), a key effort of the National Cancer Institute\u2019s Childhood Cancer Data Initiative (CCDI), was launched in 2022 in collaboration with the Children\u2019s Oncology Group (COG) to bring comprehensive genomic and molecular profiling to children, adolescents, and young adults diagnosed with cancer. The MCI provides paired tumor and germline molecular testing, with results returned to clinicians to inform care. Deidentified data are made available to the research community through the CCDI Data Ecosystem to facilitate the discovery of new treatment strategies. This commentary outlines the MCI\u2019s development, key accomplishments to date, and its role in laying the foundation for standardized clinical diagnostics in pediatric oncology.<\/jats:p>","DOI":"10.1093\/jnci\/djaf214","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T11:38:39Z","timestamp":1754393919000},"page":"199-204","source":"Crossref","is-referenced-by-count":10,"title":["Childhood cancer data initiative: expanded access to tumor molecular profiling for children, adolescents, and young adults"],"prefix":"10.1093","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7001-9071","authenticated-orcid":false,"given":"Joseph","family":"Flores-Toro","sequence":"first","affiliation":[{"name":"National Cancer Institute , Bethesda, MD,","place":["United 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