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Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012538","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to investigate the association between alcohol consumption and squamous cell cancers of the upper aerodigestive tract (UADT), using data from 28 cohorts within the Pooling Project of Prospective Studies of Diet and Cancer (DCPP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Individual-level data from 2\u00a0365\u00a0437 participants were pooled. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox models to quantify the association between alcohol consumption (g\/day) and UADT cancer risk, adjusting for potential confounders. Analyses were conducted by sex, smoking status, geographic region, and alcoholic beverages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over a median follow-up of 15.5\u2009years, 6903 UADT cancer cases were identified. Alcohol consumption was positively associated with UADT cancer risk overall. Even at intakes as low as 5\u2013&amp;lt;15\u2009g\/day, the HR estimate was 1.12 (95% CI = 1.03 to 1.21) compared with the reference group (0.1-&amp;lt;5\u2009g\/day). The HR10\u00a0g\/day (95% CI) was 1.16 (1.14 to 1.18) for women and 1.12 (1.11 to 1.13) for men (Pheterogeneity &amp;lt; .0001). HR10\u00a0g\/day estimates were 1.14 (1.13 to 1.15) in current, 1.10 (1.09 to 1.12) in former, and 1.15 (1.12 to 1.18) in never smokers. Consistent UADT HR10\u00a0g\/day estimates were observed across all beverage types. HR10\u00a0g\/day estimates varied across geographic regions, with HR10\u00a0g\/day (95% CI) equal to 1.15 (1.14 to 1.17) in Europe\u2013Australia, 1.13 (1.11 to 1.15) in Asia, and 1.11 (1.09 to 1.12) in North America (Pheterogeneity &amp;lt; .0001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Alcohol consumption was associated with UADT cancer risk, irrespective of smoking status or beverage type. However, due to differential baseline risks, alcohol is expected to impact the UADT cancer burden more in smokers than never smokers. These findings support public health strategies to reduce alcohol consumption.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jnci\/djaf230","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T11:53:17Z","timestamp":1755777197000},"page":"2598-2611","source":"Crossref","is-referenced-by-count":3,"title":["Alcohol consumption and upper aerodigestive tract squamous cell carcinoma: evidence from 28 prospective cohorts"],"prefix":"10.1093","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0910-3447","authenticated-orcid":false,"given":"Elmira","family":"Ebrahimi","sequence":"first","affiliation":[{"name":"Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC\/WHO) , Lyon,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1049-6225","authenticated-orcid":false,"given":"Sabine","family":"Naudin","sequence":"additional","affiliation":[{"name":"Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC\/WHO) , Lyon,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1678-9328","authenticated-orcid":false,"given":"Niki","family":"Dimou","sequence":"additional","affiliation":[{"name":"Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC\/WHO) , Lyon,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9635-0416","authenticated-orcid":false,"given":"Ana-Lucia","family":"May\u00e9n","sequence":"additional","affiliation":[{"name":"Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC\/WHO) , Lyon,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health , Boston, MA,","place":["United States"]},{"name":"Department of Biostatistics, Harvard T.H. Chan School of Public Health , Boston, MA,","place":["United States"]},{"name":"Channing Division of Network Medicine, Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3008-7843","authenticated-orcid":false,"given":"Christian C","family":"Abnet","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health , Rockville, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9594-4140","authenticated-orcid":false,"given":"Agneta","family":"\u00c5kesson","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine, Karolinska Institutet , Stockholm,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1028-1091","authenticated-orcid":false,"given":"Matthew J","family":"Barnett","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences, Fred Hutchinson Cancer Center , Seattle, WA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2538-0287","authenticated-orcid":false,"given":"Rino","family":"Bellocco","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet , Stockholm,","place":["Sweden"]},{"name":"Department of Statistics and Quantitative Methods, University of Milano-Bicocca , Milan,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7332-8387","authenticated-orcid":false,"given":"Amy","family":"Berrington de Gonzalez","sequence":"additional","affiliation":[{"name":"Division of Genetics and Epidemiology, Institute of Cancer Research , London, MD,","place":["United Kingdom"]},{"name":"Cancer Epidemiology and Prevention Research Unit, Institute of Cancer Research and Imperial College London , London,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2219-7970","authenticated-orcid":false,"given":"Stephanie E","family":"Bonn","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology, Department of Medicine (Solna), Karolinska Institutet , Stockholm,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2267-8050","authenticated-orcid":false,"given":"Chu","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences, Fred Hutchinson Cancer Center , Seattle, WA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0301-0242","authenticated-orcid":false,"given":"David C","family":"Christiani","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard T.H. 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