{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:25:43Z","timestamp":1787009143044,"version":"build-2736575974"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"American Society of Clinical Oncology Conquer Cancer"},{"name":"Novartis Oncology Endowed"},{"name":"Young Investigator Award in Health Disparities"},{"name":"St Baldrick\u2019s Scholar"},{"DOI":"10.13039\/100000054","name":"NCI","doi-asserted-by":"publisher","award":["K12CA076931-22"],"award-info":[{"award-number":["K12CA076931-22"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","award":["R01HL164925"],"award-info":[{"award-number":["R01HL164925"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","award":["R01HL163657"],"award-info":[{"award-number":["R01HL163657"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"name":"PCORI Methods","award":["ME-2021C3-24942"],"award-info":[{"award-number":["ME-2021C3-24942"]}]},{"name":"PCORI Methods","award":["R01HL163657"],"award-info":[{"award-number":["R01HL163657"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cytomolecular features critical for risk-stratified treatment determination in pediatric acute myeloid leukemia (AML) were expanded in Children\u2019s Oncology Group (COG) Phase III trial AAML1831 based on previous trials. It remains unknown whether the cytomolecular risk profiles are generalizable to the real-world. We addressed this knowledge gap using a nationally representative real-world cohort of 913 pediatric AML patients. Distributions of cytomolecular risk profiles and individual markers were comparable for trial-enrolled and non-enrolled patients, as well as across social drivers of trial enrollment (race\/ethnicity, language, insurance, acuity). Compared to patients with only favorable cytomolecular markers (4-year overall survival [OS] = 89.48%; 95% CI = 84.46% to 92.95%), patients with both favorable and unfavorable (hazards ratio [HR] = 2.49, 95% CI = 1.18 to 5.23), neutral (HR\u2009=\u20094.33, 95% CI = 2.75 to 6.82), and only unfavorable (HR\u2009=\u20095.80, 95% CI = 3.70 to 9.11) markers all had increased hazards of death. Cytomolecular risk informed by trial data appears to be generalizable to the real-world setting in pediatric AML.<\/jats:p>","DOI":"10.1093\/jnci\/djaf234","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T11:21:23Z","timestamp":1755516083000},"page":"746-750","source":"Crossref","is-referenced-by-count":1,"title":["Real-world generalizability of clinical trial cytomolecular risk in pediatric acute myeloid leukemia: a report from the REAL-AML cohort"],"prefix":"10.1093","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2217-088X","authenticated-orcid":false,"given":"Daniel J","family":"Zheng","sequence":"first","affiliation":[{"name":"Division of Oncology, Children\u2019s Hospital of Philadelphia , Philadelphia, PA,","place":["United 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Dana-Farber Cancer Institute , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2873-6058","authenticated-orcid":false,"given":"Emi H","family":"Caywood","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Thomas Jefferson University , Philadelphia, PA,","place":["United States"]},{"name":"Pediatric Hematology\/Oncology, Nemours Children\u2019s Health , Wilmington, DE,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7183-7826","authenticated-orcid":false,"given":"Anderson B","family":"Collier","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology, Nemours Children\u2019s Health , Jacksonville, FL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2474-3031","authenticated-orcid":false,"given":"Caitlin 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Philadelphia , Philadelphia, PA,","place":["United States"]},{"name":"Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1799-2582","authenticated-orcid":false,"given":"Alix E","family":"Seif","sequence":"additional","affiliation":[{"name":"Division of Oncology, Children\u2019s Hospital of Philadelphia , Philadelphia, PA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9154-6855","authenticated-orcid":false,"given":"Caroline","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Texas Southwestern Medical Center , Dallas, TX,","place":["United 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