{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T22:47:48Z","timestamp":1768344468999,"version":"3.49.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"1","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Evidence supports a modest positive association between alcohol intake and pancreatic ductal adenocarcinoma (PDAC); however, knowledge regarding mechanisms underlying the association is scarce. Investigation of lipidomic metabolites may provide mechanistic insights into this association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We measured 611 lipid species across 14 lipid classes in serum samples collected up to 24\u2009years before PDAC diagnosis in 2 nested case-control studies (706 matched sets) within American and Finnish cohorts. We conducted cross-sectional analyses using multivariable linear regressions to examine associations between log-transformed self-reported alcohol intake and log-transformed lipid concentrations among controls within each cohort. The identified alcohol-associated lipids in both cohorts were then evaluated for PDAC risk using multivariable conditional logistic regressions and fixed-effects meta-analyses to estimate overall odds ratios across the 2 cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Alcohol intake was associated with 21 lipid species, 11 class-specific fatty acids (FA), 3 total FA, and 1 lipid class at Bonferroni significance thresholds with similar directions of associations in both cohorts. Among them, total pentadecanoic acid (FA15:0) and 7 lipid species\u2014TAG(49:3-FA18:2), TAG(51:3-FA18:2), TAG(49:2-FA18:2), TAG(51:3-FA15:0), TAG(51:2-FA18:2), TAG(51:2-FA15:0), and PC(15:0\u201318:2)\u2014were inversely associated with alcohol intake and with PDAC risk at false discovery rate &amp;lt;0.10, with overall odds ratios ranging from 0.82 to 0.86, without evidence of heterogeneity by smoking habits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Findings from 2 prospective cohorts identified 7 lipid species and 1 FA inversely associated with both alcohol intake and PDAC risk. These results suggest that alcohol intake may be positively associated with PDAC through downregulation of circulating lipids years before PDAC diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jnci\/djaf288","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T13:29:23Z","timestamp":1760448563000},"page":"160-169","source":"Crossref","is-referenced-by-count":0,"title":["Lipid biomarkers of habitual alcohol intake and associations with pancreatic cancer risk"],"prefix":"10.1093","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3138-2330","authenticated-orcid":false,"given":"Paloma R","family":"Mitra","sequence":"first","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health , Rockville, MD,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9862-9434","authenticated-orcid":false,"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health , Rockville, MD,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4280-6243","authenticated-orcid":false,"given":"Hyokyoung G","family":"Hong","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health , Rockville, MD,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8330-4293","authenticated-orcid":false,"given":"Demetrius","family":"Albanes","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health , Rockville, MD,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3834-1535","authenticated-orcid":false,"given":"Stephanie J","family":"Weinstein","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health , Rockville, MD,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8169-1661","authenticated-orcid":false,"given":"Steven C","family":"Moore","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health , Rockville, MD,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3698-7006","authenticated-orcid":false,"given":"Rachael Z","family":"Stolzenberg-Solomon","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health , Rockville, MD,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1049-6225","authenticated-orcid":false,"given":"Sabine","family":"Naudin","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health , Rockville, MD,","place":["United States"]},{"name":"UPS, UVSQ, Inserm, Gustave Roussy, CESP , Villejuif 94800,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"2026011207523074100_djaf288-B1"},{"key":"2026011207523074100_djaf288-B2","author":"Ferlay","year":"2018"},{"key":"2026011207523074100_djaf288-B3","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"2026011207523074100_djaf288-B4","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1093\/ije\/dyx232","article-title":"Pancreatic cancer incidence trends: evidence from the Surveillance, Epidemiology and End Results (SEER) population-based data","volume":"47","author":"Gordon-Dseagu","year":"2018","journal-title":"Int J Epidemiol"},{"key":"2026011207523074100_djaf288-B5","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/s41575-021-00457-x","article-title":"Pancreatic cancer epidemiology: understanding the role of lifestyle and inherited risk factors","volume":"18","author":"Klein","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2026011207523074100_djaf288-B6","author":"WCRF\/AICR","year":"2018"},{"key":"2026011207523074100_djaf288-B7","first-page":"1","article-title":"Personal habits and indoor combustions. 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