{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:26:30Z","timestamp":1792794390512,"version":"4.5.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC1700603"],"award-info":[{"award-number":["2017YFC1700603"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Noncommunicable Chronic Diseases-National Science and Technology Major Project","award":["2024ZD0521302"],"award-info":[{"award-number":["2024ZD0521302"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Cancer Institute Cancer Center","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}]},{"name":"Translational and Integrative Medicine Research Fund at Memorial Sloan Kettering Cancer Center","id":[{"id":"https:\/\/ror.org\/02yrq0923","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with locally advanced gastric cancer who undergo curative intent gastrectomy experience a decline in health-related quality of life (HRQOL) during adjuvant chemotherapy. The Electro-Acupuncture in Gastric Cancer (EAGER) trial sought to evaluate the ability of electro-acupuncture to preserve HRQOL in these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this open-label, multicenter, parallel controlled trial, patients with stage II-III gastric cancer across 11 hospitals in China who were undergoing chemotherapy following gastrectomy were randomly assigned to receive high-frequency electro-acupuncture, low-frequency electro-acupuncture, or no electro-acupuncture during the first 3 cycles of chemotherapy. The Functional Assessment of Cancer Therapy-Gastric was reported by patients at baseline and once weekly during the therapy. The primary outcome was the difference among groups in the Functional Assessment of Cancer Therapy-Gastric Trial Outcome Index trajectory during the study duration by the standardized area under the curve.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 222 patients randomly assigned and analyzed, electro-acupuncture was associated with higher HRQOL measured by Trial Outcome Index\u2013area under the curve (mean \u00b1 SD = 5678\u2009\u00b1\u20091229 [high-frequency electro-acupuncture], 5558\u2009\u00b1\u20091226 [low-frequency electro-acupuncture], and 4735\u2009\u00b1\u20091233 [usual care]; P\u2009&amp;lt;\u2009.001). No difference was seen based on acupuncture dosing (P\u2009=\u2009.557). Participants in the electro-acupuncture groups also showed a statistically significant improvement in disease-free survival (high-frequency electro-acupuncture vs usual care: hazard ratio [HR]\u2009=\u20090.47, 95% confidence interval [CI] =0.24 to 0.93; P\u2009=\u2009.026; low-frequency electro-acupuncture vs usual care: HR\u2009=\u20090.51, 95% CI = 0.28 to 0.95; P\u2009=\u2009.030), fewer grade 3-4 adverse events (20.7% vs 39.0%, P\u2009=\u2009.004), and decreased peripheral myeloid-derived suppressor cells (P\u2009=\u2009.038) compared with the usual care group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Use of electro-acupuncture resulted in higher HRQOL in gastric cancer patients undergoing adjuvant chemotherapy, irrespective of dosing. Electro-acupuncture was also associated with prolonged disease-free survival and lower treatment-associated toxicities, which warrants further confirmative research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov NCT04360577.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jnci\/djaf309","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T12:00:37Z","timestamp":1761307237000},"page":"603-612","source":"Crossref","is-referenced-by-count":1,"title":["Electro-acupuncture for quality of life during adjuvant chemotherapy in gastric cancer: a randomized trial"],"prefix":"10.1093","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1956-7774","authenticated-orcid":false,"given":"Yan-Juan","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Oncology, Guangdong Provincial 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Traditional Chinese Medicine , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Gastrointestinal Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine , Guangzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Chang","family":"Diao","sequence":"additional","affiliation":[{"name":"Gastrointestinal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1799-4841","authenticated-orcid":false,"given":"Yong","family":"Li","sequence":"additional","affiliation":[{"name":"Gastrointestinal Surgery, Guangdong Provincial People\u2019s Hospital, Southern Medical University , Guangzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Fifth Affiliated Hospital of Sun Yat-sen University , Zhuhai,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Xiao","sequence":"additional","affiliation":[{"name":"Medical Oncology, Guangdong Provincial People\u2019s Hospital, Southern Medical University , Guangzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Hui","family":"Zhai","sequence":"additional","affiliation":[{"name":"Medical Oncology, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Long","family":"Yu","sequence":"additional","affiliation":[{"name":"Gastrointestinal Surgery, Zhujiang Hospital of Southern Medical University , Guangzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Foshan First People\u2019s Hospital , Foshan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Xu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine , Guangzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Liang","family":"Huang","sequence":"additional","affiliation":[{"name":"Gastrointestinal Surgery, Affiliated Cancer Hospital and Institute of Guangzhou Medical University , Guangzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Gastrointestinal Surgery, Yuebei People\u2019s Hospital , Shaoguan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwei","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Key Unit of Methodology in Clinical Research, Guangdong Provincial Hospital of Traditional Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine , Guangzhou,","place":["China"]},{"name":"Department of Global Public Health, Karolinska Institute , Stockholm,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yelena Y","family":"Janjigian","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, Memorial Sloan Kettering Cancer Center , New York, NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel L","family":"Cytryn","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, Memorial Sloan Kettering Cancer Center , New York, 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Guangzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7663-120X","authenticated-orcid":false,"given":"Hao-Chuan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Oncology, Guangdong Provincial Hospital of Traditional Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine , Guangzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7799-9356","authenticated-orcid":false,"given":"Ya-Dong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Oncology, Guangdong Provincial Hospital of Traditional Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine , Guangzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Jun","family":"Peng","sequence":"additional","affiliation":[{"name":"Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-sen University , Guangzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9229-0380","authenticated-orcid":false,"given":"Jun J","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Medicine, Memorial Sloan Kettering Cancer Center , New York, NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8104-4280","authenticated-orcid":false,"given":"Hai-Bo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Guangdong Provincial Hospital of Traditional Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine , 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