{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:27:45Z","timestamp":1791613665139,"version":"4.3.4"},"reference-count":20,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Foundation for Barnes-Jewish Hospital; the Siteman Cancer Center; the National Institutes of Health","award":["Grants R01 CA253475 and U01 CA265735"],"award-info":[{"award-number":["Grants R01 CA253475 and U01 CA265735"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Surveillance, Epidemiology, and End Results (SEER) multiple myeloma survival statistics (https:\/\/seer.cancer.gov\/statfacts\/html\/mulmy.html) that have been used to guide multiple myeloma management and control have been systematically overestimated because of the inclusion of smoldering multiple myeloma, a premalignant condition of multiple myeloma. Using the latest SEER release, we estimated the extent of such overestimation in the survival statistics. In 2016, 77.9% of 5495 patients reported as overall multiple myeloma were symptomatic multiple myeloma, and 10.9% were smoldering multiple myeloma. Median survival was 65.8\u2009months for overall multiple myeloma vs 56.8\u2009months for symptomatic multiple myeloma (P\u2009&amp;lt;\u2009.001). Inclusion of smoldering multiple myeloma overestimated multiple myeloma survival by 9\u2009months. Five-year relative survival estimates from 2015 to 2021 were 61.6% for overall multiple myeloma, 57.9% for symptomatic multiple myeloma, and 88.3% for smoldering multiple myeloma vs SEER\u2019s reported 62.4%. Survival statistics for symptomatic multiple myeloma and smoldering multiple myeloma should be reported separately to guide multiple myeloma management and prevention at the population level.<\/jats:p>","DOI":"10.1093\/jnci\/djag028","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T12:25:19Z","timestamp":1770035119000},"source":"Crossref","is-referenced-by-count":1,"title":["Overestimation of multiple myeloma survival from cancer registry data"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5245-5187","authenticated-orcid":false,"given":"John H","family":"Huber","sequence":"first","affiliation":[{"name":"Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine , St. Louis, MO,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3560-9460","authenticated-orcid":false,"given":"Mei","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine , St. Louis, MO,","place":["United States"]},{"name":"Research Service, St. Louis Veterans Affairs Medical Center , St. Louis, MO,","place":["United States"]},{"name":"Division of Biology and Biomedical Sciences, Washington University School of Medicine , St. Louis, MO,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2169-4174","authenticated-orcid":false,"given":"Rong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chronic Disease Epidemiology, Yale School of Public Health , New Haven, CT,","place":["United States"]},{"name":"Cancer Outcomes, Public Policy, and Effectiveness Research Center, Yale University , New Haven, CT,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6388-5553","authenticated-orcid":false,"given":"Martin W","family":"Schoen","sequence":"additional","affiliation":[{"name":"Research Service, St. Louis Veterans Affairs Medical Center , St. Louis, MO,","place":["United States"]},{"name":"Division of Hematology and Oncology, Saint Louis University School of Medicine , St. Louis, MO,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7307-0291","authenticated-orcid":false,"given":"Graham A","family":"Colditz","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine , St. Louis, MO,","place":["United 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