{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T04:51:39Z","timestamp":1781412699606,"version":"3.54.1"},"reference-count":24,"publisher":"Oxford University Press (OUP)","funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute at the National Institutes of Health","doi-asserted-by":"publisher","award":["U01-CA286811"],"award-info":[{"award-number":["U01-CA286811"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute at the National Institutes of Health","doi-asserted-by":"publisher","award":["U01-CA286821"],"award-info":[{"award-number":["U01-CA286821"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute at the National Institutes of Health","doi-asserted-by":"publisher","award":["U01-CA286810"],"award-info":[{"award-number":["U01-CA286810"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute at the National Institutes of Health","doi-asserted-by":"publisher","award":["U01-CA286808"],"award-info":[{"award-number":["U01-CA286808"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute at the National Institutes of Health","doi-asserted-by":"publisher","award":["U01-CA286813"],"award-info":[{"award-number":["U01-CA286813"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wake Forest NCORP Research Base","award":["UG1CA189824"],"award-info":[{"award-number":["UG1CA189824"]}]},{"name":"Alliance NCORP Research Base","award":["UG1CA189823"],"award-info":[{"award-number":["UG1CA189823"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cannabis use for symptom management among patients with cancer has increased in recent years, with many reporting benefits for pain, anxiety, sleep, nausea, and appetite, as well as other symptoms. However, rigorous prospective data on the potential benefits and harms of cannabis use in this population are lacking. This commentary describes a US National Cancer Institute\u2013led initiative addressing this research gap by supporting 5 prospective observational studies evaluating the benefits and harms of cannabis use among a large heterogeneous sample of patients with cancer undergoing active systemic treatment. We provide an overview of each study, including cancer type, treatment modalities, inclusion and exclusion criteria, data collection methods, and patient-reported and cancer-related outcomes.<\/jats:p>","DOI":"10.1093\/jnci\/djag057","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T12:39:06Z","timestamp":1771936746000},"source":"Crossref","is-referenced-by-count":1,"title":["Leveraging the National Cancer Institute\u2019s collaborative efforts to understand the benefits and harms of cannabis use among individuals with cancer"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3173-6590","authenticated-orcid":false,"given":"Shannon M","family":"Nugent","sequence":"first","affiliation":[{"name":"Knight Cancer Institute and Department of Psychiatry, Oregon Health and Science University, Portland, OR,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4664-009X","authenticated-orcid":false,"given":"Rebecca L","family":"Ashare","sequence":"additional","affiliation":[{"name":"Department of Psychology, State University of New York at Buffalo , Buffalo, NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Cullen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Houston Methodist Neal Cancer Center , Houston, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8563-3330","authenticated-orcid":false,"given":"Reina","family":"Haque","sequence":"additional","affiliation":[{"name":"Department of Research and Evaluation, and Bernard J. Tyson School of Medicine, Kaiser Permanente Southern California , Pasadena, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0021-5699","authenticated-orcid":false,"given":"Jennifer","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine , Miami, FL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard T","family":"Lee","sequence":"additional","affiliation":[{"name":"Departments of Supportive Care Medicine and Medical Oncology, City of Hope National Medical Center , Duarte, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5866-8279","authenticated-orcid":false,"given":"Salimah H","family":"Meghani","sequence":"additional","affiliation":[{"name":"Department of Biobehavioral Health Sciences, University of Pennsylvania , Philadelphia, PA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8087-6667","authenticated-orcid":false,"given":"Arnold L","family":"Potosky","sequence":"additional","affiliation":[{"name":"Cancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center , Washington, DC,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7318-9081","authenticated-orcid":false,"given":"Beth A","family":"Reboussin","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences, Wake Forest University School of Medicine , Winston-Salem, NC,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3859-8023","authenticated-orcid":false,"given":"Alfonso","family":"Romero-Sandoval","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences, Wake Forest University School of Medicine , Winston-Salem, NC,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5955-5148","authenticated-orcid":false,"given":"Kimberly G","family":"Wagoner","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences, Wake Forest University School of Medicine , Winston-Salem, NC,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7265-778X","authenticated-orcid":false,"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Florida , Gainesville, FL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6687-1760","authenticated-orcid":false,"given":"Brooke","family":"Worster","sequence":"additional","affiliation":[{"name":"Sydney Kimmel Cancer Center, Thomas Jefferson University , Philadelphia, PA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8523-9162","authenticated-orcid":false,"given":"Kelly K","family":"Filipski","sequence":"additional","affiliation":[{"name":"Clinical and Translational Epidemiology Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, MD, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew N","family":"Freedman","sequence":"additional","affiliation":[{"name":"Clinical and Translational Epidemiology Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, MD, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"2026042015134483500_djag057-B1","author":"Hartman","year":"2022"},{"key":"2026042015134483500_djag057-B2","doi-asserted-by":"publisher","first-page":"4040","DOI":"10.1002\/cncr.33794","article-title":"Cannabis use among cancer survivors in the United States: analysis of a nationally representative sample","volume":"127","author":"Do","year":"2021","journal-title":"Cancer"},{"key":"2026042015134483500_djag057-B3","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1089\/jpm.2019.0218","article-title":"Attitudes and beliefs about medical usefulness and legalization of marijuana among cancer patients in a legalized and a nonlegalized state","volume":"22","author":"Tanco","year":"2019","journal-title":"J Palliat Med"},{"key":"2026042015134483500_djag057-B4","doi-asserted-by":"publisher","first-page":"219","DOI":"10.3747\/co.25.3983","article-title":"Rates of cannabis use in patients with cancer","volume":"25","author":"Martell","year":"2018","journal-title":"Curr Oncol"},{"key":"2026042015134483500_djag057-B5","first-page":"85","article-title":"Cannabis use in palliative oncology: a review of the evidence for popular indications","volume":"19","author":"Turgeman","year":"2017","journal-title":"Isr Med Assoc J"},{"key":"2026042015134483500_djag057-B6","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1136\/bmjspcare-2019-002032","article-title":"Cannabinoids for adult cancer-related pain: systematic review and meta-analysis","volume":"10","author":"Boland","year":"2020","journal-title":"BMJ Support Palliat Care"},{"key":"2026042015134483500_djag057-B7","doi-asserted-by":"publisher","first-page":"n1034","DOI":"10.1136\/bmj.n1034","article-title":"Medical cannabis or cannabinoids for chronic non-cancer and cancer-related pain: a systematic review and meta-analysis of randomised clinical trials","volume":"374","author":"Wang","year":"2021","journal-title":"BMJ"},{"key":"2026042015134483500_djag057-B8","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1200\/jco.23.02596","article-title":"Cannabis and cannabinoids in adults with cancer: ASCO guideline","volume":"42","author":"Braun","year":"2024","journal-title":"J Clin Oncol"},{"key":"2026042015134483500_djag057-B9","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1093\/jncimonographs\/lgae007","article-title":"A survey of patients with cancer and oncology health-care professionals about cannabis use during treatment","volume":"2024","author":"Lee","year":"2024","journal-title":"J Natl Cancer Inst Monogr"},{"key":"2026042015134483500_djag057-B10","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/cncr.33202","article-title":"Cancer patients\u2019 experiences with medicinal cannabis-related care","volume":"127","author":"Braun","year":"2021","journal-title":"Cancer"},{"key":"2026042015134483500_djag057-B11","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1200\/jco.2017.76.1221","article-title":"Medical oncologists\u2019 beliefs, practices, and knowledge regarding marijuana used therapeutically: a nationally representative survey study","volume":"36","author":"Braun","year":"2018","journal-title":"J Clin Oncol"},{"key":"2026042015134483500_djag057-B12","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1634\/theoncologist.2018-0383","article-title":"Cannabis impacts tumor response rate to nivolumab in patients with advanced malignancies","volume":"24","author":"Taha","year":"2019","journal-title":"Oncologist"},{"key":"2026042015134483500_djag057-B13","doi-asserted-by":"publisher","first-page":"2447","DOI":"10.3390\/cancers12092447","article-title":"Cannabis consumption used by cancer patients during immunotherapy correlates with poor clinical outcome","volume":"12","author":"Bar-Sela","year":"2020","journal-title":"Cancers (Basel)"},{"key":"2026042015134483500_djag057-B14","author":"Biedny","year":"2020"},{"key":"2026042015134483500_djag057-B15","doi-asserted-by":"publisher","first-page":"974","DOI":"10.2174\/1570159X17666190603171901","article-title":"Cannabidiol adverse effects and toxicity","volume":"17","author":"Huestis","year":"2019","journal-title":"Curr Neuropharmacol"},{"key":"2026042015134483500_djag057-B16","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/s0959-8049(97)00340-7","article-title":"Pharmacokinetics of anticancer agents in patients with impaired liver function","volume":"34","author":"Donelli","year":"1998","journal-title":"Eur J Cancer"},{"key":"2026042015134483500_djag057-B17","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1054\/bjoc.2001.1784","article-title":"Combined paclitaxel and gemcitabine as first-line treatment in metastatic non-small cell lung cancer: a multicentre phase II study","volume":"84","author":"Douillard","year":"2001","journal-title":"Br J Cancer"},{"key":"2026042015134483500_djag057-B18","doi-asserted-by":"publisher","first-page":"3677","DOI":"10.1200\/JCO.2000.18.21.3677","article-title":"Phase I dose-finding and pharmacokinetic study of paclitaxel and carboplatin with oral valspodar in patients with advanced solid tumors","volume":"18","author":"Patnaik","year":"2000","journal-title":"J Clin Oncol"},{"key":"2026042015134483500_djag057-B19","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.ctrv.2016.02.001","article-title":"Management of toxicities of immune checkpoint inhibitors","volume":"44","author":"Spain","year":"2016","journal-title":"Cancer Treat Rev"},{"key":"2026042015134483500_djag057-B20","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1093\/jncimonographs\/lgae025","article-title":"Overview of cancer patient perspectives on cannabis use during treatment","volume":"2024","author":"Helzlsouer","year":"2024","journal-title":"J Natl Cancer Inst Monogr"},{"key":"2026042015134483500_djag057-B21","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1093\/jncimonographs\/lgae029","article-title":"Perceptions, prevalence, and patterns of cannabis use among cancer patients treated at 12 NCI-designated cancer centers","volume":"2024","author":"Ellison","year":"2024","journal-title":"J Natl Cancer Inst Monogr"},{"key":"2026042015134483500_djag057-B22","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1093\/jncimonographs\/lgad026","article-title":"Patient-provider communication about the use of medical cannabis for cancer symptoms: a cross-sectional study","volume":"2024","author":"Turner","year":"2024","journal-title":"J Natl Cancer Inst Monogr"},{"key":"2026042015134483500_djag057-B23","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1093\/jncimonographs\/lgab014","article-title":"The National Cancer Institute and cannabis and cannabinoids research","volume":"2021","author":"Ellison","year":"2021","journal-title":"J Natl Cancer Inst Monogr"},{"key":"2026042015134483500_djag057-B24","volume-title":"Cognitive Interviewing: A Tool for Improving Questionnaire Design","author":"Willis","year":"2004"}],"container-title":["JNCI: Journal of the National Cancer Institute"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jnci\/advance-article-pdf\/doi\/10.1093\/jnci\/djag057\/67136916\/djag057.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jnci\/advance-article-pdf\/doi\/10.1093\/jnci\/djag057\/67136916\/djag057.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T19:13:55Z","timestamp":1776712435000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnci\/advance-article\/doi\/10.1093\/jnci\/djag057\/8499662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,26]]},"references-count":24,"URL":"https:\/\/doi.org\/10.1093\/jnci\/djag057","relation":{},"ISSN":["0027-8874","1460-2105"],"issn-type":[{"value":"0027-8874","type":"print"},{"value":"1460-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,26]]},"article-number":"djag057"}}