{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:09:43Z","timestamp":1788826183104,"version":"build-2803163510"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004622","name":"Dutch Cancer Society","doi-asserted-by":"publisher","award":["12710"],"award-info":[{"award-number":["12710"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with Hodgkin lymphoma are at increased risk of developing lung cancer, especially after chest radiation therapy. No tools are currently available, however, to predict lung cancer risk for different Hodgkin lymphoma treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a cohort of 5370 individuals who had survived Hodgkin lymphoma for at least 5 years, were 15 to 50\u2009years of age at the time of Hodgkin lymphoma diagnosis, and who were treated in the Netherlands between 1965 and 2012, we used radiation therapy fields and prescribed dose to estimate mean lung dose. The twinning method was used to divide the cohort into homogenous parts: 80% for model development and 20% for validation using inverse probability of censoring weighting area under the curve. Cox proportional hazards models allowing for time-dependent coefficients were used to model time from Hodgkin lymphoma diagnosis to lung cancer and lung cancer\u2013free death as the competing event for predicting absolute lung cancer risk up to 30\u2009years after Hodgkin lymphoma diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Treatment information consisted of supradiaphragmatic radiation therapy in 75.2% of patients with a mean lung dose of 15.8 Gy. During follow-up, 218 survivors developed lung cancer. Older age, male sex, smoking at the time of Hodgkin lymphoma diagnosis, and higher mean lung dose were associated with higher lung cancer risk. The median Inter Quartile Range (IQR) estimated 30-year absolute lung cancer risk in our cohort was 1.2% (0.8%-1.9%) in nonsmokers and 6.9% (4.6%-10.9%) in smokers at the time of Hodgkin lymphoma diagnosis. The 20-year and 30-year inverse probability of censoring weighting areas under the curve values were 0.79 (95% Confidence Interval (CI)\u2009=\u20090.73 to 0.85) and 0.75 (95% CI\u2009=\u20090.69 to 0.81), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We developed a well-calibrated prediction tool that estimates long-term risk of lung cancer with good discrimination based on patient characteristics and mean lung dose, allowing application in Hodgkin lymphoma survivors and contemporary patients with Hodgkin lymphoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jnci\/djag090","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:44:31Z","timestamp":1773924271000},"page":"1610-1617","source":"Crossref","is-referenced-by-count":0,"title":["Predicting long-term absolute risk of lung cancer in patients with Hodgkin lymphoma"],"prefix":"10.1093","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7518-157X","authenticated-orcid":false,"given":"Shahin","family":"Roshani","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Netherlands Cancer Institute , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8535-8380","authenticated-orcid":false,"given":"Naomi B","family":"Boekel","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Netherlands Cancer Institute , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5871-1484","authenticated-orcid":false,"given":"Flora E","family":"Van Leeuwen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Netherlands Cancer Institute , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9590-9667","authenticated-orcid":false,"given":"Saskia E","family":"Rademakers","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Leiden University Medical Center , Leiden,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith M","family":"Roesink","sequence":"additional","affiliation":[{"name":"Department of Hematology, University Medical Center Utrecht , Utrecht,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maaike G A","family":"Schippers","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Instituut Verbeeten , Tilburg,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5095-4652","authenticated-orcid":false,"given":"Bastiaan D P","family":"Ta","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology (Maastro), GROW School for Oncology, Maastricht University Medical Centre , Maastricht,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9828-9460","authenticated-orcid":false,"given":"Wouter J","family":"Plattel","sequence":"additional","affiliation":[{"name":"Department of Hematology, University Medical Center Groningen, University of Groningen , Groningen,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1074-5922","authenticated-orcid":false,"given":"Jos\u00e9e M","family":"Zijlstra","sequence":"additional","affiliation":[{"name":"Department of Hematology, Amsterdam UMC, Location VUMC, Cancer Center Amsterdam , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic A X","family":"Schinagl","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Radboud University Medical Center , Nijmegen,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9069-4939","authenticated-orcid":false,"given":"Marten R","family":"Nijziel","sequence":"additional","affiliation":[{"name":"Department of Hemato-Oncology, Catharina Hospital , Eindhoven,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5793-6694","authenticated-orcid":false,"given":"Francisca","family":"Ong","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Medisch Spectrum Twente , Enschede,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik C","family":"Schimmel","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Radiotherapiegroep , Arnhem,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0882-2346","authenticated-orcid":false,"given":"Eduardus F M","family":"Posthuma","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Reinier de Graaf Hospital , Delft,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1977-2428","authenticated-orcid":false,"given":"Laurien A","family":"Daniels","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Amsterdam UMC, location AMC , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1146-9309","authenticated-orcid":false,"given":"Lara H","family":"B\u00f6hmer","sequence":"additional","affiliation":[{"name":"Department of Hematology, Haga Teaching Hospital , Den Haag,","place":["The 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