{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T22:45:32Z","timestamp":1794091532961,"version":"4.8.0"},"reference-count":79,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004802","name":"California Breast Cancer Research Program","doi-asserted-by":"publisher","award":["B28IB5461-S"],"award-info":[{"award-number":["B28IB5461-S"]}],"id":[{"id":"10.13039\/100004802","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UC Irvine Chao Comprehensive Cancer Center"},{"name":"National Cancer Institute of the National Institutes of Health","award":["P30CA062203"],"award-info":[{"award-number":["P30CA062203"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We conducted a randomized, double-blinded pilot trial to compare the impact of 2 electroacupuncture (EA) regimens on co-occurring neuropsychiatric symptoms among breast cancer survivors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Breast cancer survivors (BCS) who self-reported cognitive impairment, fatigue, insomnia, or psychological distress were randomized (1:1) to receive 10 weekly EA to target either neuropsychiatric-specific (neuropsychiatric-specific EA, nEA) or nonneuropsychiatric-specific (sham EA, sEA) acupoints. Primary endpoints were the within-group pre-post effect sizes (Glass\u2019s \u0394) in symptom severities, adjusted for multiple comparisons (Padjusted). Outcomes were assessed using neurocognitive tests (CANTAB), patient-reported outcomes (PROs) (Functional Assessment of Cancer Therapy-Cognitive Function, Multidimensional Fatigue Symptom Inventory-Short Form, European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30), plasma biomarkers, and neuroimaging. Responders were defined by reliable change index (for objective cognition) or minimal clinically important differences (for PROs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty-five participants were recruited, with 30 (86%) completing all sessions. The mean (\u00b1SD) age was 58.2 (\u00b112.2) years, and 86% reported co-occurring symptoms. Following treatment, the nEA group demonstrated significant improvements in attention (T3: \u0394\u2009=\u20090.562, T4: \u0394\u2009=\u20090.708, both Padjusted\u00a0&amp;lt;.05) and distress (T3: \u0394\u2009=\u20090.764, T4: \u0394\u2009=\u20090.711, both Padjusted\u2009&amp;lt;\u2009.05). More responders were observed after nEA treatment for objective cognition (42.9% vs 12.5%) and distress (50% vs 37.5%). Neuropsychiatric-specific EA-treated participants showed increased gray matter volume compared with sEA (P\u2009=\u2009.033), which positively correlated with better attention function (r\u2009=\u20090.69, P\u2009=\u2009.020). Neuropsychiatric-specific EA-related improvements in memory and response speed were associated with reduced connectivity in the default mode network (DMN-SFG, r\u2009=\u2009\u22120.93, P\u2009&amp;lt;\u2009.01) and increased connectivity in the dorsal attention network (DAN-SMG, r\u2009=\u20090.86, P\u2009&amp;lt;\u2009.001), respectively. All adverse events were grade 2 or lower.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion(s)<\/jats:title>\n                    <jats:p>Electroacupuncture targeting neuropsychiatric-specific acupoints suggests improvements in cognition and distress symptoms in BCS, warranting validation in larger, multicenter trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinicaltrials.gov<\/jats:title>\n                    <jats:p>NCT05283577.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jnci\/djag096","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T11:39:39Z","timestamp":1774957179000},"page":"1692-1704","source":"Crossref","is-referenced-by-count":4,"title":["Electroacupuncture improves cognitive function and neuropsychiatric symptoms in breast cancer survivors: a pilot randomized controlled trial"],"prefix":"10.1093","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0754-7901","authenticated-orcid":false,"given":"Ding Quan","family":"Ng","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, University of California , Irvine, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2831-5106","authenticated-orcid":false,"given":"Matthew","family":"Heshmatipour","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, University of California , Irvine, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3250-1876","authenticated-orcid":false,"given":"Julia","family":"Trudeau","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy 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