{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:38:38Z","timestamp":1790195918155,"version":"4.1.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004622","name":"Dutch Cancer Society","doi-asserted-by":"publisher","award":["KUN2014-7187"],"award-info":[{"award-number":["KUN2014-7187"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>BRCA1\/2 pathogenic variant (PV) carriers have an increased risk of tubo-ovarian cancer. They are recommended to have a risk-reducing salpingo-oophorectomy around age 40, resulting in premature menopause. The alternative risk-reducing salpingectomy (RRS) with delayed oophorectomy (DO) postpones this. We present the 5-year results of a nationwide preference trial (TUBA study) comparing menopause-related quality of life (QoL) after RRS\/DO with salpingo-oophorectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Premenopausal BRCA1\/2-PV carriers aged 25-40 (BRCA1) or 25-45 (BRCA2) chose RRS\/DO or salpingo-oophorectomy with or without hormonal replacement therapy (HRT). We compared QoL (Greene Climacteric Scale) between RRS\/DO and salpingo-oophorectomy without HRT 5 years after surgery using linear mixed models. Secondarily, RRS\/DO was compared with salpingo-oophorectomy with HRT. Women who underwent oophorectomy in the RRS\/DO group were excluded in a sensitivity analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 410 (71.9%) participants chose RRS\/DO and 160 (28.1%) salpingo-oophorectomy. Seventy-three (17.8%) participants underwent oophorectomy within 5 years after salpingectomy. The adjusted mean difference (aMD) in QoL was 1.8 (95% CI = \u22120.6 to 4.3) after salpingo-oophorectomy without HRT and 1.4 (95% CI = \u22120.4 to 3.1) after salpingo-oophorectomy with HRT compared with RRS (with and without oophorectomy) at 5 years follow-up. The sensitivity analysis showed that QoL decreased less after RRS before oophorectomy compared with salpingo-oophorectomy without (aMD = 2.4, 95% CI = 0.1 to 4.8) and with HRT (aMD = 1.9, 95% CI = 0.1 to 3.7).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Postponing oophorectomy is key in preventing deterioration of QoL. QoL was similar 5 years after salpingectomy (with and without oophorectomy) compared with salpingo-oophorectomy (regardless of HRT use). However, QoL was higher when comparing salpingectomy without oophorectomy to salpingo-oophorectomy (regardless of HRT use).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jnci\/djag110","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T11:46:36Z","timestamp":1775216796000},"page":"1731-1740","source":"Crossref","is-referenced-by-count":1,"title":["Menopause-related quality of life 5 years after salpingectomy with delayed oophorectomy vs salpingo-oophorectomy"],"prefix":"10.1093","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8916-1568","authenticated-orcid":false,"given":"Tamar A","family":"Gootzen","sequence":"first","affiliation":[{"name":"Department of Gynaecology and Obstetrics, Radboudumc , Nijmegen,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7624-7120","authenticated-orcid":false,"given":"Rosella P M 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Radboudumc , Nijmegen,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam J A","family":"Apperloo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Frisius MC , Leeuwarden,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique M A","family":"Brood-van Zanten","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Netherlands Cancer Institute\/Antoni van Leeuwenhoek , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6786-5824","authenticated-orcid":false,"given":"Sjors F P J","family":"Coppus","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maxima Medical Centre , Veldhoven,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose A 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