{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:28:48Z","timestamp":1791847728526,"version":"4.3.4"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"10","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"US Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ultraprocessed food (UPF) intake is associated with obesity. Despite obesity being a risk factor for postmenopausal breast cancer, evidence for an association between UPF and breast cancer is limited. Our objective was to assess the association between UPF intake and postmenopausal breast cancer risk in the NIH-AARP Diet and Health Study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants reported dietary intake via a food frequency questionnaire at baseline in 1995-1996 and were followed through 2018. Food items were disaggregated into food codes and assigned Nova classification via database linkage. Multivariable Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for quintiles of UPF (g\u00a0(1000\u2009kcal\u00a0day\u22121)\u22121) and postmenopausal breast cancer risk overall, by estrogen receptor (ER) status, and type (invasive or ductal carcinoma in situ [DCIS]), with and without adjustment for body mass index (BMI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 181\u00a0460 postmenopausal women, 14\u00a0484 were diagnosed with breast cancer over a median 21\u2009years of follow-up. Median (interquartile range) UPF intake was 284.6 (191.1-466.6)\u00a0g\u00a0(1000\u2009kcal\u00a0day\u22121)\u22121. No associations between UPF intake and postmenopausal breast cancer risk overall (HRQ5 vs Q1 = 0.98, 95% CI\u2009=\u20090.93 to 1.03; P = .32 for trend), by ER status (ER+: HRQ5 vs Q1 = 1.01, 95% CI\u2009=\u20090.94 to 1.09; P = .95 for trend; ER\u2212: HRQ5 vs Q1 = 1.02, 95% CI\u2009=\u20090.87 to 1.20; P = .58 for trend), or by type (invasive: HRQ5 vs Q1 = 0.98, 95% CI\u2009=\u20090.92 to 1.04; P = .14 for trend; DCIS HRQ5 vs Q1 = 1.00, 95% CI\u2009=\u20090.87 to 1.13; P = .26 for trend) were observed. Following BMI adjustment, inverse trends for overall (P = .03 for trend) and invasive (P = .01 for trend) breast cancer were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion(s)<\/jats:title>\n                    <jats:p>UPF intake was not associated with postmenopausal breast cancer in the NIH-AARP cohort. Inverse trends observed after adjusting for BMI are likely spurious, owing to overadjustment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jnci\/djag124","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T12:49:02Z","timestamp":1776430142000},"page":"1866-1873","source":"Crossref","is-referenced-by-count":3,"title":["Ultraprocessed food intake and postmenopausal breast cancer risk in the NIH-AARP Diet and Health Study"],"prefix":"10.1093","volume":"118","author":[{"given":"Caitlin P","family":"O\u2019Connell","sequence":"first","affiliation":[{"name":"Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health , Rockville, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2544-1067","authenticated-orcid":false,"given":"Kaelyn 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M","family":"Liao","sequence":"additional","affiliation":[{"name":"Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health , Rockville, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica M","family":"Madrigal","sequence":"additional","affiliation":[{"name":"Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health , Rockville, MD,","place":["United States"]},{"name":"School of Integrated Sciences, Sustainability, and Public Health, University of Illinois Springfield , Springfield, IL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camella J","family":"Rising","sequence":"additional","affiliation":[{"name":"Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health , Rockville, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2466-7462","authenticated-orcid":false,"given":"Rashmi","family":"Sinha","sequence":"additional","affiliation":[{"name":"Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health , Rockville, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Khandpur","sequence":"additional","affiliation":[{"name":"Division of Human Nutrition and Health, Wageningen University , Wageningen,","place":["Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2907-3153","authenticated-orcid":false,"given":"Eur\u00eddice","family":"Mart\u00ednez Steele","sequence":"additional","affiliation":[{"name":"NUPENS, School of Public Health, University of S\u00e3o Paulo , 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