{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T08:49:07Z","timestamp":1791535747674,"version":"4.3.4"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Increases in colorectal cancer (CRC) incidence among young adults were reported in 27 countries and territories worldwide, yet information on mortality trends is limited. Using the World Health Organization Mortality database (1990-2023), we found CRC mortality rates among younger adults (aged 25-49\u2009years) increased in 18 of 49 countries (0.7%-4.3% per year) during the most recent decade, decreased in 15, and were otherwise stable. Trends ranged from decreases of more than 2% per year in Singapore, Belgium, and Denmark to increases of more than 3% per year in Paraguay, Uruguay, Chile, and the United Kingdom. In half of the countries with increasing trends, rates in older adults (aged 50-79\u2009years) were stable (Colombia, Philippines, Croatia [women only]) or decreasing (Uruguay, the United Kingdom, Australia, Canada, the United States, Argentina). In the remainder\u2014primarily in Latin America and the Caribbean\u2014mortality rose in both groups. Increasing CRC mortality among younger adults may signal a growing future burden, reinforcing the need for etiologic investigation and heightened awareness to avert deaths through earlier detection.<\/jats:p>","DOI":"10.1093\/jnci\/djag153","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T16:35:30Z","timestamp":1781627730000},"page":"1975-1979","source":"Crossref","is-referenced-by-count":1,"title":["Trends in colorectal cancer mortality among younger vs older adults in 49 countries"],"prefix":"10.1093","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8021-5997","authenticated-orcid":false,"given":"Hyuna","family":"Sung","sequence":"first","affiliation":[{"name":"Surveillance, Prevention, and Health Services Research, American Cancer Society , Atlanta, GA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kieran","family":"Kelly","sequence":"additional","affiliation":[{"name":"Surveillance, Prevention, and Health Services Research, American Cancer Society , Atlanta, GA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9457-0950","authenticated-orcid":false,"given":"Chenxi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Surveillance, Prevention, and Health Services Research, American Cancer Society , Atlanta, GA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1568-7218","authenticated-orcid":false,"given":"Mathieu","family":"Laversanne","sequence":"additional","affiliation":[{"name":"Cancer Surveillance Branch, International Agency for Research on Cancer , Lyon,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L","family":"Siegel","sequence":"additional","affiliation":[{"name":"Surveillance, Prevention, and Health Services Research, American Cancer Society , Atlanta, GA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3248-7787","authenticated-orcid":false,"given":"Freddie","family":"Bray","sequence":"additional","affiliation":[{"name":"Cancer Surveillance Branch, International Agency for Research on Cancer , Lyon,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0000-4111","authenticated-orcid":false,"given":"Ahmedin","family":"Jemal","sequence":"additional","affiliation":[{"name":"Surveillance, Prevention, and Health Services Research, American Cancer Society , Atlanta, GA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"2026100903520519600_djag153-B1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"2026100903520519600_djag153-B2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S2468-1253(22)00003-6","article-title":"Addressing the rise of early-onset colorectal cancer","volume":"7","author":"The Lancet Gastroenterology Hepatology","year":"2022","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"2026100903520519600_djag153-B3","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S1470-2045(24)00600-4","article-title":"Colorectal cancer incidence trends in younger versus older adults: an analysis of population-based cancer registry data","volume":"26","author":"Sung","year":"2025","journal-title":"Lancet Oncol"},{"key":"2026100903520519600_djag153-B4","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/S2468-1253(19)30147-5","article-title":"Changes in colorectal cancer incidence in seven high-income countries: a population-based study","volume":"4","author":"Araghi","year":"2019","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"2026100903520519600_djag153-B5","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1136\/gutjnl-2019-319511","article-title":"Global patterns and trends in colorectal cancer incidence in young adults","volume":"68","author":"Siegel","year":"2019","journal-title":"Gut"},{"key":"2026100903520519600_djag153-B6","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1001\/jama.2025.25467","article-title":"Leading cancer deaths in people younger than 50 years","volume":"335","author":"Siegel","year":"2026","journal-title":"JAMA"},{"key":"2026100903520519600_djag153-B7","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1093\/jnci\/djae288","article-title":"Trends in cancer mortality under age 50 in 15 upper-middle and high-income countries","volume":"117","author":"Santucci","year":"2025","journal-title":"J Natl Cancer Inst"},{"key":"2026100903520519600_djag153-B8","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1038\/s41574-025-01159-z","article-title":"Early-onset colorectal cancer as an emerging disease of metabolic dysregulation","volume":"21","author":"Du","year":"2025","journal-title":"Nat Rev Endocrinol"},{"key":"2026100903520519600_djag153-B9","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/s41575-023-00841-9","article-title":"Changing epidemiology of colorectal cancer - birth cohort effects and emerging risk factors","volume":"21","author":"Murphy","year":"2024","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2026100903520519600_djag153-B10","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/s41586-024-07182-w","article-title":"A distinct Fusobacterium nucleatum clade dominates the colorectal cancer niche","volume":"628","author":"Zepeda-Rivera","year":"2024","journal-title":"Nature"},{"key":"2026100903520519600_djag153-B11","doi-asserted-by":"publisher","first-page":"2992","DOI":"10.1002\/ijc.32055","article-title":"Global trends in colorectal cancer mortality: projections to the year 2035","volume":"144","author":"Araghi","year":"2019","journal-title":"Int J Cancer"},{"key":"2026100903520519600_djag153-B12","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1186\/s12885-021-08809-1","article-title":"The implementation of colorectal cancer screening interventions in low-and middle-income countries: a scoping review","volume":"21","author":"Schliemann","year":"2021","journal-title":"BMC Cancer"},{"key":"2026100903520519600_djag153-B13","doi-asserted-by":"publisher","first-page":"S74","DOI":"10.1016\/j.canep.2016.03.010","article-title":"Burden of colorectal cancer in Central and South America","volume":"44(Suppl 1)","author":"Sierra","year":"2016","journal-title":"Cancer Epidemiol"},{"key":"2026100903520519600_djag153-B14","author":"Pan American Health Organization"},{"key":"2026100903520519600_djag153-B15","volume-title":"Cancer Screening in Five Continents"},{"key":"2026100903520519600_djag153-B16","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1002\/cncr.24760","article-title":"Annual report to the nation on the status of cancer, 1975-2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates","volume":"116","author":"Edwards","year":"2010","journal-title":"Cancer"},{"key":"2026100903520519600_djag153-B17","volume-title":"Tobacco or Health: A Global Status Report","author":"World Health Organization","year":"1997"},{"key":"2026100903520519600_djag153-B18","volume-title":"The Global Health Observatory","author":"World Health Organization","year":"2023"},{"key":"2026100903520519600_djag153-B19","doi-asserted-by":"publisher","first-page":"100136","DOI":"10.1016\/j.esmogo.2025.100136","article-title":"Re-evaluating population-level screening recommendations to address increasing early-onset colorectal cancer rates in Australia: a modelling study","volume":"7","author":"Lew","year":"2025","journal-title":"ESMO Gastrointest Oncol"},{"key":"2026100903520519600_djag153-B20","doi-asserted-by":"publisher","first-page":"2964","DOI":"10.1002\/cncr.31543","article-title":"The impact of the rising colorectal cancer incidence in young adults on the optimal age to start screening: microsimulation analysis I to inform the American Cancer Society colorectal cancer screening guideline","volume":"124","author":"Peterse","year":"2018","journal-title":"Cancer"},{"key":"2026100903520519600_djag153-B21","doi-asserted-by":"publisher","first-page":"e2413157","DOI":"10.1001\/jamanetworkopen.2024.13157","article-title":"Red flag signs and symptoms for patients with early-onset colorectal cancer: a systematic review and meta-analysis","volume":"7","author":"Demb","year":"2024","journal-title":"JAMA Netw Open"}],"container-title":["JNCI: Journal of the National Cancer Institute"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jnci\/advance-article-pdf\/doi\/10.1093\/jnci\/djag153\/68576483\/djag153.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jnci\/article-pdf\/118\/10\/1975\/68576483\/djag153.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jnci\/article-pdf\/118\/10\/1975\/68576483\/djag153.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:52:14Z","timestamp":1791532334000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnci\/article\/118\/10\/1975\/8713304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,16]]},"references-count":21,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,6,16]]},"published-print":{"date-parts":[[2026,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jnci\/djag153","relation":{},"ISSN":["0027-8874","1460-2105"],"issn-type":[{"value":"0027-8874","type":"print"},{"value":"1460-2105","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,10]]},"published":{"date-parts":[[2026,6,16]]}}}