{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:49:26Z","timestamp":1792511366205,"version":"4.5.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"the Sue and Radcliffe Killam endowment (G.J.C.) and the My Oncology Dream Award from the Japan Cancer Society"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The tumor, node, metastasis (TNM) classification at pathological evaluation determines prognosis following cancer treatment. For rectal cancer patients undergoing neoadjuvant therapy, whether ypTNM likely confers different prognosis than pTNM. We compared survival outcomes of patients classified by ypTNM vs pTNM staging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with resected locoregional rectal cancer from the National Cancer Database who underwent upfront surgery (pTNM) and had \u22655\u2009years follow-up (2010-2017) were compared with those receiving neoadjuvant therapy followed by surgery (ypTNM). To address treatment selection bias, analyses were stratified by receipt of guideline-concordant care. Overall survival (OS) was compared using Kaplan-Meier and multivariable Cox regression analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 50\u2009436 patients (median age = 60; 61.4% male), 11\u2009732 (23.3%) underwent upfront surgery and 38\u2009704 (76.7%) received neoadjuvant therapy; 78.8% of the upfront surgery group received guideline-concordant care. In analyses stratified by guideline-concordant care, overall survival was similar for stage 0-I (hazard ratio [HR] = 1.05; 95% CI = 0.96 to 1.15) but significantly worse for ypTNM vs pTNM in stage II (HR = 1.50; 95% CI = 1.27 to 1.77; 5-year OS = 75.6% vs 83.2%) and stage III (HR = 1.60; 95% CI = 1.46 to 1.75; 5-year OS = 67.0% vs 78.2%). Multivariable analysis confirmed ypTNM was associated with worse survival at each stage (stage 0-I: HR = 1.14, P = .004; stage II: HR = 1.49, P &amp;lt; .001; stage III: HR = 1.60, P &amp;lt; .001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Stage for stage, ypTNM classification is associated with worse survival than pTNM classification, with increasing difference at higher stages. Future staging systems and management guidelines should account for these differences to optimize prognostication and stratification for clinical trials and surveillance strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jnci\/djag192","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T12:39:32Z","timestamp":1781613572000},"source":"Crossref","is-referenced-by-count":1,"title":["ypTNM versus pTNM staging after neoadjuvant therapy in rectal cancer"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7481-9559","authenticated-orcid":false,"given":"Teppei","family":"Miyakawa","sequence":"first","affiliation":[{"name":"Department of Colon and Rectal Surgery, The University of Texas MD Anderson Cancer Center , Houston, TX,","place":["United States"]},{"name":"Department of Minimally Invasive Surgical and Medical Oncology, Fukushima Medical University , Fukushima,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7374-5730","authenticated-orcid":false,"given":"Jessica J","family":"Lie","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center , Houston, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1246-6348","authenticated-orcid":false,"given":"Chung-Yuan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Colon and Rectal Surgery, The University of Texas MD Anderson Cancer Center , Houston, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9682-4500","authenticated-orcid":false,"given":"Kentaro","family":"Ochiai","sequence":"additional","affiliation":[{"name":"Department of Colon and Rectal Surgery, The University of 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