{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T18:31:35Z","timestamp":1785868295800,"version":"3.56.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Brigham and Women\u2019s Department of Surgery Hale Family Research Fellowship"},{"DOI":"10.13039\/100000048","name":"the American Cancer Society","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Rob and Karen Hale Fund"},{"DOI":"10.13039\/100000050","name":"the National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"US Department of Health and Human Services","doi-asserted-by":"publisher","award":["75N92021D00001"],"award-info":[{"award-number":["75N92021D00001"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"US Department of Health and Human Services","doi-asserted-by":"publisher","award":["75N92021D00002"],"award-info":[{"award-number":["75N92021D00002"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"US Department of Health and Human Services","doi-asserted-by":"publisher","award":["75N92021D00003"],"award-info":[{"award-number":["75N92021D00003"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"US Department of Health and Human Services","doi-asserted-by":"publisher","award":["75N92021D00004"],"award-info":[{"award-number":["75N92021D00004"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"US Department of Health and Human Services","doi-asserted-by":"publisher","award":["75N92021D00005"],"award-info":[{"award-number":["75N92021D00005"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Breast cancer treatment can worsen frailty, but the impact of this decline on long-term quality of life remains uncertain. We identified women 65\u2009years of age and older with nonmetastatic breast cancer from the Life and Longevity After Cancer survivorship cohort of the Women\u2019s Health Initiative. We examined the association between clinically significant worsening of frailty, measured by a validated claims-based index 1 year after diagnosis, and long-term decline in quality of life, assessed using a 10-point scale 4-6\u2009years after diagnosis. Among 1061 eligible patients, 692 (65.2%) were robust (not living with frailty), 343 (32.3%) were living with prefrailty, and 26 (2.5%) were living with frailty at cancer diagnosis. Clinically significant worsening of frailty occurred in 19.5% of patients. In fully adjusted models, worsening frailty was statistically significantly associated with long-term quality of life declines (odds ratio\u2009=\u20091.48, 95% CI\u2009=\u20091.07 to 2.04). These findings highlight the need for interventions to prevent worsening frailty during breast cancer treatment.<\/jats:p>","DOI":"10.1093\/jnci\/djag218","type":"journal-article","created":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T20:03:03Z","timestamp":1783281783000},"source":"Crossref","is-referenced-by-count":0,"title":["Worsening frailty and declining quality of life in older survivors of nonmetastatic breast cancer"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9555-9487","authenticated-orcid":false,"given":"Christina A","family":"Minami","sequence":"first","affiliation":[{"name":"Department of Surgery, Brigham and Women\u2019s Hospital , Boston, MA,","place":["United States"]},{"name":"Center for Surgery and Public Health, Brigham and Women\u2019s Hospital , Boston, MA,","place":["United States"]},{"name":"Breast Oncology Center, Dana-Farber Cancer Institute , Boston, MA,","place":["United States"]},{"name":"Harvard Medical School , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah R","family":"Jager","sequence":"additional","affiliation":[{"name":"Public Health Sciences Division, Fred Hutchinson Cancer Center , Seattle, WA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliza H","family":"Lorentzen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Brigham and Women\u2019s Hospital , Boston, MA,","place":["United States"]},{"name":"Center for Surgery and Public Health, Brigham and Women\u2019s Hospital , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aladdin H","family":"Shadyab","sequence":"additional","affiliation":[{"name":"Herbert Wertheim School of Public Health and Human Longevity Science and Division of Geriatrics, Gerontology & Palliative Care, Department of Medicine, University of California San Diego , La Jolla, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L","family":"Krok-Schoen","sequence":"additional","affiliation":[{"name":"Division of Health Sciences, School of Health and Rehabilitation Sciences, College of Medicine, The Ohio State University , Columbus, OH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abu Taiyab","family":"Nazmus Saquib","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Medicine, Sulaiman Al Rajhi University , Al Bukayriah,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer J","family":"King","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, College of Health, Education and Social Transformation, New Mexico State University , Las Cruces, NM,","place":["United States"]},{"name":"Department of Health Promotion Science, Mel & Enid Zuckerman College of Public Health, University of Arizona , Tucson, AZ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5087-7837","authenticated-orcid":false,"given":"Garnet L","family":"Anderson","sequence":"additional","affiliation":[{"name":"Public Health Sciences Division, Fred Hutchinson Cancer Center , Seattle, WA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3602-2351","authenticated-orcid":false,"given":"Tari A","family":"King","sequence":"additional","affiliation":[{"name":"Department of Surgery, Emory School of Medicine , Atlanta, GA,","place":["United States"]},{"name":"Winship Cancer Institute of Emory University , Atlanta, GA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A","family":"Mittendorf","sequence":"additional","affiliation":[{"name":"Breast Oncology Center, Dana-Farber Cancer Institute , Boston, MA,","place":["United States"]},{"name":"Harvard Medical School , Boston, MA,","place":["United States"]},{"name":"Department of Surgery, Beth Israel Deaconess Medical Center , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"2026080413411429900_djag218-B1","author":"Cancer Stat Facts: Female Breast Cancer","year":"2025"},{"key":"2026080413411429900_djag218-B2","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3322\/caac.21871","article-title":"Cancer statistics, 2025","volume":"75","author":"Siegel","year":"2025","journal-title":"CA Cancer J Clin"},{"key":"2026080413411429900_djag218-B3","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/s0140-6736(12)62167-9","article-title":"Frailty in elderly 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