{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T08:23:07Z","timestamp":1794298987468,"version":"4.9.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Zhejiang Key Laboratory of Intelligent Preventive Medicine","award":["2025C02104"],"award-info":[{"award-number":["2025C02104"]}]},{"name":"Zhejiang Key Laboratory of Intelligent Preventive Medicine","award":["2026C02A1147"],"award-info":[{"award-number":["2026C02A1147"]}]},{"name":"Zhejiang Key Laboratory of Intelligent Preventive Medicine","award":["2026C02A1144"],"award-info":[{"award-number":["2026C02A1144"]}]},{"name":"Zhejiang Key Laboratory of Intelligent Preventive Medicine","award":["2020E10004"],"award-info":[{"award-number":["2020E10004"]}]},{"name":"Key Laboratory of Geriatric Long-term Care"},{"DOI":"10.13039\/100009122","name":"Ministry of Education","doi-asserted-by":"publisher","award":["LNYB-2025-04"],"award-info":[{"award-number":["LNYB-2025-04"]}],"id":[{"id":"10.13039\/100009122","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical and Health Science Program of Zhejiang Province","award":["2025HY0477"],"award-info":[{"award-number":["2025HY0477"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Clonal hematopoiesis of indeterminate potential (CHIP) and biological aging have been individually associated with increased cancer risks. However, their joint effect on cancer risks remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed data from 332\u00a0911 participants at baseline in the UK Biobank. We defined CHIP as a pathogenic variant with variant allele fractions \u22652%. Biological aging was assessed by the phenotypic age acceleration (PhenoAgeAccel) and categorized as biologically younger and older. Associations of CHIP and biological aging with 25 cancers were assessed by Cox proportional hazard models. Interactions between CHIP and biological aging were tested on additive and multiplicative scales.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CHIP was associated with higher risks of myeloid malignancies (HR = 9.56, 95% CI = 8.28 to 11.03), lung cancer (HR = 1.61, 95% CI = 1.42 to 1.82) and esophageal cancer (HR = 1.54, 95% CI = 1.18 to 2.01). Biologically older participants had higher risks of hematologic neoplasms (HR = 1.42, 95% CI = 1.30 to 1.55) and various solid tumors compared with biologically younger participants. CHIP carriers who were biologically older had increased risks of hematologic neoplasms (HR = 6.56, 95% CI = 5.67 to 7.59) and various solid tumors compared with biologically younger participants without CHIP. The proportion of excess risk attributable to additive interaction was 40% for hematologic neoplasms and 27% for lung cancer. A significant multiplicative interaction was also observed for hematologic neoplasms (Pinteraction &amp;lt; .001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CHIP confers substantial cancer risk, amplified when participants are biologically older. Assessing CHIP and biological aging may serve as an effective strategy for early screening and risk stratification for hematologic neoplasms and lung cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jnci\/djag268","type":"journal-article","created":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T12:01:29Z","timestamp":1785585689000},"page":"2159-2169","source":"Crossref","is-referenced-by-count":3,"title":["The joint association of clonal hematopoiesis of indeterminate potential and biological aging with cancer risk among 332\u00a0911 individuals"],"prefix":"10.1093","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3495-6786","authenticated-orcid":false,"given":"Li","family":"Wang","sequence":"first","affiliation":[{"name":"Affiliated Mental Health Centre & Hangzhou Seventh People\u2019s Hospital, Zhejiang University School of Medicine , Hangzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaili","family":"Sun","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou, Zhejiang,","place":["China"]},{"name":"Department of Big Data in Health Science, School of Public Health, Zhejiang University School of Medicine, Zhejiang Key Laboratory of Intelligent Preventive Medicine , Hangzhou, Zhejiang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Big Data in Health Science, School of Public Health, Zhejiang University School of Medicine, Zhejiang Key Laboratory of Intelligent Preventive Medicine , Hangzhou, Zhejiang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Big Data in Health Science, School of Public Health, Zhejiang University School of Medicine, Zhejiang Key Laboratory of Intelligent Preventive Medicine , Hangzhou, Zhejiang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqing","family":"Jia","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou, Zhejiang,","place":["China"]},{"name":"Department of Big Data in Health Science, School of Public Health, Zhejiang University School of Medicine, Zhejiang Key Laboratory of Intelligent Preventive Medicine , Hangzhou, Zhejiang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjie","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou, Zhejiang,","place":["China"]},{"name":"Department of Big Data in Health Science, School of Public Health, Zhejiang University School of Medicine, Zhejiang Key Laboratory of Intelligent Preventive Medicine , Hangzhou, Zhejiang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lujia","family":"Shen","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou, Zhejiang,","place":["China"]},{"name":"Department of Big Data in Health Science, School of Public Health, Zhejiang University School of Medicine, Zhejiang Key Laboratory of Intelligent Preventive Medicine , Hangzhou, Zhejiang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health, Hangzhou Medical College , Hangzhou, Zhejiang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Nursing, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University , Zhejiang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3992-5812","authenticated-orcid":false,"given":"Xiao","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Big Data in Health Science, School of Public Health, Zhejiang University School of Medicine, Zhejiang Key Laboratory of Intelligent Preventive Medicine , Hangzhou, Zhejiang,","place":["China"]},{"name":"Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , Hangzhou,","place":["China"]},{"name":"Department of Medical Sciences, Uppsala University , Uppsala,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2999-3689","authenticated-orcid":false,"given":"Jie","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou, Zhejiang,","place":["China"]},{"name":"Zhejiang Key Laboratory for Precision Diagnosis and Treatment of Hematological Malignancies , Hangzhou, Zhejiang,","place":["China"]},{"name":"Zhejiang Provincial Clinical Research Center for Hematological Disorders , Hangzhou, Zhejiang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6120-5913","authenticated-orcid":false,"given":"Zuyun","family":"Liu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou, Zhejiang,","place":["China"]},{"name":"Department of Big Data in Health Science, School of Public Health, Zhejiang University School of Medicine, Zhejiang Key Laboratory of Intelligent Preventive Medicine , Hangzhou, Zhejiang,","place":["China"]},{"name":"Center for Aging & Health Studies , Zhejiang University, Hangzhou, 310058, Zhejiang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"2026111002520284200_djag268-B1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"2026111002520284200_djag268-B2","first-page":"7","article-title":"Cancer statistics, 2018","volume":"68","author":"Siegel","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"2026111002520284200_djag268-B3","author":"Gerland","year":"2022"},{"key":"2026111002520284200_djag268-B4","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1182\/blood-2015-03-631747","article-title":"Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes","volume":"126","author":"Steensma","year":"2015","journal-title":"Blood"},{"key":"2026111002520284200_djag268-B5","doi-asserted-by":"publisher","first-page":"2477","DOI":"10.1056\/NEJMoa1409405","article-title":"Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence","volume":"371","author":"Genovese","year":"2014","journal-title":"N Engl J Med"},{"key":"2026111002520284200_djag268-B6","doi-asserted-by":"publisher","first-page":"2488","DOI":"10.1056\/NEJMoa1408617","article-title":"Age-related clonal hematopoiesis associated with adverse outcomes","volume":"371","author":"Jaiswal","year":"2014","journal-title":"N Engl J Med"},{"key":"2026111002520284200_djag268-B7","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1016\/j.celrep.2015.02.005","article-title":"Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis","volume":"10","author":"McKerrell","year":"2015","journal-title":"Cell Rep"},{"key":"2026111002520284200_djag268-B8","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1038\/nm.3733","article-title":"Age-related mutations associated with clonal hematopoietic expansion and malignancies","volume":"20","author":"Xie","year":"2014","journal-title":"Nat Med"},{"key":"2026111002520284200_djag268-B9","doi-asserted-by":"publisher","first-page":"5949","DOI":"10.1182\/bloodadvances.2024013414","article-title":"Myeloid clonal hematopoiesis of indeterminate potential in patients with chronic lymphocytic leukemia","volume":"8","author":"Vijenthira","year":"2024","journal-title":"Blood Adv"},{"key":"2026111002520284200_djag268-B10","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1158\/1078-0432.CCR-22-2598","article-title":"CHIP happens: clonal hematopoiesis of indeterminate potential and its relationship to solid tumors","volume":"29","author":"Reed","year":"2023","journal-title":"Clin Cancer Res"},{"key":"2026111002520284200_djag268-B11","doi-asserted-by":"publisher","first-page":"573","DOI":"10.18632\/aging.101414","article-title":"An epigenetic biomarker of aging for lifespan and healthspan","volume":"10","author":"Levine","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"2026111002520284200_djag268-B12","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1111\/jgs.18611","article-title":"Accelerated aging mediates the associations of unhealthy lifestyles with cardiovascular disease, cancer, and mortality","volume":"72","author":"Li","year":"2024","journal-title":"J Am Geriatr Soc"},{"key":"2026111002520284200_djag268-B13","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/s41586-018-0579-z","article-title":"The UK Biobank resource with deep phenotyping and genomic data","volume":"562","author":"Bycroft","year":"2018","journal-title":"Nature"},{"key":"2026111002520284200_djag268-B14","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1038\/s41588-022-01121-z","article-title":"Genome-wide analyses of 200,453 participants yield new insights into the causes and consequences of clonal hematopoiesis","volume":"54","author":"Kar","year":"2022","journal-title":"Nat Genet"},{"key":"2026111002520284200_djag268-B15","doi-asserted-by":"publisher","first-page":"2214","DOI":"10.1182\/blood.2022018825","article-title":"A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic data sets","volume":"141","author":"Vlasschaert","year":"2023","journal-title":"Blood"},{"key":"2026111002520284200_djag268-B16","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1038\/s41586-021-04103-z","article-title":"Exome sequencing and analysis of 454,787 UK Biobank participants","volume":"599","author":"Backman","year":"2021","journal-title":"Nature"},{"key":"2026111002520284200_djag268-B17","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/nbt.2514","article-title":"Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples","volume":"31","author":"Cibulskis","year":"2013","journal-title":"Nat Biotechnol"},{"key":"2026111002520284200_djag268-B18","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1038\/s41375-022-01613-1","article-title":"The 5th Edition of the World Health Organization Classification of Haematolymphoid Tumours: myeloid and histiocytic\/dendritic neoplasms","volume":"36","author":"Khoury","year":"2022","journal-title":"Leukemia"},{"key":"2026111002520284200_djag268-B19","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1093\/eurheartj\/ehad670","article-title":"Clonal haematopoiesis of indeterminate potential predicts incident cardiac arrhythmias","volume":"45","author":"Schuermans","year":"2024","journal-title":"Eur Heart J"},{"key":"2026111002520284200_djag268-B20","doi-asserted-by":"publisher","first-page":"107307","DOI":"10.1016\/j.leukres.2023.107307","article-title":"Review of clonal hematopoiesis, subtypes and its role in neoplasia and different morbidities","volume":"130","author":"Younes","year":"2023","journal-title":"Leuk Res"},{"key":"2026111002520284200_djag268-B21","doi-asserted-by":"publisher","first-page":"e13376","DOI":"10.1111\/acel.13376","article-title":"Genetic associations for two biological age measures point to distinct aging phenotypes","volume":"20","author":"Kuo","year":"2021","journal-title":"Aging Cell"},{"key":"2026111002520284200_djag268-B22","doi-asserted-by":"publisher","first-page":"e2230690","DOI":"10.1001\/jamanetworkopen.2022.30690","article-title":"Association of unhealthy lifestyle and childhood adversity with acceleration of aging among UK Biobank participants","volume":"5","author":"Yang","year":"2022","journal-title":"JAMA Network Open"},{"key":"2026111002520284200_djag268-B23","doi-asserted-by":"publisher","first-page":"4921","DOI":"10.1038\/s41467-024-49283-0","article-title":"Heterogeneous associations of multiplexed environmental factors and multidimensional aging metrics","volume":"15","author":"Pu","year":"2024","journal-title":"Nat Commun"},{"key":"2026111002520284200_djag268-B24","doi-asserted-by":"publisher","first-page":"2301720","DOI":"10.1183\/13993003.01720-2023","article-title":"Associations of combined phenotypic ageing and genetic risk with incidence of chronic respiratory diseases in the UK Biobank: a prospective cohort study","volume":"63","author":"Wang","year":"2024","journal-title":"Eur Respir J"},{"key":"2026111002520284200_djag268-B25","doi-asserted-by":"publisher","first-page":"e1002718","DOI":"10.1371\/journal.pmed.1002718","article-title":"A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: a cohort study","volume":"15","author":"Liu","year":"2018","journal-title":"PLoS Med"},{"key":"2026111002520284200_djag268-B26","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1016\/j.jacc.2021.07.023","article-title":"Healthy sleep patterns and risk of incident arrhythmias","volume":"78","author":"Li","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"2026111002520284200_djag268-B27","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1016\/j.cmet.2024.06.004","article-title":"Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities","volume":"36","author":"Kim","year":"2024","journal-title":"Cell Metab"},{"key":"2026111002520284200_djag268-B28","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1093\/ije\/dym157","article-title":"Estimating interaction on an additive scale between continuous determinants in a logistic regression model","volume":"36","author":"Knol","year":"2007","journal-title":"Int J Epidemiol"},{"key":"2026111002520284200_djag268-B29","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s40520-024-02861-0","article-title":"Association of biological aging with prostate cancer: insights from the National Health and Nutrition Examination Survey","volume":"36","author":"Yin","year":"2024","journal-title":"Aging Clin Exp Res"},{"key":"2026111002520284200_djag268-B30","doi-asserted-by":"publisher","first-page":"e13229","DOI":"10.1111\/acel.13229","article-title":"Underlying features of epigenetic aging clocks in vivo and in vitro","volume":"19","author":"Liu","year":"2020","journal-title":"Aging Cell"},{"key":"2026111002520284200_djag268-B31","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1038\/s41591-023-02784-9","article-title":"Validation of biomarkers of aging","volume":"30","author":"Moqri","year":"2024","journal-title":"Nat Med"},{"key":"2026111002520284200_djag268-B32","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.1056\/NEJMoa2413361","article-title":"Tumor-infiltrating clonal hematopoiesis","volume":"392","author":"Pich","year":"2025","journal-title":"N Engl J Med"},{"key":"2026111002520284200_djag268-B33","doi-asserted-by":"publisher","first-page":"1990","DOI":"10.1016\/j.cell.2021.03.005","article-title":"The aging lung: physiology, disease, and immunity","volume":"184","author":"Schneider","year":"2021","journal-title":"Cell"},{"key":"2026111002520284200_djag268-B34","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s40572-021-00328-2","article-title":"Environmental exposures and lung aging: molecular mechanisms and implications for improving respiratory health","volume":"8","author":"Eckhardt","year":"2021","journal-title":"Curr Environ Health Rep"},{"key":"2026111002520284200_djag268-B35","doi-asserted-by":"publisher","first-page":"e1002827","DOI":"10.1371\/journal.pmed.1002827","article-title":"Associations of genetics, behaviors, and life course circumstances with a novel aging and healthspan measure: evidence from the Health and Retirement Study","volume":"16","author":"Liu","year":"2019","journal-title":"PLoS Med"},{"key":"2026111002520284200_djag268-B36","doi-asserted-by":"publisher","first-page":"E301","DOI":"10.1038\/s41586-024-08572-w","article-title":"Common and rare variant associations with clonal haematopoiesis phenotypes","volume":"612","author":"Kessler","year":"2022","journal-title":"Nature"},{"key":"2026111002520284200_djag268-B37","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.socscimed.2015.01.030","article-title":"Childhood and later life stressors and increased inflammatory gene expression at older ages","volume":"130","author":"Levine","year":"2015","journal-title":"Soc Sci Med"},{"key":"2026111002520284200_djag268-B38","doi-asserted-by":"publisher","first-page":"e1005622","DOI":"10.1371\/journal.pgen.1005622","article-title":"Disproportionate contributions of select genomic compartments and cell types to genetic risk for coronary artery disease","volume":"11","author":"Won","year":"2015","journal-title":"PLoS Genet"},{"key":"2026111002520284200_djag268-B39","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1182\/blood.2019000989","article-title":"Clonal hematopoiesis and nonhematologic disorders","volume":"136","author":"Jaiswal","year":"2020","journal-title":"Blood"},{"key":"2026111002520284200_djag268-B40","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/s41586-020-2819-2","article-title":"Inherited causes of clonal haematopoiesis in 97,691 whole genomes","volume":"586","author":"Bick","year":"2020","journal-title":"Nature"}],"container-title":["JNCI: Journal of the National Cancer Institute"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jnci\/advance-article-pdf\/doi\/10.1093\/jnci\/djag268\/70480962\/djag268.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jnci\/article-pdf\/118\/11\/2159\/70480962\/djag268.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jnci\/article-pdf\/118\/11\/2159\/70480962\/djag268.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T07:52:12Z","timestamp":1794297132000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnci\/article\/118\/11\/2159\/8751166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,4]]},"references-count":40,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,8,4]]},"published-print":{"date-parts":[[2026,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jnci\/djag268","relation":{},"ISSN":["0027-8874","1460-2105"],"issn-type":[{"value":"0027-8874","type":"print"},{"value":"1460-2105","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,11]]},"published":{"date-parts":[[2026,8,4]]}}}