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Tumors harboring ecDNA showed worse overall survival than tumors harboring other focal amplifications. A strong association with whole-genome doubling suggests most ecDNA reflects genomic instability in treatment-na\u00efve lung cancer.<\/jats:p>","DOI":"10.1093\/jnci\/djag273","type":"journal-article","created":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T12:03:13Z","timestamp":1785585793000},"source":"Crossref","is-referenced-by-count":1,"title":["Examining the role of extrachromosomal DNA in lung cancer"],"prefix":"10.1093","author":[{"given":"Azhar","family":"Khandekar","sequence":"first","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute , Bethesda, MD,","place":["United States"]},{"name":"Department of Cellular and Molecular Medicine, University of California San Diego , La Jolla, CA,","place":["United States"]},{"name":"Department of Bioengineering, University of California San Diego , La Jolla, CA,","place":["United States"]},{"name":"Moores Cancer Center, University of California San Diego , La Jolla, CA,","place":["United 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