{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T12:54:09Z","timestamp":1791636849887,"version":"4.3.4"},"reference-count":58,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To evaluate whether mental disorders identified before cancer diagnosis, within 1 year, or 2 to 5\u2009years after cancer diagnosis are associated with cancer-specific mortality, and whether patients with both prediagnosis and postdiagnosis disorders had the highest mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a cohort study of 22\u2009281 UK Biobank participants linked to cancer and death registries. Mental disorders were ascertained from inpatient and outpatient diagnoses and psychiatric prescriptions, and then categorized by period. We applied period-specific longitudinal inverse probability weighting to preserve early-period information and estimate time-specific effects, with treatment and death censoring weights to reduce confounding and survival bias. Weighted Cox models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) overall and by site (prostate, breast, colorectal, lung, and lymphoma). Additional models evaluated prediagnosis only, postdiagnosis only, and both prediagnosis and postdiagnosis disorders vs none.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over median 5.3-year follow-up, 6134 cancer-specific deaths occurred. Mental disorders were associated with higher overall cancer mortality: prediagnosis (HR =\u20091.19, 95% CI = 1.11 to 1.27), first year postdiagnosis (HR = 1.38, 95% CI = 1.26 to 1.51), and years 2 to 5 (HR = 2.19, 95% CI = 1.97 to 2.43). Associations were strongest and most consistent during years 2 to 5 across sites (HR = 1.58-2.27). Site-specific analyses additionally showed elevated hazards for prediagnosis and first-year disorders in lymphoma and first-year disorders in colorectal cancer. Patients with postdiagnosis mental disorders, regardless of prediagnosis status, had higher cancer mortality than those with prediagnosis disorders only or none.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Mental disorders were associated with cancer-specific mortality throughout the continuum, with the strongest associations in years 2 to 5 across multiple sites. Findings support routine mental health screening and intervention in survivorship care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jnci\/djag289","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:28:12Z","timestamp":1787837292000},"source":"Crossref","is-referenced-by-count":0,"title":["Timing of mental disorders in relation to cancer-specific mortality in cancer patients"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9727-7636","authenticated-orcid":false,"given":"Mingyi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Population Health, Stanford University School of Medicine , Stanford, CA,","place":["United States"]},{"name":"Department of Urology, Stanford University School of Medicine , Stanford, CA,","place":["United 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