{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:06:34Z","timestamp":1792785994994,"version":"4.5.0"},"reference-count":14,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Trond Mohn Foundation (C.S.), the Swedish Cancer Society (C.S., A.S.) and Swedish Br\u00f6stcancerf\u00f6rbundet","id":[{"id":"https:\/\/ror.org\/0527jb766","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Overtreatment of breast ductal carcinoma in situ (DCIS) remains a major clinical problem because clinicopathologic criteria are insufficient to define the invasive potential. We evaluated whether periductal stromal morphology in diagnostic hematoxylin-eosin sections is associated with invasive recurrence among 711 DCIS patients from the randomized SweDCIS trial who underwent breast-conserving surgery with or without radiotherapy. Two raters scored the proportion of DCIS ducts surrounded by myxoid stroma. Eighty patients developed ipsilateral invasive recurrence as the first event post-surgery. Cause-specific Cox regression revealed that an increase in myxoid stroma was associated with a higher risk of invasive recurrence (adjusted HR per 10% increase = 1.16, 95% CI = 1.04 to 1.28; P\u2009=\u2009.005). The 20-year cumulative incidence of invasive recurrence was more than doubled for lesions with at least 10% myxoid stroma compared with those with &amp;lt;10% myxoid stroma (15.7% vs 7.1%). Periductal myxoid stroma may be a simple histologic marker for the invasive potential of DCIS.<\/jats:p>","DOI":"10.1093\/jnci\/djag293","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:43:01Z","timestamp":1787312581000},"source":"Crossref","is-referenced-by-count":0,"title":["Periductal myxoid stroma identifies ductal carcinoma in situ at risk of invasive recurrence"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5514-3637","authenticated-orcid":false,"given":"Aglaia","family":"Schiza","sequence":"first","affiliation":[{"name":"Department of Immunology, Genetics and Pathology, Uppsala University , Uppsala,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria","family":"Thurfjell","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genetics and Pathology, Uppsala University , Uppsala,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5107-4550","authenticated-orcid":false,"given":"Erik","family":"Holmberg","sequence":"additional","affiliation":[{"name":"Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital , Gothenburg,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troy","family":"Bremer","sequence":"additional","affiliation":[{"name":"PreludeDx , Laguna Hills, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Micke","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genetics and Pathology, Uppsala University , Uppsala,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4841-2672","authenticated-orcid":false,"given":"Per","family":"Karlsson","sequence":"additional","affiliation":[{"name":"Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital , Gothenburg,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0130-7296","authenticated-orcid":false,"given":"Fredrik","family":"W\u00e4rnberg","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg , Gothenburg,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3783-7256","authenticated-orcid":false,"given":"Carina","family":"Strell","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genetics and Pathology, Uppsala University , Uppsala,","place":["Sweden"]},{"name":"Centre for Cancer Biomarkers CCBIO, Department of Clinical Medicine, University of Bergen , Bergen,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"2026091812120137300_djag293-B1","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.trecan.2019.05.005","article-title":"Avoiding overtreatment of ductal carcinoma in situ","volume":"5","author":"van der Borden","year":"2019","journal-title":"Trends 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