{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T20:26:09Z","timestamp":1793823969418,"version":"4.6.1"},"reference-count":48,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U10 CA180821"],"award-info":[{"award-number":["U10 CA180821"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U10 CA180882"],"award-info":[{"award-number":["U10 CA180882"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U24 CA196171"],"award-info":[{"award-number":["U24 CA196171"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Postoperative circulating tumor DNA (ctDNA) is a highly prognostic marker of residual disease among patients with stage III colon cancer, and physical activity has been associated with improved survival after curative resection. Whether physical activity predicts outcomes according to postoperative ctDNA status remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a post hoc analysis of Cancer and Leukemia Group B\/SWOG 80702, a phase III study evaluating adjuvant celecoxib vs placebo and 3 vs 6\u2009months of chemotherapy. Total physical activity volume was assessed using validated questionnaires and quantified in metabolic equivalent task hours per week (MET-h\/week). Circulating tumor DNA status was determined using a clinically validated, tumor-informed assay (Signatera, Natera, Inc.).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 763 patients (median follow-up = 6.0\u2009years), 32.3% were inactive (&amp;lt;3.0 MET-h\/week), 24.4% were highly active (\u226518.0), and 17.8% were ctDNA-positive. Among patients who were ctDNA-negative, moderate (adjusted hazard ratio [HR]\u2009=\u20090.58, 95% CI = 0.37 to 0.91) and high physical activity (HR = 0.49, 95% CI = 0.27 to 0.86) were associated with improved disease-free survival (DFS) compared with inactivity, with similar trends in overall survival (OS). Physical activity was not associated with DFS or OS in the ctDNA-positive subcohort (P\u2009&amp;gt;\u2009.05 for all), though interactions were not statistically significant. Among patients who were physically active (\u22659.0 MET-h\/week) and received adjuvant celecoxib, improved DFS was observed in ctDNA-negative (HR = 0.41, 95% CI = 0.22 to 0.77) and ctDNA-positive (referent: inactive, placebo; HR = 0.29, 95% CI = 0.15 to 0.57) subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Greater physical activity was associated with improved DFS among patients who were ctDNA-negative. Physical activity and adjuvant celecoxib were associated with favorable survival outcomes regardless of ctDNA status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial identifier<\/jats:title>\n                    <jats:p>ClinicalTrials.gov NCT01150045<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jnci\/djag342","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:08:29Z","timestamp":1789988909000},"source":"Crossref","is-referenced-by-count":0,"title":["Physical activity and molecular residual disease in stage III colon cancer: findings from Cancer and Leukemia Group B (Alliance)\/SWOG 80702"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9174-2215","authenticated-orcid":false,"given":"George Q","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Surgery, Brigham and Women\u2019s Hospital , Boston, MA,","place":["United 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