{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T18:37:46Z","timestamp":1792780666266,"version":"4.5.0"},"reference-count":11,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"MSK Core","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.1093\/jnci\/djag346","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T17:40:57Z","timestamp":1792777257000},"source":"Crossref","is-referenced-by-count":0,"title":["Preoperative gemcitabine versus 5-FU\u2013based chemotherapy: is there a standard of care?"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0831-2247","authenticated-orcid":false,"given":"David Herman","family":"Ilson","sequence":"first","affiliation":[{"name":"Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College , New York, NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,23]]},"reference":[{"key":"2026102313405388000_djag346-B1","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.1056\/NEJMoa1809775","article-title":"FOLFIRINOX or Gemcitabine as adjuvant therapy for pancreatic cancer","volume":"379","author":"Conroy","year":"2018","journal-title":"N Engl J Med"},{"key":"2026102313405388000_djag346-B2","doi-asserted-by":"publisher","first-page":"2316","DOI":"10.1200\/JCO-25-02520","article-title":"Adjuvant chemotherapy\u2009\u00b1\u2009chemoradiotherapy for adenocarcinoma of the pancreatic head: results of the radiotherapy random assignment of NRG Oncology\/RTOG 0848","volume":"44","author":"Abrams","year":"2026","journal-title":"J Clin Oncol"},{"key":"2026102313405388000_djag346-B3","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1200\/JCO.21.02233","article-title":"Neoadjuvant chemoradiotherapy versus upfront surgery for resectable and borderline resectable pancreatic cancer: long-term results of the Dutch randomized PREOPANC trial","volume":"40","author":"Versteijne","year":"2022","journal-title":"J Clin Oncol"},{"key":"2026102313405388000_djag346-B4","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1016\/S1470-2045(25)00363-8","article-title":"Neoadjuvant FOLFIRINOX versus neoadjuvant gemcitabine-based chemoradiotherapy in resectable and borderline resectable pancreatic cancer (PREOPANC-2): a multicentre, open-label, phase 3 randomised trial","volume":"26","author":"Janssen","year":"2025","journal-title":"Lancet Oncol"},{"key":"2026102313405388000_djag346-B5","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1001\/jamaoncol.2020.7328","article-title":"Efficacy of perioperative chemotherapy for resectable pancreatic adenocarcinoma: a phase 2 randomized clinical trial","volume":"7","author":"Sohal","year":"2021","journal-title":"JAMA Oncol"},{"key":"2026102313405388000_djag346-B6","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/s41416-025-03025-1","article-title":"Survival after neoadjuvant and induction FOLFIRINOX versus gemcitabine-nab-paclitaxel in patients with resected localised pancreatic adenocarcinoma: an international multicentre study","volume":"133","author":"Stoop","year":"2025","journal-title":"Br J Cancer"},{"key":"2026102313405388000_djag346-B7","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/S2468-1253(23)00405-3","article-title":"Neoadjuvant FOLFIRINOX versus upfront surgery for resectable pancreatic head cancer (NORPACT-1): a multicentre, randomised, phase 2 trial","volume":"9","author":"Labori","year":"2024","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"2026102313405388000_djag346-B8","doi-asserted-by":"publisher","first-page":"2945","DOI":"10.1016\/S0140-6736(25)01685-X","article-title":"Preoperative mFOLFIRINOX versus PAXG for stage I-III resectable and borderline resectable pancreatic ductal adenocarcinoma (PACT-21 CASSANDRA): results of the first randomisation analysis of a randomised, open-label, 2\u2009\u00d7\u20092 factorial phase 3 trial","volume":"406","author":"Reni","year":"2026","journal-title":"Lancet"},{"key":"2026102313405388000_djag346-B9","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djag235","article-title":"Benefit of adjuvant chemotherapy for resected pancreatic cancer following neoadjuvant FOLFIRINOX or Gemcitabine-Nab-paclitaxel: a multinational analysis","author":"Lopez-Lopez","year":"2026","journal-title":"J Natl Cancer Inst"},{"key":"2026102313405388000_djag346-B10","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/s41591-023-02760-3","article-title":"Lymph-node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: the phase 1 AMPLIFY-201 trial","volume":"30","author":"Pant","year":"2024","journal-title":"Nat Med"},{"key":"2026102313405388000_djag346-B11","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1056\/NEJMoa2605555","article-title":"Daraxonrasib or Chemotherapy in previously treated metastatic pancreatic cancer","volume":"395","author":"O\u2019Reilly","year":"2026","journal-title":"N Engl J Med"}],"container-title":["JNCI: Journal of the National Cancer Institute"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jnci\/advance-article-pdf\/doi\/10.1093\/jnci\/djag346\/72445811\/djag346.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jnci\/advance-article-pdf\/doi\/10.1093\/jnci\/djag346\/72445811\/djag346.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T17:40:57Z","timestamp":1792777257000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnci\/advance-article\/doi\/10.1093\/jnci\/djag346\/8994259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,23]]},"references-count":11,"URL":"https:\/\/doi.org\/10.1093\/jnci\/djag346","relation":{},"ISSN":["0027-8874","1460-2105"],"issn-type":[{"value":"0027-8874","type":"print"},{"value":"1460-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,23]]},"article-number":"djag346"}}