{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:52:31Z","timestamp":1777596751726,"version":"3.51.4"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,1,18]]},"DOI":"10.1093\/jnci\/djj012","type":"journal-article","created":{"date-parts":[[2006,1,17]],"date-time":"2006-01-17T22:22:59Z","timestamp":1137536579000},"page":"116-122","source":"Crossref","is-referenced-by-count":102,"title":["Population-Based Study of Changing Breast Cancer Risk in Icelandic BRCA2 Mutation Carriers, 1920\u20132000"],"prefix":"10.1093","volume":"98","author":[{"given":"Laufey","family":"Tryggvadottir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helgi","family":"Sigvaldason","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gudridur H.","family":"Olafsdottir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon G.","family":"Jonasson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thorvaldur","family":"Jonsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hrafn","family":"Tulinius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorunn E.","family":"Eyfj\u00f6rd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,1,18]]},"reference":[{"key":"key\n\t\t\t\t20171012211713_BIB1","doi-asserted-by":"crossref","unstructured":"Parkin DM, Pisani P, Ferlay J. Estimates of the worldwide incidence of 25 major cancers in 1990. \n            Int J Cancer1999\n            ;\n            80\n            :\n            827\n            \u201341.","DOI":"10.1002\/(SICI)1097-0215(19990315)80:6<827::AID-IJC6>3.0.CO;2-P"},{"key":"key\n\t\t\t\t20171012211713_BIB2","doi-asserted-by":"crossref","unstructured":"Pisani P, Parkin DM, Bray F, Ferlay J. Estimates of the worldwide mortality from 25 cancers in 1990. \n            Int J Cancer1999\n            ;\n            83\n            :\n            18\n            \u201329.","DOI":"10.1002\/(SICI)1097-0215(19990924)83:1<18::AID-IJC5>3.0.CO;2-M"},{"key":"key\n\t\t\t\t20171012211713_BIB3","doi-asserted-by":"crossref","unstructured":"Botha JL, Bray F, Sankila R, Parkin DM. Breast cancer incidence and mortality trends in 16 european countries. \n            Eur J Cancer2003\n            ;\n            39\n            :\n            1718\n            \u201329.","DOI":"10.1016\/S0959-8049(03)00118-7"},{"key":"key\n\t\t\t\t20171012211713_BIB4","unstructured":"Moller B, Fekjaer H, Hakulinen T, Tryggvadottir L, Storm HH, Talback M, et al. Prediction of cancer incidence in the nordic countries up to the year 2020. \n            Eur J Cancer Prev2002\n            ;\n            11\n             Suppl 1:\n            S1\n            \u201396."},{"key":"key\n\t\t\t\t20171012211713_BIB5","unstructured":"Tulinius H, Sigvaldason H, Olafsdottir G, Tryggvadottir L, Bjarnadottir K. Breast cancer incidence and familiality in iceland during 75 years from 1921 to 1995. \n            J Med Genet1999\n            ;\n            36\n            :\n            103\n            \u20137."},{"key":"key\n\t\t\t\t20171012211713_BIB6","doi-asserted-by":"crossref","unstructured":"Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K, Tavtigian S, et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. \n            Science1994\n            ;\n            266\n            :\n            66\n            \u201371.","DOI":"10.1126\/science.7545954"},{"key":"key\n\t\t\t\t20171012211713_BIB7","doi-asserted-by":"crossref","unstructured":"Wooster R, Bignell G, Lancaster J, Swift S, Seal S, Mangion J, et al. Identification of the breast cancer susceptibility gene BRCA2. \n            Nature1995\n            ;\n            378\n            :\n            789\n            \u201392.","DOI":"10.1038\/378789a0"},{"key":"key\n\t\t\t\t20171012211713_BIB8","doi-asserted-by":"crossref","unstructured":"Tavtigian SV, Simard J, Rommens J, Couch F, Shattuck-Eidens D, Neuhausen S, et al. The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds. \n            Nat Genet1996\n            ;\n            12\n            :\n            333\n            \u20137.","DOI":"10.1038\/ng0396-333"},{"key":"key\n\t\t\t\t20171012211713_BIB9","doi-asserted-by":"crossref","unstructured":"Bergthorsson JT, Jonasdottir A, Johannesdottir G, Arason A, Egilsson V, Gayther S, et al. Identification of a novel splice-site mutation of the BRCA1 gene in two breast cancer families: screening reveals low frequency in Icelandic breast cancer patients. \n            Hum Mutat1998\n            ;Suppl 1:\n            S195\n            \u20137.","DOI":"10.1002\/humu.1380110163"},{"key":"key\n\t\t\t\t20171012211713_BIB10","doi-asserted-by":"crossref","unstructured":"Thorlacius S, Olafsdottir G, Tryggvadottir L, Neuhausen S, Jonasson JG, Tavtigian SV, et al. A single BRCA2 mutation in male and female breast cancer families from iceland with varied cancer phenotypes. \n            Nat Genet1996\n            ;\n            13\n            :\n            117\n            \u20139.","DOI":"10.1038\/ng0596-117"},{"key":"key\n\t\t\t\t20171012211713_BIB11","unstructured":"Thorlacius S, Sigurdsson S, Bjarnadottir H, Olafsdottir G, Jonasson JG, Tryggvadottir L, et al. Study of a single BRCA2 mutation with high carrier frequency in a small population. \n            Am J Hum Genet1997\n            ;\n            60\n            :\n            1079\n            \u201384."},{"key":"key\n\t\t\t\t20171012211713_BIB12","unstructured":"Johannesdottir G, Gudmundsson J, Bergthorsson JT, Arason A, Agnarsson BA, Eiriksdottir G, et al. High prevalence of the 999del5 mutation in icelandic breast and ovarian cancer patients. \n            Cancer Res1996\n            ;\n            56\n            :\n            3663\n            \u20135."},{"key":"key\n\t\t\t\t20171012211713_BIB13","doi-asserted-by":"crossref","unstructured":"Tulinius H, Olafsdottir GH, Sigvaldason H, Arason A, Barkardottir RB, Egilsson V, et al. The effect of a single BRCA2 mutation on cancer in iceland. \n            J Med Genet2002\n            ;\n            39\n            :\n            457\n            \u201362.","DOI":"10.1136\/jmg.39.7.457"},{"key":"key\n\t\t\t\t20171012211713_BIB14","unstructured":"Easton DF, Ford D, Bishop DT. Breast and ovarian cancer incidence in BRCA1-mutation carriers. breast cancer linkage consortium. \n            Am J Hum Genet1995\n            ;\n            56\n            :\n            265\n            \u201371."},{"key":"key\n\t\t\t\t20171012211713_BIB15","doi-asserted-by":"crossref","unstructured":"Ford D, Easton DF, Stratton M, Narod S, Goldgar D, Devilee P, et al. Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. the breast cancer linkage consortium. \n            Am J Hum Genet1998\n            ;\n            62\n            :\n            676\n            \u201389.","DOI":"10.1086\/301749"},{"key":"key\n\t\t\t\t20171012211713_BIB16","doi-asserted-by":"crossref","unstructured":"Struewing JP, Hartge P, Wacholder S, Baker SM, Berlin M, McAdams M, et al. The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among ashkenazi jews. \n            N Engl J Med1997\n            ;\n            336\n            :\n            1401\n            \u20138.","DOI":"10.1056\/NEJM199705153362001"},{"key":"key\n\t\t\t\t20171012211713_BIB17","doi-asserted-by":"crossref","unstructured":"Thorlacius S, Struewing JP, Hartge P, Olafsdottir GH, Sigvaldason H, Tryggvadottir L, et al. Population-based study of risk of breast cancer in carriers of BRCA2 mutation. \n            Lancet1998\n            ;\n            352\n            :\n            1337\n            \u20139.","DOI":"10.1016\/S0140-6736(98)03300-5"},{"key":"key\n\t\t\t\t20171012211713_BIB18","doi-asserted-by":"crossref","unstructured":"Antoniou A, Pharoah PD, Narod S, Risch HA, Eyfjord JE, Hopper JL, et al. Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: a combined analysis of 22 studies. \n            Am J Hum Genet2003\n            ;\n            72\n            :\n            1117\n            \u201330.","DOI":"10.1086\/375033"},{"key":"key\n\t\t\t\t20171012211713_BIB19","doi-asserted-by":"crossref","unstructured":"King MC, Marks JH, Mandell JB; New York Breast Cancer Study Group. Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2. \n            Science2003\n            ;\n            302\n            :\n            643\n            \u20136.","DOI":"10.1126\/science.1088759"},{"key":"key\n\t\t\t\t20171012211713_BIB20","doi-asserted-by":"crossref","unstructured":"Wacholder S, Hartge P, Struewing JP, Pee D, McAdams M, Brody L, et al. The kin-cohort study for estimating penetrance. \n            Am J Epidemiol1998\n            ;\n            148\n            :\n            623\n            \u201330.","DOI":"10.1093\/aje\/148.7.623"},{"key":"key\n\t\t\t\t20171012211713_BIB21","unstructured":"Snaedal G. Cancer of the breast. A clinical study of treated and untreated patients in Iceland 1911\u20131955. \n            Acta Chir Scand1965\n            ;\n            90\n            :Suppl 338:\n            1\n            ."},{"key":"key\n\t\t\t\t20171012211713_BIB22","doi-asserted-by":"crossref","unstructured":"Bjarnason O, Day N, Snaedal G, Tulinius H. The effect of year of birth on the breast cancer age-incidence curve in iceland. \n            Int J Cancer1974\n            ;\n            13\n            :\n            689\n            \u201396.","DOI":"10.1002\/ijc.2910130513"},{"key":"key\n\t\t\t\t20171012211713_BIB23","unstructured":"Gretarsdottir S, Thorlacius S, Valgardsdottir R, Gudlaugsdottir S, Sigurdsson S, Steinarsdottir M, et al. BRCA2 and p53 mutations in primary breast cancer in relation to genetic instability. \n            Cancer Res1998\n            ;\n            58\n            :\n            859\n            \u201362."},{"key":"key\n\t\t\t\t20171012211713_BIB24","doi-asserted-by":"crossref","unstructured":"Sigurdsson S, Thorlacius S, Tomasson J, Tryggvadottir L, Benediktsdottir K, Eyfjord JE, et al. BRCA2 mutation in icelandic prostate cancer patients. \n            J Mol Med1997\n            ;\n            75\n            :\n            758\n            \u201361.","DOI":"10.1007\/s001090050162"},{"key":"key\n\t\t\t\t20171012211713_BIB25","doi-asserted-by":"crossref","unstructured":"Coleman M, Douglas A, Hermon C, Peto J. Cohort study analysis with a FORTRAN computer program. \n            Int J Epidemiol1986\n            ;\n            15\n            :\n            134\n            \u20137.","DOI":"10.1093\/ije\/15.1.134"},{"key":"key\n\t\t\t\t20171012211713_BIB26","unstructured":"Gebski V, Leung O, MacNeil D, Lunn D. Statistical package for interactive data analysis (SPIDA). version 6. New South Wales (Australia): Macquarie University of NSW; \n            1992\n            ."},{"key":"key\n\t\t\t\t20171012211713_BIB27","doi-asserted-by":"crossref","unstructured":"Clayton D, Schifflers E. Models for temporal variation in cancer rates I: Age-period and age-cohort models. \n            Stat Med1987\n            ;\n            6\n            :\n            449\n            \u201367.","DOI":"10.1002\/sim.4780060405"},{"key":"key\n\t\t\t\t20171012211713_BIB28","unstructured":"Statistics Iceland. Available at: \n            http:\/\/www.statice.is\n            ."},{"key":"key\n\t\t\t\t20171012211713_BIB29","doi-asserted-by":"crossref","unstructured":"Tryggvadottir L, Tulinius H, Larusdottir M. A decline and a halt in mean age at menarche in Iceland. \n            Ann Hum Biol1994\n            ;\n            21\n            :\n            179\n            \u201386.","DOI":"10.1080\/03014469400003202"},{"key":"key\n\t\t\t\t20171012211713_BIB30","doi-asserted-by":"crossref","unstructured":"Jernstrom H, Lerman C, Ghadirian P, Lynch HT, Weber B, Garber J, et al. Pregnancy and risk of early breast cancer in carriers of BRCA1 and BRCA2. \n            Lancet1999\n            ;\n            354\n            :\n            1846\n            \u201350.","DOI":"10.1016\/S0140-6736(99)04336-6"},{"key":"key\n\t\t\t\t20171012211713_BIB31","doi-asserted-by":"crossref","unstructured":"Johannsson O, Loman N, Borg A, Olsson H. Pregnancy-associated breast cancer in BRCA1 and BRCA2 germline mutation carriers. \n            Lancet1998\n            ;\n            352\n            :\n            1359\n            \u201360.","DOI":"10.1016\/S0140-6736(05)60750-7"},{"key":"key\n\t\t\t\t20171012211713_BIB32","doi-asserted-by":"crossref","unstructured":"Hartge P, Chatterjee N, Wacholder S, Brody LC, Tucker MA, Struewing JP. Breast cancer risk in Ashkenazi BRCA1\/2 mutation carriers: effects of reproductive history. \n            Epidemiology2002\n            ;\n            13\n            :\n            255\n            \u201361.","DOI":"10.1097\/00001648-200205000-00004"},{"key":"key\n\t\t\t\t20171012211713_BIB33","doi-asserted-by":"crossref","unstructured":"Tryggvadottir L, Olafsdottir EJ, Gudlaugsdottir S, Thorlacius S, Jonasson JG, Tulinius H, et al. BRCA2 mutation carriers, reproductive factors and breast cancer risk. \n            Breast Cancer Res2003\n            ;\n            5\n            :\n            R121\n            \u20138.","DOI":"10.1186\/bcr619"},{"key":"key\n\t\t\t\t20171012211713_BIB34","doi-asserted-by":"crossref","unstructured":"Jernstrom H, Lubinski J, Lynch HT, Ghadirian P, Neuhausen S, Isaacs C, et al. Breast-feeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. \n            J Natl Cancer Inst2004\n            ;\n            96\n            :\n            1094\n            \u20138.","DOI":"10.1093\/jnci\/djh211"},{"key":"key\n\t\t\t\t20171012211713_BIB35","doi-asserted-by":"crossref","unstructured":"Narod SA. Modifiers of risk of hereditary breast and ovarian cancer. \n            Nat Rev Cancer2002\n            ;\n            2\n            :\n            113\n            \u201323.","DOI":"10.1038\/nrc726"},{"key":"key\n\t\t\t\t20171012211713_BIB36","doi-asserted-by":"crossref","unstructured":"Ghadirian P, Lubinski J, Lynch H, Neuhausen SL, Weber B, Isaacs C, et al. Smoking and the risk of breast cancer among carriers of BRCA mutations. \n            Int J Cancer2004\n            ;\n            110\n            :\n            413\n            \u20136.","DOI":"10.1002\/ijc.20106"},{"key":"key\n\t\t\t\t20171012211713_BIB37","doi-asserted-by":"crossref","unstructured":"Duffy SW, Agbaje O, Tabar L, Vitak B, Bjurstam N, Bj\u00f6rneld L, et al. Overdiagnosis and overtreatment of breast cancer: Estimates of overdiagnosis from two trials of mammographic screening for breast cancer. \n            Breast Cancer Res2005\n            ;\n            7\n            :\n            258\n            \u201365.","DOI":"10.1186\/bcr1354"},{"key":"key\n\t\t\t\t20171012211713_BIB38","doi-asserted-by":"crossref","unstructured":"Moller B, Weedon-Fekjaer H, Hakulinen T, Tryggvadottir L, Storm HH, Talback M, et al. The influence of mammographic screening on national trends in breast cancer incidence. \n            Eur J Cancer Prev2005\n            ;\n            14\n            :\n            117\n            \u201328.","DOI":"10.1097\/00008469-200504000-00007"},{"key":"key\n\t\t\t\t20171012211713_BIB39","doi-asserted-by":"crossref","unstructured":"Mikaelsdottir EK, Valgeirsdottir S, Eyfjord JE, Rafnar T. The icelandic founder mutation BRCA2 999del5: analysis of expression. \n            Breast Cancer Res2004\n            ;\n            6\n            :\n            R284\n            \u201390.","DOI":"10.1186\/bcr785"},{"key":"key\n\t\t\t\t20171012211713_BIB40","doi-asserted-by":"crossref","unstructured":"Begg CB. On the use of familial aggregation in population-based case probands for calculating penetrance. \n            J Natl Cancer Inst2002\n            ;\n            94\n            :\n            1221\n            \u20136.","DOI":"10.1093\/jnci\/94.16.1221"}],"container-title":["JNCI: Journal of the National Cancer Institute"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jnci\/article-pdf\/98\/2\/116\/7687838\/djj012.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T01:24:12Z","timestamp":1507857852000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/jnci\/article\/98\/2\/116\/2521824\/PopulationBased-Study-of-Changing-Breast-Cancer"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,18]]},"references-count":40,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2006,1,18]]},"published-print":{"date-parts":[[2006,1,18]]}},"URL":"https:\/\/doi.org\/10.1093\/jnci\/djj012","relation":{},"ISSN":["1460-2105","0027-8874"],"issn-type":[{"value":"1460-2105","type":"electronic"},{"value":"0027-8874","type":"print"}],"subject":[],"published-other":{"date-parts":[[2006,1,18]]},"published":{"date-parts":[[2006,1,18]]}}}