{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:38:51Z","timestamp":1788514731549,"version":"build-2803163510"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1093\/jnci\/djn478","type":"journal-article","created":{"date-parts":[[2009,2,11]],"date-time":"2009-02-11T04:41:04Z","timestamp":1234327264000},"page":"248-255","source":"Crossref","is-referenced-by-count":125,"title":["Rituximab Maintenance for the Treatment of Patients With Follicular Lymphoma: Systematic Review and Meta-analysis of Randomized Trials"],"prefix":"10.1093","volume":"101","author":[{"given":"Liat","family":"Vidal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat","family":"Gafter-Gvili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Leibovici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Dreyling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Ghielmini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Fang","family":"Hsu Schmitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amos","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofer","family":"Shpilberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,2,18]]},"reference":[{"issue":"9383","key":"key\n\t\t\t\t20170715053344_bib1","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/S0140-6736(03)14110-4","article-title":"Long-term effect of a watch and wait policy versus immediate systemic treatment for asymptomatic advanced-stage non-Hodgkin lymphoma: a randomised controlled trial","volume":"362","author":"Ardeshna","year":"2003","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170715053344_bib2","first-page":"75","article-title":"Natural history of and therapy for the indolent non-Hodgkin's lymphomas","volume":"20","author":"Horning","year":"1993","journal-title":"Semin Oncol"},{"key":"key\n\t\t\t\t20170715053344_bib3","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD003805.pub2","article-title":"Chemotherapy plus rituximab versus chemotherapy alone for B-cell non-Hodgkin's lymphoma","volume":"4","author":"Schulz","year":"2007","journal-title":"Cochrane Database Syst Rev."},{"issue":"6","key":"key\n\t\t\t\t20170715053344_bib4","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1200\/JCO.2005.12.171","article-title":"Phase II trial of individualized rituximab dosing for patients with CD20-positive lymphoproliferative disorders","volume":"23","author":"Gordan","year":"2005","journal-title":"J Clin Oncol"},{"key":"key\n\t\t\t\t20170715053344_bib5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1053\/sonc.2002.30154","article-title":"Rituximab as first-line and maintenance therapy for patients with indolent non-Hodgkin's lymphoma: interim follow-up of a multicenter phase II trial","volume":"29","author":"Hainsworth","year":"2002","journal-title":"Semin Oncol"},{"issue":"12","key":"key\n\t\t\t\t20170715053344_bib6","doi-asserted-by":"crossref","first-page":"4416","DOI":"10.1182\/blood-2003-10-3411","article-title":"Prolonged treatment with rituximab in patients with follicular lymphoma significantly increases event-free survival and response duration compared with the standard weekly x 4 schedule","volume":"103","author":"Ghielmini","year":"2004","journal-title":"Blood"},{"issue":"5","key":"key\n\t\t\t\t20170715053344_bib7","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1001\/jama.1995.03520290060030","article-title":"Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials","volume":"273","author":"Schulz","year":"1995","journal-title":"JAMA"},{"issue":"4","key":"key\n\t\t\t\t20170715053344_bib8","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1200\/JCO.1999.17.4.1244","article-title":"Report of an international workshop to standardize response criteria for non-Hodgkin's lymphomas. NCI Sponsored International Working Group","volume":"17","author":"Cheson","year":"1999","journal-title":"J Clin Oncol"},{"issue":"5","key":"key\n\t\t\t\t20170715053344_bib9","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1200\/JCO.2006.09.2403","article-title":"Revised response criteria for malignant lymphoma","volume":"25","author":"Cheson","year":"2007","journal-title":"J Clin Oncol"},{"issue":"24","key":"key\n\t\t\t\t20170715053344_bib10","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1002\/(SICI)1097-0258(19981230)17:24<2815::AID-SIM110>3.0.CO;2-8","article-title":"Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints","volume":"17","author":"Parmar","year":"1998","journal-title":"Stat Med"},{"key":"key\n\t\t\t\t20170715053344_bib11","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1745-6215-8-16","article-title":"Practical methods for incorporating summary time-to-event data into meta-analysis","volume":"8","author":"Tierney","year":"2007","journal-title":"Trials"},{"issue":"3","key":"key\n\t\t\t\t20170715053344_bib12","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control Clin Trials"},{"issue":"7414","key":"key\n\t\t\t\t20170715053344_bib13","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"issue":"10","key":"key\n\t\t\t\t20170715053344_bib14","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1182\/blood-2006-05-021113","article-title":"Rituximab maintenance improves clinical outcome of relapsed\/resistant follicular non-Hodgkin lymphoma in patients both with and without rituximab during induction: results of a prospective randomized phase 3 intergroup trial","volume":"108","author":"van Oers","year":"2006","journal-title":"Blood"},{"issue":"6","key":"key\n\t\t\t\t20170715053344_bib15","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1200\/JCO.2005.12.191","article-title":"Maximizing therapeutic benefit of rituximab: maintenance therapy versus re-treatment at progression in patients with indolent non-Hodgkin's lymphoma\u2014a randomized phase II trial of the Minnie Pearl Cancer Research Network","volume":"23","author":"Hainsworth","year":"2005","journal-title":"J Clin Oncol"},{"issue":"13","key":"key\n\t\t\t\t20170715053344_bib16","doi-asserted-by":"crossref","first-page":"4003","DOI":"10.1182\/blood-2006-04-016725","article-title":"Maintenance therapy with rituximab leads to a significant prolongation of response duration after salvage therapy with a combination of rituximab, fludarabine, cyclophosphamide, and mitoxantrone (R-FCM) in patients with recurring and refractory follicular and mantle cell lymphomas: results of a prospective randomized study of the German Low Grade Lymphoma Study Group (GLSG)","volume":"108","author":"Forstpointner","year":"2006","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170715053344_bib17","first-page":"106","article-title":"Maintenance rituximab after CVP results in superior clinical outcome in advanced follicular lymphoma (FL): results of the E1496 Phase III Trial from the Eastern Cooperative Oncology Group and the Cancer and Leukemia Group B","author":"Hochster","year":"2005","journal-title":"Blood"},{"issue":"18S","key":"key\n\t\t\t\t20170715053344_bib18","first-page":"8004","article-title":"Cyclophosphamide and fludarabine (CF) in advanced indolent lymphoma: results from the ECOG\/CALGB intergroup E1496 trial","volume":"25","author":"Hochster","year":"2007","journal-title":"J Clin Oncol. (ASCO Annual Meeting Proceedings Part I)"},{"issue":"6","key":"key\n\t\t\t\t20170715053344_bib20","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1080\/10428190500473113","article-title":"Delayed-onset peripheral blood cytopenia after rituximab: frequency and risk factor assessment in a consecutive series of 77 treatments","volume":"47","author":"Cattaneo","year":"2006","journal-title":"Leuk Lymphoma"},{"issue":"1","key":"key\n\t\t\t\t20170715053344_bib21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1089\/152581603321210082","article-title":"Long-lasting hypogammaglobulinemia following rituximab administration for Epstein-Barr virus-related post-transplant lymphoproliferative disease preemptive therapy","volume":"12","author":"Castagnola","year":"2003","journal-title":"J Hematother Stem Cell Res"},{"issue":"1","key":"key\n\t\t\t\t20170715053344_bib22","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1080\/10428190701742506","article-title":"B-cell depletion for 2 years after autologous stem cell transplant for NHL induces prolonged hypogammaglobulinemia beyond the rituximab maintenance period","volume":"49","author":"Lim","year":"2008","journal-title":"Leuk Lymphoma"},{"issue":"2","key":"key\n\t\t\t\t20170715053344_bib23","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/sj.bmt.1704742","article-title":"Maintenance rituximab after autologous stem cell transplant for high-risk B-cell lymphoma induces prolonged and severe hypogammaglobulinemia","volume":"35","author":"Lim","year":"2005","journal-title":"Bone Marrow Transplant"},{"issue":"6","key":"key\n\t\t\t\t20170715053344_bib24","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/sj.bmt.1705463","article-title":"Adjuvant rituximab causes prolonged hypogammaglobulinaemia following autologous stem cell transplant for non-Hodgkin's lymphoma","volume":"38","author":"Shortt","year":"2006","journal-title":"Bone Marrow Transplant"},{"issue":"11","key":"key\n\t\t\t\t20170715053344_bib25","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V110.11.1288.1288","article-title":"Predictive factors to hypogammaglobulinemia and non-neutropenic infection complications after rituximab\/chemotherapy treatment","volume":"110","author":"Filanovsky","year":"2007","journal-title":"Blood"},{"issue":"17","key":"key\n\t\t\t\t20170715053344_bib26","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1001\/jama.294.17.2203","article-title":"Randomized trials stopped early for benefit: a systematic review","volume":"294","author":"Montori","year":"2005","journal-title":"JAMA"},{"issue":"9","key":"key\n\t\t\t\t20170715053344_bib27","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.jclinepi.2006.12.006","article-title":"Systematic reviewers neglect bias that results from trials stopped early for benefit","volume":"60","author":"Bassler","year":"2007","journal-title":"J Clin Epidemiol"},{"issue":"2","key":"key\n\t\t\t\t20170715053344_bib28","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ctrv.2006.10.005","article-title":"Rituximab in lymphoma: a systematic review and consensus practice guideline from Cancer Care Ontario","volume":"33","author":"Cheung","year":"2007","journal-title":"Cancer Treat Rev."},{"key":"key\n\t\t\t\t20170715053344_bib29"},{"key":"key\n\t\t\t\t20170715053344_bib30"},{"key":"key\n\t\t\t\t20170715053344_bib31"},{"key":"key\n\t\t\t\t20170715053344_bib32"},{"key":"key\n\t\t\t\t20170715053344_bib33"}],"container-title":["JNCI: Journal of the National Cancer Institute"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jnci\/article-pdf\/101\/4\/248\/18614394\/djn478.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T16:09:33Z","timestamp":1589558973000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnci\/article-lookup\/doi\/10.1093\/jnci\/djn478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":32,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2009,2,18]]},"published-print":{"date-parts":[[2009,2]]}},"URL":"https:\/\/doi.org\/10.1093\/jnci\/djn478","relation":{},"ISSN":["0027-8874","1460-2105"],"issn-type":[{"value":"0027-8874","type":"print"},{"value":"1460-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}