{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T20:36:23Z","timestamp":1778186183722,"version":"3.51.4"},"reference-count":71,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,1,16]]},"DOI":"10.1093\/jnci\/djs482","type":"journal-article","created":{"date-parts":[[2012,11,22]],"date-time":"2012-11-22T21:11:40Z","timestamp":1353618700000},"page":"130-140","source":"Crossref","is-referenced-by-count":53,"title":["Prospective Study of Family History and Colorectal Cancer Risk by Tumor LINE-1 Methylation Level"],"prefix":"10.1093","volume":"105","author":[{"given":"Shuji","family":"Ogino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiko","family":"Nishihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Lochhead","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Imamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Kuchiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teppei","family":"Morikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai","family":"Yamauchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyun","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi Rong","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruifang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory J.","family":"Kirkner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna","family":"Spiegelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey A.","family":"Meyerhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva S.","family":"Schernhammer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew T.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Giovannucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles S.","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,11,21]]},"reference":[{"issue":"12","key":"key\n\t\t\t\t20170702114440_CIT0001","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1093\/oxfordjournals.aje.a008890","article-title":"Family history and risk of colorectal cancer in the multiethnic population of Hawaii","volume":"144","author":"Le Marchand","year":"1996","journal-title":"Am J Epidemiol"},{"issue":"21","key":"key\n\t\t\t\t20170702114440_CIT0002","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1093\/jnci\/86.21.1618","article-title":"Family history of cancer and colon cancer risk: the Utah Population Database","volume":"86","author":"Slattery","year":"1994","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"key\n\t\t\t\t20170702114440_CIT0003","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.ejca.2005.09.023","article-title":"Relative and absolute risk of colorectal cancer for individuals with a family history: a meta-analysis","volume":"42","author":"Butterworth","year":"2006","journal-title":"Eur J Cancer"},{"issue":"10","key":"key\n\t\t\t\t20170702114440_CIT0004","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1111\/j.1572-0241.2001.04677.x","article-title":"A systematic review and meta-analysis of familial colorectal cancer risk","volume":"96","author":"Johns","year":"2001","journal-title":"Am J Gastroenterol"},{"issue":"25","key":"key\n\t\t\t\t20170702114440_CIT0005","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1056\/NEJM199412223312501","article-title":"A prospective study of family history and the risk of colorectal cancer","volume":"331","author":"Fuchs","year":"1994","journal-title":"N Engl J Med"},{"issue":"11","key":"key\n\t\t\t\t20170702114440_CIT0006","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1097\/GIM.0b013e3181f30e9e","article-title":"Population prevalence of familial cancer and common hereditary cancer syndromes. The 2005 California Health Interview Survey","volume":"12","author":"Scheuner","year":"2010","journal-title":"Genet Med"},{"issue":"5","key":"key\n\t\t\t\t20170702114440_CIT0007","doi-asserted-by":"crossref","first-page":"e38175","DOI":"10.1371\/journal.pone.0038175","article-title":"Colorectal cancer linkage on chromosomes 4q21, 8q13, 12q24, and 15q22","volume":"7","author":"Cicek","year":"2012","journal-title":"PLoS One"},{"issue":"8","key":"key\n\t\t\t\t20170702114440_CIT0008","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/modpathol.2012.62","article-title":"Gene discovery in familial cancer syndromes by exome sequencing: prospects for the elucidation of familial colorectal cancer type X","volume":"25","author":"Ku","year":"2012","journal-title":"Mod Pathol"},{"issue":"3","key":"key\n\t\t\t\t20170702114440_CIT0009","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0010065","article-title":"Cancer as a complex phenotype: pattern of cancer distribution within and beyond the nuclear family","volume":"1","author":"Amundadottir","year":"2004","journal-title":"PLoS Med"},{"issue":"5","key":"key\n\t\t\t\t20170702114440_CIT0010","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1053\/j.gastro.2010.01.035","article-title":"Aberrant DNA methylation in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency","volume":"138","author":"Goel","year":"2010","journal-title":"Gastroenterology"},{"issue":"10","key":"key\n\t\t\t\t20170702114440_CIT0011","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/nrg2640","article-title":"The impact of retrotransposons on human genome evolution","volume":"10","author":"Cordaux","year":"2009","journal-title":"Nat Rev Genet"},{"key":"key\n\t\t\t\t20170702114440_CIT0012","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1093\/jnci\/djn359","article-title":"A cohort study of tumoral LINE-1 hypomethylation and prognosis in colon cancer","volume":"100","author":"Ogino","year":"2008","journal-title":"J Natl Cancer Inst"},{"issue":"9","key":"key\n\t\t\t\t20170702114440_CIT0013","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1002\/cncr.25737","article-title":"DNA methylation predicts recurrence from resected stage III proximal colon cancer","volume":"117","author":"Ahn","year":"2011","journal-title":"Cancer"},{"issue":"11","key":"key\n\t\t\t\t20170702114440_CIT0014","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1245\/s10434-012-2410-7","article-title":"Clinical outcomes of patients with microsatellite-unstable colorectal carcinomas depend on L1 methylation level","volume":"19","author":"Rhee","year":"2012","journal-title":"Ann Surg Oncol"},{"issue":"5","key":"key\n\t\t\t\t20170702114440_CIT0015","doi-asserted-by":"crossref","first-page":"e399","DOI":"10.1371\/journal.pone.0000399","article-title":"LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability","volume":"2","author":"Estecio","year":"2007","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170702114440_CIT0016","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1002\/ijc.23470","article-title":"LINE-1 hypomethylation is inversely associated with microsatellite instability and CpG methylator phenotype in colorectal cancer","volume":"122","author":"Ogino","year":"2008","journal-title":"Int J Cancer"},{"issue":"21","key":"key\n\t\t\t\t20170702114440_CIT0017","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1056\/NEJMoa067208","article-title":"Aspirin and the risk of colorectal cancer in relation to the expression of COX-2","volume":"356","author":"Chan","year":"2007","journal-title":"New Engl J Med"},{"issue":"16","key":"key\n\t\t\t\t20170702114440_CIT0018","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1001\/jama.2011.513","article-title":"Association of CTNNB1","volume":"305","author":"Morikawa","year":"2011","journal-title":"JAMA"},{"issue":"4","key":"key\n\t\t\t\t20170702114440_CIT0019","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1097\/00001648-199007000-00011","article-title":"Recall bias in subjective reports of familial cancer","volume":"1","author":"Floderus","year":"1990","journal-title":"Epidemiology"},{"issue":"1","key":"key\n\t\t\t\t20170702114440_CIT0020","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/jnci\/djj005","article-title":"Reliability of self-reported family history of cancer in a large case-control study of lymphoma","volume":"98","author":"Chang","year":"2006","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"key\n\t\t\t\t20170702114440_CIT0021","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1001\/jama.2011.955","article-title":"Clinically relevant changes in family history of cancer over time","volume":"306","author":"Ziogas","year":"2011","journal-title":"JAMA"},{"issue":"2","key":"key\n\t\t\t\t20170702114440_CIT0022","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1001\/jama.2011.980","article-title":"Recording, interpreting, and updating the family history of cancer: implications for cancer prevention","volume":"306","author":"Acheson","year":"2011","journal-title":"JAMA"},{"issue":"6","key":"key\n\t\t\t\t20170702114440_CIT0023","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1136\/gutjnl-2011-300865","article-title":"Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum","volume":"61","author":"Yamauchi","year":"2012","journal-title":"Gut"},{"issue":"6","key":"key\n\t\t\t\t20170702114440_CIT0024","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1136\/gutjnl-2012-302014","article-title":"Colorectal cancer: a tale of two sides or a continuum?","volume":"61","author":"Yamauchi","year":"2012","journal-title":"Gut"},{"issue":"2","key":"key\n\t\t\t\t20170702114440_CIT0025","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2353\/jmoldx.2006.050135","article-title":"Precision and performance characteristics of bisulfite conversion and real-time PCR","volume":"8","author":"Ogino","year":"2006","journal-title":"J Mol Diagn"},{"issue":"2","key":"key\n\t\t\t\t20170702114440_CIT0026","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2353\/jmoldx.2010.090106","article-title":"Precision of pyrosequencing assay to measure LINE-1 methylation in colon cancer, normal colonic mucosa and peripheral blood cells","volume":"12","author":"Irahara","year":"2010","journal-title":"J Mol Diagn"},{"issue":"6","key":"key\n\t\t\t\t20170702114440_CIT0027","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1136\/gut.2009.183707","article-title":"Dietary folate, alcohol, and B vitamins in relation to LINE-1 hypomethylation in colon cancer","volume":"59","author":"Schernhammer","year":"2010","journal-title":"Gut"},{"key":"key\n\t\t\t\t20170702114440_CIT0028","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/1476-4598-9-125","article-title":"Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumors","volume":"9","author":"Baba","year":"2010","journal-title":"Mol Cancer"},{"issue":"7","key":"key\n\t\t\t\t20170702114440_CIT0029","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1136\/gut.2005.082933","article-title":"CpG island methylator phenotype","volume":"55","author":"Ogino","year":"2006","journal-title":"Gut"},{"issue":"7","key":"key\n\t\t\t\t20170702114440_CIT0030","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/ng1834","article-title":"CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer","volume":"38","author":"Weisenberger","year":"2006","journal-title":"Nat Genet"},{"issue":"11","key":"key\n\t\t\t\t20170702114440_CIT0031","doi-asserted-by":"crossref","first-page":"e3698","DOI":"10.1371\/journal.pone.0003698","article-title":"Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample","volume":"3","author":"Nosho","year":"2008","journal-title":"PLoS One"},{"issue":"1","key":"key\n\t\t\t\t20170702114440_CIT0032","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1136\/gut.2008.155473","article-title":"CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer","volume":"58","author":"Ogino","year":"2009","journal-title":"Gut"},{"issue":"6","key":"key\n\t\t\t\t20170702114440_CIT0033","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/jnci\/djq031","article-title":"Lifestyle factors and microsatellite instability in colorectal cancer: The evolving field of molecular pathological epidemiology","volume":"102","author":"Ogino","year":"2010","journal-title":"J Natl Cancer Inst"},{"issue":"3","key":"key\n\t\t\t\t20170702114440_CIT0034","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1136\/gut.2010.217182","article-title":"Molecular pathological epidemiology of colorectal neoplasia: an emerging transdisciplinary and interdisciplinary field","volume":"60","author":"Ogino","year":"2011","journal-title":"Gut"},{"issue":"6","key":"key\n\t\t\t\t20170702114440_CIT0035","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/ijc.10148","article-title":"Associations between family history of colorectal cancer and genetic alterations in tumors","volume":"97","author":"Slattery","year":"2002","journal-title":"Int J Cancer"},{"issue":"3","key":"key\n\t\t\t\t20170702114440_CIT0036","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1158\/1055-9965.EPI-08-0878","article-title":"The association of tumor microsatellite instability phenotype with family history of colorectal cancer","volume":"18","author":"Bapat","year":"2009","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"16","key":"key\n\t\t\t\t20170702114440_CIT0037","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1001\/jama.293.16.1979","article-title":"Lower cancer incidence in Amsterdam-I criteria families without mismatch repair deficiency: familial colorectal cancer type X","volume":"293","author":"Lindor","year":"2005","journal-title":"JAMA"},{"issue":"22","key":"key\n\t\t\t\t20170702114440_CIT0038","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1001\/jama.2011.743","article-title":"Cancer risks associated with germline mutations in MLH1, MSH2, and MSH6 genes in Lynch syndrome","volume":"305","author":"Bonadona","year":"2011","journal-title":"JAMA"},{"issue":"3","key":"key\n\t\t\t\t20170702114440_CIT0039","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/jnci\/djp473","article-title":"Risks of Lynch syndrome cancers for MSH6 mutation carriers","volume":"102","author":"Baglietto","year":"2010","journal-title":"J Natl Cancer Inst"},{"issue":"13","key":"key\n\t\t\t\t20170702114440_CIT0040","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1200\/JCO.2008.20.3364","article-title":"Implications of familial colorectal cancer risk profiles and microsatellite instability status","volume":"27","author":"Lubbe","year":"2009","journal-title":"J Clin Oncol"},{"issue":"2","key":"key\n\t\t\t\t20170702114440_CIT0041","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jmoldx.2011.11.001","article-title":"Relevance, pathogenesis, and testing algorithm for mismatch repair-defective colorectal carcinomas: a report of the Association for Molecular Pathology","volume":"14","author":"Funkhouser","year":"2012","journal-title":"J Mol Diagn"},{"issue":"9","key":"key\n\t\t\t\t20170702114440_CIT0042","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1038\/sj.onc.1208387","article-title":"Comprehensive characterization of HNPCC-related colorectal cancers reveals striking molecular features in families with no germline mismatch repair gene mutations","volume":"24","author":"Abdel-Rahman","year":"2005","journal-title":"Oncogene"},{"issue":"4","key":"key\n\t\t\t\t20170702114440_CIT0043","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1097\/EDE.0b013e31825583a0","article-title":"Assessing disease risk in genome-wide association studies using family history","volume":"23","author":"Ghosh","year":"2012","journal-title":"Epidemiology"},{"issue":"3","key":"key\n\t\t\t\t20170702114440_CIT0044","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1093\/nar\/gnh032","article-title":"A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements","volume":"32","author":"Yang","year":"2004","journal-title":"Nucleic Acids Res"},{"issue":"5618","key":"key\n\t\t\t\t20170702114440_CIT0045","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1126\/science.1083558","article-title":"Induction of tumors in mice by genomic hypomethylation","volume":"300","author":"Gaudet","year":"2003","journal-title":"Science"},{"issue":"38","key":"key\n\t\t\t\t20170702114440_CIT0046","doi-asserted-by":"crossref","first-page":"13580","DOI":"10.1073\/pnas.0506612102","article-title":"Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis","volume":"102","author":"Yamada","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"17","key":"key\n\t\t\t\t20170702114440_CIT0047","doi-asserted-by":"crossref","first-page":"8462","DOI":"10.1158\/0008-5472.CAN-06-0293","article-title":"Chromosomal instability correlates with genome-wide DNA demethylation in human primary colorectal cancers","volume":"66","author":"Rodriguez","year":"2006","journal-title":"Cancer Res"},{"issue":"12","key":"key\n\t\t\t\t20170702114440_CIT0048","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/nrgastro.2011.173","article-title":"Epigenetics and colorectal cancer","volume":"8","author":"Lao","year":"2011","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"5","key":"key\n\t\t\t\t20170702114440_CIT0049","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1586\/erm.12.39","article-title":"Epigenetic biomarkers in colorectal cancer diagnostics","volume":"12","author":"Rawson","year":"2012","journal-title":"Expert Rev Mol Diagn"},{"issue":"6989","key":"key\n\t\t\t\t20170702114440_CIT0050","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/nature02536","article-title":"Transcriptional disruption by the L1 retrotransposon and implications for mammalian transcriptomes","volume":"429","author":"Han","year":"2004","journal-title":"Nature"},{"issue":"3","key":"key\n\t\t\t\t20170702114440_CIT0051","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/sj.onc.1210631","article-title":"Activation and transposition of endogenous retroviral elements in hypomethylation induced tumors in mice","volume":"27","author":"Howard","year":"2008","journal-title":"Oncogene"},{"issue":"3","key":"key\n\t\t\t\t20170702114440_CIT0052","doi-asserted-by":"crossref","first-page":"e17934","DOI":"10.1371\/journal.pone.0017934","article-title":"Hypomethylation of intragenic LINE-1 represses transcription in cancer cells through AGO2","volume":"6","author":"Aporntewan","year":"2011","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170702114440_CIT0053","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s13148-011-0032-8","article-title":"Long interspersed nuclear element-1 hypomethylation in cancer: biology and clinical applications","volume":"2","author":"Kitkumthorn","year":"2012","journal-title":"Clin Epigenet"},{"issue":"3","key":"key\n\t\t\t\t20170702114440_CIT0054","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s10552-009-9464-2","article-title":"Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer","volume":"21","author":"Hazra","year":"2010","journal-title":"Cancer Causes Control"},{"issue":"4","key":"key\n\t\t\t\t20170702114440_CIT0055","first-page":"1072","article-title":"Lifestyle factors and colorectal cancer microsatellite instability: molecular pathological epidemiology science, based on unique tumour principle","volume":"41","author":"Ogino","year":"2012","journal-title":"In J Epidemiol"},{"issue":"6","key":"key\n\t\t\t\t20170702114440_CIT0056","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1586\/erm.12.46","article-title":"How many molecular subtypes? Implications of the unique tumor principle in personalized medicine","volume":"12","author":"Ogino","year":"2012","journal-title":"Expert Rev Mol Diagn"},{"key":"key\n\t\t\t\t20170702114440_CIT0057","doi-asserted-by":"crossref","DOI":"10.4061\/2011\/902674","article-title":"CpG island methylation in colorectal cancer: past, present and future","author":"Curtin","year":"2011","journal-title":"Pathol Res Int"},{"issue":"1","key":"key\n\t\t\t\t20170702114440_CIT0058","first-page":"77","article-title":"The CpG island methylator phenotype in colorectal cancer: progress and problems","volume":"1825","author":"Hughes","year":"2012","journal-title":"Biochim Biophys Acta"},{"issue":"16","key":"key\n\t\t\t\t20170702114440_CIT0059","first-page":"4805","article-title":"Association of the CpG island methylator phenotype with family history of cancer in patients with colorectal cancer","volume":"63","author":"Frazier","year":"2003","journal-title":"Cancer Res"},{"issue":"20","key":"key\n\t\t\t\t20170702114440_CIT0060","doi-asserted-by":"crossref","first-page":"7618","DOI":"10.1158\/0008-5472.CAN-03-3978","article-title":"The CpG island methylator phenotype is not associated with a personal or family history of cancer","volume":"64","author":"Ward","year":"2004","journal-title":"Cancer Res"},{"issue":"12","key":"key\n\t\t\t\t20170702114440_CIT0061","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/nrclinonc.2011.122","article-title":"Cancer immunology-analysis of host and tumor factors for personalized medicine","volume":"8","author":"Ogino","year":"2011","journal-title":"Nat Rev Clin Oncol"},{"issue":"23","key":"key\n\t\t\t\t20170702114440_CIT0062","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1093\/jnci\/djj468","article-title":"Association of smoking, CpG island methylator phenotype, and V600E BRAF mutations in colon cancer","volume":"98","author":"Samowitz","year":"2006","journal-title":"J Natl Cancer Inst"},{"issue":"11","key":"key\n\t\t\t\t20170702114440_CIT0063","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1093\/jnci\/djs207","article-title":"Physical activity, biomarkers, and disease outcomes in cancer survivors: a systematic review","volume":"104","author":"Ballard-Barbash","year":"2012","journal-title":"J Natl Cancer Inst"},{"issue":"14","key":"key\n\t\t\t\t20170702114440_CIT0064","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1093\/jnci\/djq201","article-title":"Cigarette smoking and colorectal cancer risk by molecularly defined subtypes","volume":"102","author":"Limsui","year":"2010","journal-title":"J Natl Cancer Inst"},{"issue":"6","key":"key\n\t\t\t\t20170702114440_CIT0065","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/jnci\/djq011","article-title":"Case-control study of overweight, obesity, and colorectal cancer risk, overall and by tumor microsatellite instability status","volume":"102","author":"Campbell","year":"2010","journal-title":"J Natl Cancer Inst"},{"issue":"5","key":"key\n\t\t\t\t20170702114440_CIT0066","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1093\/jnci\/djr542","article-title":"Body mass index and risk of colorectal cancer according to fatty acid synthase expression in the Nurses\u2019 Health Study","volume":"104","author":"Kuchiba","year":"2012","journal-title":"J Natl Cancer Inst"},{"issue":"10","key":"key\n\t\t\t\t20170702114440_CIT0067","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1093\/jnci\/djr114","article-title":"Confirmation of family cancer history reported in a population-based survey","volume":"103","author":"Mai","year":"2011","journal-title":"J Natl Cancer Inst"},{"issue":"12","key":"key\n\t\t\t\t20170702114440_CIT0068","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1001\/jama.292.12.1480","article-title":"Does this patient have a family history of cancer? An evidence-based analysis of the accuracy of family cancer history","volume":"292","author":"Murff","year":"2004","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20170702114440_CIT0069","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.6004\/jnccn.2011.0137","article-title":"NCCN Task Force report: evaluating the clinical utility of tumor markers in oncology","volume":"9","author":"Febbo","year":"2011","journal-title":"J Natl Compr Canc Netw"},{"issue":"9","key":"key\n\t\t\t\t20170702114440_CIT0070","doi-asserted-by":"crossref","first-page":"e45357","DOI":"10.1371\/journal.pone.0045357","article-title":"A high degree of LINE-1 hypomethylation is a unique feature of early-onset colorectal cancer","volume":"7","author":"Antelo","year":"2012","journal-title":"PLoS One"},{"issue":"5","key":"key\n\t\t\t\t20170702114440_CIT0071","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1053\/j.gastro.2009.08.002","article-title":"A prospective cohort study shows unique epigenetic, genetic, and prognostic features of synchronous colorectal cancers","volume":"137","author":"Nosho","year":"2009","journal-title":"Gastroenterology"}],"container-title":["JNCI: Journal of the National Cancer Institute"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jnci\/article-pdf\/105\/2\/130\/17985352\/djs482.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T07:48:51Z","timestamp":1503474531000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnci\/article-lookup\/doi\/10.1093\/jnci\/djs482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,21]]},"references-count":71,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,11,21]]},"published-print":{"date-parts":[[2013,1,16]]}},"URL":"https:\/\/doi.org\/10.1093\/jnci\/djs482","relation":{},"ISSN":["1460-2105","0027-8874"],"issn-type":[{"value":"1460-2105","type":"electronic"},{"value":"0027-8874","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11,21]]}}}