{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T04:38:34Z","timestamp":1793248714834,"version":"4.5.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1093\/jnci\/dju016","type":"journal-article","created":{"date-parts":[[2014,2,25]],"date-time":"2014-02-25T05:01:47Z","timestamp":1393304507000},"source":"Crossref","is-referenced-by-count":83,"title":["A Prospective Study of Macrophage Inhibitory Cytokine-1 (MIC-1\/GDF15) and Risk of Colorectal Cancer"],"prefix":"10.1093","volume":"106","author":[{"given":"Raaj S.","family":"Mehta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navya","family":"Bezawada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kana","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xabier","family":"Garcia-Albeniz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teppei","family":"Morikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles S.","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Ogino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward L.","family":"Giovannucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,2,24]]},"reference":[{"issue":"4","key":"key\n\t\t\t\t20170521003544_CIT0001","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1002\/1097-0142(20010215)91:4<854::AID-CNCR1073>3.0.CO;2-Z","article-title":"Cancer risk in patients with inflammatory bowel disease: a population-based study","volume":"91","author":"Bernstein","year":"2001","journal-title":"Cancer"},{"issue":"6","key":"key\n\t\t\t\t20170521003544_CIT0002","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1001\/jama.2009.1112","article-title":"Aspirin use and survival after diagnosis of colorectal cancer","volume":"302","author":"Chan","year":"2009","journal-title":"JAMA"},{"issue":"1","key":"key\n\t\t\t\t20170521003544_CIT0003","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1053\/j.gastro.2007.09.035","article-title":"Aspirin dose and duration of use and risk of colorectal cancer in men","volume":"134","author":"Chan","year":"2008","journal-title":"Gastroenterology"},{"issue":"8","key":"key\n\t\t\t\t20170521003544_CIT0004","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1001\/jama.294.8.914","article-title":"Long-term use of aspirin and nonsteroidal anti-inflammatory drugs and risk of colorectal cancer","volume":"294","author":"Chan","year":"2005","journal-title":"JAMA"},{"issue":"6","key":"key\n\t\t\t\t20170521003544_CIT0005","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/onc.2009.421","article-title":"The role of COX-2 in intestinal inflammation and colorectal cancer","volume":"29","author":"Wang","year":"2010","journal-title":"Oncogene"},{"issue":"21","key":"key\n\t\t\t\t20170521003544_CIT0006","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1056\/NEJMoa067208","article-title":"Aspirin and the risk of colorectal cancer in relation to the expression of COX-2","volume":"356","author":"Chan","year":"2007","journal-title":"N Engl J Med"},{"issue":"5","key":"key\n\t\t\t\t20170521003544_CIT0007","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.bcp.2012.11.025","article-title":"The diverse roles of nonsteroidal anti-inflammatory drug activated gene (NAG-1\/GDF15) in cancer","volume":"85","author":"Wang","year":"2013","journal-title":"Biochem Pharmacol"},{"issue":"5","key":"key\n\t\t\t\t20170521003544_CIT0008","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3109\/08977194.2011.607137","article-title":"The TGF-\u03b2 superfamily cytokine, MIC-1\/GDF15: a pleotrophic cytokine with roles in inflammation, cancer and metabolism","volume":"29","author":"Breit","year":"2011","journal-title":"Growth Factors"},{"issue":"9324","key":"key\n\t\t\t\t20170521003544_CIT0009","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1016\/S0140-6736(02)09093-1","article-title":"Concentration in plasma of macrophage inhibitory cytokine-1 and risk of cardiovascular events in women: a nested case-control study","volume":"359","author":"Brown","year":"2002","journal-title":"Lancet"},{"issue":"7","key":"key\n\t\t\t\t20170521003544_CIT0010","first-page":"2642","article-title":"MIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinoma","volume":"9","author":"Brown","year":"2003","journal-title":"Clin Cancer Res"},{"issue":"10","key":"key\n\t\t\t\t20170521003544_CIT0011","doi-asserted-by":"crossref","first-page":"4983","DOI":"10.1158\/0008-5472.CAN-05-4067","article-title":"Role of macrophage inhibitory cytokine-1 in tumorigenesis and diagnosis of cancer","volume":"66","author":"Bauskin","year":"2006","journal-title":"Cancer Res"},{"issue":"2","key":"key\n\t\t\t\t20170521003544_CIT0012","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1158\/1055-9965.EPI-11-0786","article-title":"Serum macrophage inhibitory cytokine-1 (MIC-1\/GDF15): a potential screening tool for the prevention of colon cancer?","volume":"21","author":"Brown","year":"2012","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"4","key":"key\n\t\t\t\t20170521003544_CIT0013","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00432-009-0691-4","article-title":"Loss of GDF-15 abolishes sulindac chemoprevention in the ApcMin\/+ mouse model of intestinal cancer","volume":"136","author":"Zimmers","year":"2010","journal-title":"J Cancer Res Clin Oncol"},{"issue":"1","key":"key\n\t\t\t\t20170521003544_CIT0014","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1158\/1940-6207.CAPR-10-0196","article-title":"The role of NAG-1\/GDF15 in the inhibition of intestinal polyps in APC\/Min mice by sulindac","volume":"4","author":"Wang","year":"2011","journal-title":"Cancer Prev Res"},{"issue":"5","key":"key\n\t\t\t\t20170521003544_CIT0015","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1053\/j.gastro.2006.09.015","article-title":"Nonsteroidal anti-inflammatory drug-activated gene-1 over expression in transgenic mice suppresses intestinal neoplasia","volume":"131","author":"Baek","year":"2006","journal-title":"Gastroenterology"},{"issue":"3","key":"key\n\t\t\t\t20170521003544_CIT0016","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1053\/j.gastro.2010.11.041","article-title":"Inflammatory markers are associated with risk of colorectal cancer and chemopreventive response to anti-inflammatory drugs","volume":"140","author":"Chan","year":"2011","journal-title":"Gastroenterology"},{"issue":"9","key":"key\n\t\t\t\t20170521003544_CIT0017","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1038\/bjc.2013.172","article-title":"A prospective study of plasma inflammatory markers and risk of colorectal cancer in men","volume":"108","author":"Song","year":"2013","journal-title":"Br J Cancer"},{"issue":"17","key":"key\n\t\t\t\t20170521003544_CIT0018","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1093\/jnci\/87.17.1297","article-title":"Alcohol, height, and adiposity in relation to estrogen and prolactin levels in postmenopausal women","volume":"87","author":"Hankinson","year":"1995","journal-title":"J Natl Cancer Inst"},{"issue":"4","key":"key\n\t\t\t\t20170521003544_CIT0019","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1158\/1055-9965.EPI-05-0820","article-title":"C-peptide, insulin-like growth factor binding protein-1, glycosylated hemoglobin, and the risk of distal colorectal adenoma in women","volume":"15","author":"Wei","year":"2006","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"22","key":"key\n\t\t\t\t20170521003544_CIT0020","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1093\/jnci\/dji376","article-title":"Low plasma adiponectin levels and risk of colorectal cancer in men: a prospective study","volume":"97","author":"Wei","year":"2005","journal-title":"J Natl Cancer Inst"},{"issue":"3","key":"key\n\t\t\t\t20170521003544_CIT0021","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1002\/jcp.22196","article-title":"Divergent molecular mechanisms underlying the pleiotropic functions of macrophage inhibitory cytokine-1 in cancer","volume":"224","author":"Mimeault","year":"2010","journal-title":"J Cell Phys"},{"issue":"4","key":"key\n\t\t\t\t20170521003544_CIT0022","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/oxfordjournals.aje.a010013","article-title":"Underestimation of risk associations due to regression dilution in long-term follow-up of prospective studies","volume":"150","author":"Clarke","year":"1999","journal-title":"Am J Epidemiol"}],"container-title":["JNCI: Journal of the National Cancer Institute"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jnci\/article-pdf\/106\/4\/dju016\/17313367\/dju016.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T14:27:21Z","timestamp":1503498441000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnci\/article-lookup\/doi\/10.1093\/jnci\/dju016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,24]]},"references-count":22,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,2,24]]},"published-print":{"date-parts":[[2014,4]]}},"URL":"https:\/\/doi.org\/10.1093\/jnci\/dju016","relation":{},"ISSN":["1460-2105","0027-8874"],"issn-type":[{"value":"1460-2105","type":"electronic"},{"value":"0027-8874","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2,24]]}}}