{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:49:05Z","timestamp":1788497345626,"version":"build-2803163510"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1093\/jnci\/djv033","type":"journal-article","created":{"date-parts":[[2015,3,19]],"date-time":"2015-03-19T00:34:28Z","timestamp":1426725268000},"source":"Crossref","is-referenced-by-count":161,"title":["Breast Cancer Risk After Salpingo-Oophorectomy in Healthy BRCA1\/2 Mutation Carriers: Revisiting the Evidence for Risk Reduction"],"prefix":"10.1093","volume":"107","author":[{"given":"B. A. M.","family":"Heemskerk-Gerritsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Seynaeve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. J.","family":"van Asperen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. G. E. M.","family":"Ausems","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Coll\u00e9e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. C.","family":"van Doorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. B.","family":"Gomez Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. M.","family":"Kets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. E.","family":"van Leeuwen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. E. J.","family":"Meijers-Heijboer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J. E.","family":"Mourits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. A. M.","family":"van Os","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. F. A.","family":"Vasen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Verhoef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Rookus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Hooning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,3,18]]},"reference":[{"key":"key\n\t\t\t\t20170521013112_CIT0001","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1086\/301749","article-title":"Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium","volume":"62","author":"Ford","year":"1998","journal-title":"Am J Human Gen"},{"issue":"20","key":"key\n\t\t\t\t20170521013112_CIT0002","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1056\/NEJM199705153362001","article-title":"The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews","volume":"336","author":"Struewing","year":"1997","journal-title":"New Engl J Med"},{"issue":"9337","key":"key\n\t\t\t\t20170521013112_CIT0003","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0140-6736(02)11023-3","article-title":"Risk of ovarian cancer in breast-cancer patients with a family history of breast or ovarian cancer: a population-based cohort study","volume":"360","author":"Bergfeldt","year":"2002","journal-title":"Lancet"},{"issue":"5645","key":"key\n\t\t\t\t20170521013112_CIT0004","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1126\/science.1088759","article-title":"Grp NYBCS. Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2","volume":"302","author":"King","year":"2003","journal-title":"Science"},{"issue":"12","key":"key\n\t\t\t\t20170521013112_CIT0005","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1200\/JCO.2004.04.033","article-title":"Contralateral breast cancer in BRCA1 and BRCA2 mutation carriers","volume":"22","author":"Metcalfe","year":"2004","journal-title":"J Clin Oncol"},{"issue":"9","key":"key\n\t\t\t\t20170521013112_CIT0006","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1200\/JCO.2003.09.052","article-title":"Use of genetic testing and prophylactic mastectomy and oophorectomy in women with breast or ovarian cancer from families with a BRCA1 or BRCA2 mutation","volume":"21","author":"Meijers-Heijboer","year":"2003","journal-title":"J Clin Oncol"},{"issue":"3","key":"key\n\t\t\t\t20170521013112_CIT0007","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/GIM.0b013e318163487d","article-title":"Uptake and timing of bilateral prophylactic salpingo-oophorectomy among BRCA1 and BRCA2 mutation carriers","volume":"10","author":"Bradbury","year":"2008","journal-title":"Genet Med"},{"issue":"8","key":"key\n\t\t\t\t20170521013112_CIT0008","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1158\/1055-9965.EPI-09-0171","article-title":"Uptake of Risk-Reducing Surgery in Unaffected Women at High Risk of Breast and Ovarian Cancer Is Risk, Age, and Time Dependent","volume":"18","author":"Evans","year":"2009","journal-title":"Cancer Epidem Biomar"},{"issue":"1","key":"key\n\t\t\t\t20170521013112_CIT0009","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1089\/gtmb.2008.0067","article-title":"Uptake, time course, and predictors of risk-reducing surgeries in BRCA carriers","volume":"13","author":"Beattie","year":"2009","journal-title":"Genet Test Mol Biom"},{"issue":"4","key":"key\n\t\t\t\t20170521013112_CIT0010","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/j.1399-0004.2009.01329.x","article-title":"Risk-reducing mastectomy and salpingo-oophorectomy in unaffected BRCA mutation carriers: uptake and timing*","volume":"77","author":"Skytte","year":"2010","journal-title":"Clin Genet"},{"issue":"2","key":"key\n\t\t\t\t20170521013112_CIT0011","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.ygyno.2013.12.014","article-title":"Risk management options elected by women after testing positive for a BRCA mutation","volume":"132","author":"Garcia","year":"2014","journal-title":"Gynecol Oncol"},{"issue":"2","key":"key\n\t\t\t\t20170521013112_CIT0012","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.ygyno.2005.01.024","article-title":"Outcome of surveillance and prophylactic salpingo-oophorectomy in asymptomatic women at high risk for ovarian cancer","volume":"97","author":"Meeuwissen","year":"2005","journal-title":"Gynecol Oncol"},{"issue":"9","key":"key\n\t\t\t\t20170521013112_CIT0013","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1038\/sj.bjc.6603725","article-title":"No efficacy of annual gynaecological screening in BRCA1\/2 mutation carriers; an observational follow-up study","volume":"96","author":"Hermsen","year":"2007","journal-title":"Br J Cancer"},{"issue":"9","key":"key\n\t\t\t\t20170521013112_CIT0014","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1136\/jmg.2008.058248","article-title":"Screening for familial ovarian cancer: poor survival of BRCA1\/2 related cancers","volume":"46","author":"Evans","year":"2009","journal-title":"J Med Genet"},{"key":"key\n\t\t\t\t20170521013112_CIT0015","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1093\/jnci\/djn442","article-title":"Meta-analysis of risk reduction estimates associated with risk-reducing salpingo-oophorectomy in BRCA1 or BRCA2 mutation carriers","volume":"101","author":"Rebbeck","year":"2009","journal-title":"J Natl Cancer Inst"},{"issue":"17","key":"key\n\t\t\t\t20170521013112_CIT0016","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1093\/jnci\/91.17.1475","article-title":"Breast cancer risk after bilateral prophylactic oophorectomy in BRCA1 mutation carriers","volume":"91","author":"Rebbeck","year":"1999","journal-title":"J Natl Cancer Inst"},{"issue":"21","key":"key\n\t\t\t\t20170521013112_CIT0017","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1056\/NEJMoa012158","article-title":"Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations","volume":"346","author":"Rebbeck","year":"2002","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170521013112_CIT0018","doi-asserted-by":"crossref","first-page":"7491","DOI":"10.1200\/JCO.2004.00.7138","article-title":"Breast cancer risk following bilateral oophorectomy in BRCA1 and BRCA2 mutation carriers: an international case-control study","volume":"23","author":"Eisen","year":"2005","journal-title":"J Clin Oncol"},{"issue":"34","key":"key\n\t\t\t\t20170521013112_CIT0019","doi-asserted-by":"crossref","first-page":"8629","DOI":"10.1200\/JCO.2005.02.9199","article-title":"Prophylactic oophorectomy reduces breast cancer penetrance during prospective, long-term follow-up of BRCA1 mutation carriers","volume":"23","author":"Kramer","year":"2005","journal-title":"J Clin Oncol"},{"issue":"3","key":"key\n\t\t\t\t20170521013112_CIT0020","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1470-2045(06)70585-X","article-title":"Mortality after bilateral salpingo-oophorectomy in BRCA1 and BRCA2 mutation carriers: a prospective cohort study","volume":"7","author":"Domchek","year":"2006","journal-title":"Lancet Oncol"},{"issue":"8","key":"key\n\t\t\t\t20170521013112_CIT0021","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1200\/JCO.2007.13.9626","article-title":"Risk-reducing salpingo-oophorectomy for the prevention of BRCA1- and BRCA2-associated breast and gynecologic cancer: A multicenter, prospective study","volume":"26","author":"Kauff","year":"2008","journal-title":"J Clin Oncol"},{"issue":"9","key":"key\n\t\t\t\t20170521013112_CIT0022","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1001\/jama.2010.1237","article-title":"Association of Risk-Reducing Surgery in BRCA1 or BRCA2 Mutation Carriers With Cancer Risk and Mortality","volume":"304","author":"Domchek","year":"2010","journal-title":"J Am Med Assoc"},{"issue":"5","key":"key\n\t\t\t\t20170521013112_CIT0023","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1200\/JCO.2011.38.6060","article-title":"Online Tool to Guide Decisions for BRCA1\/2 Mutation Carriers","volume":"30","author":"Kurian","year":"2012","journal-title":"J Clin Oncol"},{"issue":"13","key":"key\n\t\t\t\t20170521013112_CIT0024","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1093\/jnci\/95.13.941","article-title":"Potential for bias in studies on efficacy of prophylactic surgery for BRCA1 and BRCA2 mutation","volume":"95","author":"Klaren","year":"2003","journal-title":"J Natl Cancer Inst"},{"issue":"16","key":"key\n\t\t\t\t20170521013112_CIT0025","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1093\/jnci\/djh229","article-title":"Bias in Intervention Studies That Enroll Patients From High-Risk Clinics","volume":"96","author":"Wacholder","year":"2004","journal-title":"J Natl Cancer Inst"},{"issue":"1","key":"key\n\t\t\t\t20170521013112_CIT0026","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s10549-009-0476-0","article-title":"Physical activity and the risk of breast cancer in BRCA1\/2 mutation carriers","volume":"120","author":"Pijpe","year":"2010","journal-title":"Breast Cancer Res Treat"},{"issue":"1","key":"key\n\t\t\t\t20170521013112_CIT0027","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/sim.4780030106","article-title":"A Non-Parametric Graphical Representation of the Relationship between Survival and the Occurrence of an Event - Application to Responder Versus Non-Responder Bias","volume":"3","author":"Simon","year":"1984","journal-title":"Stat Med"},{"issue":"2","key":"key\n\t\t\t\t20170521013112_CIT0028","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/mpr.124","article-title":"Graphing survival curve estimates for time-dependent covariates","volume":"11","author":"Schultz","year":"2002","journal-title":"Int J Meth Psych Res"},{"issue":"6","key":"key\n\t\t\t\t20170521013112_CIT0029","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.cellbi.2008.01.007","article-title":"Alterations of estrogen receptors, progesterone receptors and c-erbB2 oncogene protein expression in ductal carcinomas of the breast","volume":"32","author":"Hussein","year":"2008","journal-title":"Cell Biol Int"},{"issue":"15","key":"key\n\t\t\t\t20170521013112_CIT0030","first-page":"3197","article-title":"Altered estrogen receptor alpha and beta messenger RNA expression during human breast tumorigenesis","volume":"58","author":"Leygue","year":"1998","journal-title":"Cancer Res"},{"issue":"2","key":"key\n\t\t\t\t20170521013112_CIT0031","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/(SICI)1097-0142(19980715)83:2<310::AID-CNCR15>3.0.CO;2-W","article-title":"Steroid receptors in hereditary breast carcinomas associated with BRCA1 or BRCA2 mutations or unknown susceptibility genes","volume":"83","author":"Loman","year":"1998","journal-title":"Cancer"}],"container-title":["JNCI: Journal of the National Cancer Institute"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jnci\/article-pdf\/107\/5\/djv033\/17314430\/djv033.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T04:06:20Z","timestamp":1566446780000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnci\/article-lookup\/doi\/10.1093\/jnci\/djv033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,18]]},"references-count":31,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,3,18]]},"published-print":{"date-parts":[[2015,5]]}},"URL":"https:\/\/doi.org\/10.1093\/jnci\/djv033","relation":{},"ISSN":["1460-2105","0027-8874"],"issn-type":[{"value":"1460-2105","type":"electronic"},{"value":"0027-8874","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3,18]]}}}