{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:18:12Z","timestamp":1792181892007,"version":"4.4.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNCI J Natl Cancer Inst"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1093\/jnci\/djw182","type":"journal-article","created":{"date-parts":[[2016,8,31]],"date-time":"2016-08-31T02:04:13Z","timestamp":1472609053000},"page":"djw182","source":"Crossref","is-referenced-by-count":58,"title":["IGF-1R and mTOR Blockade: Novel Resistance Mechanisms and Synergistic Drug Combinations for Ewing Sarcoma"],"prefix":"10.1093","volume":"108","author":[{"given":"Salah-Eddine","family":"Lamhamedi-Cherradi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A.","family":"Menegaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vandhana","family":"Ramamoorthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deeksha","family":"Vishwamitra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L.","family":"Maywald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana S.","family":"Buford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela","family":"Fokt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislaw","family":"Skora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aung","family":"Naing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J.","family":"Lazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric M.","family":"Rohren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najat C.","family":"Daw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Subbiah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Benjamin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravin","family":"Ratan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waldemar","family":"Priebe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonios G.","family":"Mikos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesham M.","family":"Amin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Ludwig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,8,30]]},"reference":[{"key":"2016083019035634000_108.12.djw182.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.01.042"},{"key":"2016083019035634000_108.12.djw182.2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3389\/fcell.2015.00015","article-title":"Epigenetic reprogramming and re-differentiation of a Ewing sarcoma cell line","volume":"3","author":"Moore","year":"2015","journal-title":"Front Cell Dev Biol"},{"key":"2016083019035634000_108.12.djw182.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2014.10.004"},{"key":"2016083019035634000_108.12.djw182.4","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-009-0043-1"},{"key":"2016083019035634000_108.12.djw182.5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.6745"},{"key":"2016083019035634000_108.12.djw182.6","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.16.7275-7283.2004"},{"key":"2016083019035634000_108.12.djw182.7","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-0609"},{"key":"2016083019035634000_108.12.djw182.8","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-3220"},{"issue":"20","key":"2016083019035634000_108.12.djw182.9","first-page":"4570","article-title":"Insulin-like growth factor I receptor-mediated circuit in Ewing's sarcoma\/peripheral neuroectodermal tumor: a possible therapeutic target","volume":"56","author":"Scotlandi","year":"1996","journal-title":"Cancer Res."},{"key":"2016083019035634000_108.12.djw182.10","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-10-0719"},{"key":"2016083019035634000_108.12.djw182.11","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.34.0000"},{"key":"2016083019035634000_108.12.djw182.12","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-05-0068"},{"key":"2016083019035634000_108.12.djw182.13","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209990"},{"key":"2016083019035634000_108.12.djw182.14","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-2925"},{"key":"2016083019035634000_108.12.djw182.15","doi-asserted-by":"publisher","DOI":"10.1210\/me.2012-1142"},{"key":"2016083019035634000_108.12.djw182.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.01.007"},{"key":"2016083019035634000_108.12.djw182.17","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.640"},{"key":"2016083019035634000_108.12.djw182.18","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-14-0144"},{"key":"2016083019035634000_108.12.djw182.19","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-2274"},{"issue":"2","key":"2016083019035634000_108.12.djw182.20","first-page":"145","article-title":"mTOR inhibitors in sarcoma","volume":"9","author":"Demetri","year":"2011","journal-title":"Clin Adv Hematol Oncol."},{"key":"2016083019035634000_108.12.djw182.21","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207081"},{"key":"2016083019035634000_108.12.djw182.22","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.12-8-1007"},{"key":"2016083019035634000_108.12.djw182.23","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.7.12.6944"},{"key":"2016083019035634000_108.12.djw182.24","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21450"},{"key":"2016083019035634000_108.12.djw182.25","doi-asserted-by":"publisher","DOI":"10.1007\/s11523-009-0123-z"},{"key":"2016083019035634000_108.12.djw182.26","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-1693"},{"key":"2016083019035634000_108.12.djw182.27","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-0061"},{"key":"2016083019035634000_108.12.djw182.28","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70049-4"},{"key":"2016083019035634000_108.12.djw182.29","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25334"},{"key":"2016083019035634000_108.12.djw182.30","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-14-0334"},{"key":"2016083019035634000_108.12.djw182.31","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1221403110"},{"key":"2016083019035634000_108.12.djw182.32","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23157"},{"issue":"1","key":"2016083019035634000_108.12.djw182.33","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/pbc.22479","article-title":"R1507, a fully human monoclonal antibody targeting IGF-1R, is effective alone and in combination with rapamycin in inhibiting growth of osteosarcoma xenografts","volume":"55","author":"Kolb","year":"2010","journal-title":"Pediatr Blood Cancer."},{"key":"2016083019035634000_108.12.djw182.34","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.110.178400"},{"key":"2016083019035634000_108.12.djw182.35","unstructured":"Santoro M Lamhamedi-Cherradi Kasper FK, Ludwig JA Mikos AG. In Vitro Tumor Model Generated Using a Flow Perfusion Bioreactor. In BMES; 2013."},{"key":"2016083019035634000_108.12.djw182.36","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1506684112"},{"key":"2016083019035634000_108.12.djw182.37","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-2050"},{"key":"2016083019035634000_108.12.djw182.38","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.1021"},{"key":"2016083019035634000_108.12.djw182.39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018424"},{"key":"2016083019035634000_108.12.djw182.40","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-0371"},{"key":"2016083019035634000_108.12.djw182.41","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1008908107"},{"key":"2016083019035634000_108.12.djw182.42","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-0917"},{"key":"2016083019035634000_108.12.djw182.43","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djt263"},{"key":"2016083019035634000_108.12.djw182.44","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043384376"},{"key":"2016083019035634000_108.12.djw182.45","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-0945"},{"key":"2016083019035634000_108.12.djw182.46","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2005.03.033"},{"key":"2016083019035634000_108.12.djw182.47","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2013.509"}],"container-title":["Journal of the National Cancer Institute"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jnci\/article-pdf\/108\/12\/djw182\/18614596\/djw182.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T04:02:16Z","timestamp":1718769736000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnci\/article-lookup\/doi\/10.1093\/jnci\/djw182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,30]]},"references-count":47,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2016,8,30]]},"published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1093\/jnci\/djw182"],"URL":"https:\/\/doi.org\/10.1093\/jnci\/djw182","relation":{},"ISSN":["0027-8874","1460-2105"],"issn-type":[{"value":"0027-8874","type":"print"},{"value":"1460-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,30]]}}}