{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T09:43:43Z","timestamp":1793785423413,"version":"4.6.1"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T00:00:00Z","timestamp":1547769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100005190","name":"Melanoma Research Alliance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005190","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001582","name":"Dermatology Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001582","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Cancer Institute at the National Institutes of Health","award":["5P30CA082103"],"award-info":[{"award-number":["5P30CA082103"]}]},{"name":"National Cancer Institute at the National Institutes of Health","award":["1R35CA220481"],"award-info":[{"award-number":["1R35CA220481"]}]},{"name":"National Institute of Arthritis and Musculoskeletal"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24 AR069760"],"award-info":[{"award-number":["K24 AR069760"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acral melanoma is a rare type of melanoma that affects world populations irrespective of skin color and has worse survival than other cutaneous melanomas. It has relatively few single nucleotide mutations without the UV signature of cutaneous melanomas, but instead has a genetic landscape characterized by structural rearrangements and amplifications. BRAF mutations are less common than in other cutaneous melanomas, and knowledge about alternative therapeutic targets is incomplete.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To identify alternative therapeutic targets, we performed targeted deep-sequencing on 122 acral melanomas. We confirmed the loss of the tumor suppressors p16 and NF1 by immunohistochemistry in select cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In addition to BRAF (21.3%), NRAS (27.9%), and KIT (11.5%) mutations, we identified a broad array of MAPK pathway activating alterations, including fusions of BRAF (2.5%), NTRK3 (2.5%), ALK (0.8%), and PRKCA (0.8%), which can be targeted by available inhibitors. Inactivation of NF1 occurred in 18 cases (14.8%). Inactivation of the NF1 cooperating factor SPRED1 occurred in eight cases (6.6%) as an alternative mechanism of disrupting the negative regulation of RAS. Amplifications recurrently affected narrow loci containing PAK1 and GAB2 (n\u2009=\u200927, 22.1%), CDK4 (n\u2009=\u200927, 22.1%), CCND1 (n\u2009=\u200924, 19.7%), EP300 (n\u2009=\u200920, 16.4%), YAP1 (n\u2009=\u200915, 12.3%), MDM2 (n\u2009=\u200913, 10.7%), and TERT (n\u2009=\u200913, 10.7%) providing additional and possibly complementary therapeutic targets. Acral melanomas with BRAFV600E mutations harbored fewer genomic amplifications and were more common in patients with European ancestry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings support a new, molecularly based subclassification of acral melanoma with potential therapeutic implications: BRAFV600E mutant acral melanomas with characteristics similar to nonacral melanomas that could benefit from BRAF inhibitor therapy, and non-BRAFV600E mutant acral melanomas. Acral melanomas without BRAFV600E mutations harbor a broad array of therapeutically relevant alterations. Expanded molecular profiling would increase the detection of potentially targetable alterations for this subtype of acral melanoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jnci\/djz005","type":"journal-article","created":{"date-parts":[[2019,1,13]],"date-time":"2019-01-13T07:07:35Z","timestamp":1547363255000},"page":"1068-1077","source":"Crossref","is-referenced-by-count":175,"title":["Targeted Genomic Profiling of Acral Melanoma"],"prefix":"10.1093","volume":"111","author":[{"given":"Iwei","family":"Yeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Jorgenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengshu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey P","family":"North","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Hunter","family":"Shain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Reuss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Olshen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"von Deimling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pui-Yan","family":"Kwok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris C","family":"Bastian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam M","family":"Asgari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,1,18]]},"reference":[{"issue":"8","key":"2019101504345703000_djz005-B1","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1111\/ced.13243","article-title":"Acral melanoma foot lesions. Part 1: epidemiology, aetiology, and molecular pathology","volume":"42","author":"Desai","year":"2017","journal-title":"Clin Exp Dermatol"},{"issue":"4","key":"2019101504345703000_djz005-B2","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/j.1365-2133.2011.10772.x","article-title":"Melanoma of the hand and foot: epidemiological, prognostic and genetic features. A systematic review","volume":"166","author":"Durbec","year":"2012","journal-title":"Br J Dermatol"},{"issue":"11","key":"2019101504345703000_djz005-B3","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1245\/s10434-013-3089-0","article-title":"Prognosis of acral melanoma: a series of 281 patients","volume":"20","author":"Bello","year":"2013","journal-title":"Ann Surg Oncol"},{"issue":"2","key":"2019101504345703000_djz005-B4","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1101\/gr.125591.111","article-title":"Whole genome sequencing of matched primary and metastatic acral melanomas","volume":"22","author":"Turajlic","year":"2012","journal-title":"Genome Res"},{"issue":"20","key":"2019101504345703000_djz005-B5","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1056\/NEJMoa050092","article-title":"Distinct sets of genetic alterations in melanoma","volume":"353","author":"Curtin","year":"2005","journal-title":"N Engl J Med"},{"issue":"7653","key":"2019101504345703000_djz005-B6","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nature22071","article-title":"Whole-genome landscapes of major melanoma subtypes","volume":"545","author":"Hayward","year":"2017","journal-title":"Nature"},{"issue":"4","key":"2019101504345703000_djz005-B7","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1101\/gr.213348.116","article-title":"Integrated genomic analyses reveal frequent TERT aberrations in acral melanoma","volume":"27","author":"Liang","year":"2017","journal-title":"Genome Res"},{"issue":"1","key":"2019101504345703000_djz005-B8","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1146\/annurev-pathol-012513-104658","article-title":"The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia","volume":"9","author":"Bastian","year":"2014","journal-title":"Annu Rev Pathol Mech Dis"},{"issue":"5","key":"2019101504345703000_djz005-B9","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/pcmr.12129","article-title":"Identification of anaplastic lymphoma kinase break points and oncogenic mutation profiles in acral\/mucosal melanomas","volume":"26","author":"Niu","year":"2013","journal-title":"Pigment Cell Melanoma Res"},{"issue":"1","key":"2019101504345703000_djz005-B10","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/pcmr.12560","article-title":"Kinase gene fusions in defined subsets of melanoma","volume":"30","author":"Turner","year":"2017","journal-title":"Pigment Cell Melanoma Res"},{"issue":"8","key":"2019101504345703000_djz005-B11","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nrclinonc.2017.43","article-title":"Targeted agents and immunotherapies: optimizing outcomes in melanoma","volume":"14","author":"Luke","year":"2017","journal-title":"Nat Rev Clin Oncol"},{"issue":"14","key":"2019101504345703000_djz005-B12","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinforma Oxf Engl"},{"key":"2019101504345703000_djz005-B13"},{"issue":"9","key":"2019101504345703000_djz005-B14","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1101\/gr.107524.110","article-title":"The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data","volume":"20","author":"McKenna","year":"2010","journal-title":"Genome Res"},{"key":"2019101504345703000_djz005-B15","first-page":"1207.3907.","article-title":"Haplotype-based variant detection from short-read sequencing","author":"Garrison","year":"2012","journal-title":"arXiv"},{"issue":"18","key":"2019101504345703000_djz005-B16","doi-asserted-by":"crossref","first-page":"i333","DOI":"10.1093\/bioinformatics\/bts378","article-title":"DELLY: structural variant discovery by integrated paired-end and split-read analysis","volume":"28","author":"Rausch","year":"2012","journal-title":"Bioinformatics"},{"issue":"16","key":"2019101504345703000_djz005-B17","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1093\/nar\/gkq603","article-title":"ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data","volume":"38","author":"Wang","year":"2010","journal-title":"Nucleic Acids Res"},{"issue":"24","key":"2019101504345703000_djz005-B18","doi-asserted-by":"crossref","first-page":"3532","DOI":"10.1093\/bioinformatics\/btu651","article-title":"Quantifying tumor heterogeneity in whole-genome and whole-exome sequencing data","volume":"30","author":"Oesper","year":"2014","journal-title":"Bioinformatics"},{"issue":"4","key":"2019101504345703000_djz005-B19","doi-asserted-by":"crossref","first-page":"e1004873.","DOI":"10.1371\/journal.pcbi.1004873","article-title":"CNVkit: genome-wide copy number detection and visualization from targeted DNA sequencing","volume":"12","author":"Talevich","year":"2016","journal-title":"PLOS Comput Biol"},{"issue":"7571","key":"2019101504345703000_djz005-B20","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature15393","article-title":"A global reference for human genetic variation","volume":"526","author":"The 1000 Genomes Project Consortium","year":"2015","journal-title":"Nature"},{"issue":"9","key":"2019101504345703000_djz005-B21","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1101\/gr.094052.109","article-title":"Fast model-based estimation of ancestry in unrelated individuals","volume":"19","author":"Alexander","year":"2009","journal-title":"Genome Res"},{"issue":"8","key":"2019101504345703000_djz005-B22","doi-asserted-by":"crossref","first-page":"R72.","DOI":"10.1186\/gb-2011-12-8-r72","article-title":"TopHat-fusion: an algorithm for discovery of novel fusion transcripts","volume":"12","author":"Kim","year":"2011","journal-title":"Genome Biol"},{"issue":"4","key":"2019101504345703000_djz005-B23","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00401-014-1246-6","article-title":"Neurofibromin specific antibody differentiates malignant peripheral nerve sheath tumors (MPNST) from other spindle cell neoplasms","volume":"127","author":"Reuss","year":"2014","journal-title":"Acta Neuropathol"},{"issue":"6","key":"2019101504345703000_djz005-B24","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1111\/pcmr.12148","article-title":"Recurrent BRAF kinase fusions in melanocytic tumors offer an opportunity for targeted therapy","volume":"26","author":"Botton","year":"2013","journal-title":"Pigment Cell Melanoma Res"},{"issue":"4","key":"2019101504345703000_djz005-B25","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.neo.2015.03.004","article-title":"Development and validation of a scalable next-generation sequencing system for assessing relevant somatic variants in solid tumors","volume":"17","author":"Hovelson","year":"2015","journal-title":"Neoplasia N Y N"},{"key":"2019101504345703000_djz005-B26","doi-asserted-by":"crossref","first-page":"3116.","DOI":"10.1038\/ncomms4116","article-title":"Kinase fusions are frequent in Spitz tumours and spitzoid melanomas","volume":"5","author":"Wiesner","year":"2014","journal-title":"Nat Commun"},{"issue":"3","key":"2019101504345703000_djz005-B27","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/path.4775","article-title":"NTRK3 kinase fusions in Spitz tumours","volume":"240","author":"Yeh","year":"2016","journal-title":"J Pathol"},{"issue":"3","key":"2019101504345703000_djz005-B28","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1001\/jamadermatol.2015.2524","article-title":"Pigment-synthesizing melanocytic neoplasm with protein kinase C alpha (PRKCA) fusion","volume":"152","author":"Bahrami","year":"2016","journal-title":"JAMA Dermatol"},{"issue":"10","key":"2019101504345703000_djz005-B29","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1097\/PAS.0000000000000902","article-title":"Genomic analysis of pigmented epithelioid melanocytomas reveals recurrent alterations in PRKAR1A, and PRKCA genes","volume":"41","author":"Cohen","year":"2017","journal-title":"Am J Surg Pathol"},{"issue":"R2","key":"2019101504345703000_djz005-B30","doi-asserted-by":"crossref","first-page":"R123","DOI":"10.1093\/hmg\/ddw191","article-title":"Pathogenetics of the RASopathies","volume":"25","author":"Tidyman","year":"2016","journal-title":"Hum Mol Genet"},{"issue":"6418","key":"2019101504345703000_djz005-B31","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1126\/science.aau6509","article-title":"Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma","volume":"362","author":"Ablain","year":"2018","journal-title":"Science"},{"issue":"9","key":"2019101504345703000_djz005-B32","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1093\/jnci\/djt054","article-title":"P21-activated kinase 1 (PAK1) as a therapeutic target in BRAF wild-type melanoma","volume":"105","author":"Ong","year":"2013","journal-title":"J Natl Cancer Inst"},{"issue":"47","key":"2019101504345703000_djz005-B33","doi-asserted-by":"crossref","first-page":"19179","DOI":"10.1074\/jbc.M117.808063","article-title":"\u03b21 integrin\u2013dependent Rac\/group I PAK signaling mediates YAP activation of Yes-associated protein 1 (YAP1) via NF2\/merlin","volume":"292","author":"Sabra","year":"2017","journal-title":"J Biol Chem"},{"issue":"4","key":"2019101504345703000_djz005-B34","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.2353\/ajpath.2009.080543","article-title":"Gab2-mediated signaling promotes melanoma metastasis","volume":"174","author":"Horst","year":"2009","journal-title":"Am J Pathol"},{"issue":"21","key":"2019101504345703000_djz005-B35","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1101\/gad.1602907","article-title":"Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control","volume":"21","author":"Zhao","year":"2007","journal-title":"Genes Dev"},{"issue":"21","key":"2019101504345703000_djz005-B36","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1007\/s00018-012-1254-4","article-title":"Transcriptional\/epigenetic regulator CBP\/p300 in tumorigenesis: structural and functional versatility in target recognition","volume":"70","author":"Wang","year":"2013","journal-title":"Cell Mol Life Sci CMLS"},{"issue":"25","key":"2019101504345703000_djz005-B37","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1038\/sj.onc.1201298","article-title":"CBP\/p300 as a co-factor for the Microphthalmia transcription factor","volume":"14","author":"Sato","year":"1997","journal-title":"Oncogene"},{"issue":"38","key":"2019101504345703000_djz005-B38","doi-asserted-by":"crossref","first-page":"16275","DOI":"10.1073\/pnas.0904305106","article-title":"CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53","volume":"106","author":"Shi","year":"2009","journal-title":"Proc Natl Acad Sci"},{"issue":"6635","key":"2019101504345703000_djz005-B39","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/42981","article-title":"Binding and modulation of p53 by p300\/CBP coactivators","volume":"387","author":"Lill","year":"1997","journal-title":"Nature"},{"issue":"21","key":"2019101504345703000_djz005-B40","doi-asserted-by":"crossref","first-page":"4560","DOI":"10.1158\/0008-5472.CAN-15-0439","article-title":"Targeting the MDM2\/MDM4 interaction interface as a promising approach for p53 reactivation therapy","volume":"75","author":"Pellegrino","year":"2015","journal-title":"Cancer Res"},{"issue":"1","key":"2019101504345703000_djz005-B41","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/ng714","article-title":"Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53","volume":"29","author":"Parant","year":"2001","journal-title":"Nat Genet"},{"issue":"3","key":"2019101504345703000_djz005-B42","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.ccr.2014.07.014","article-title":"The somatic genomic landscape of chromophobe renal cell carcinoma","volume":"26","author":"Davis","year":"2014","journal-title":"Cancer Cell"},{"issue":"7575","key":"2019101504345703000_djz005-B43","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nature14980","article-title":"Telomerase activation by genomic rearrangements in high-risk neuroblastoma","volume":"526","author":"Peifer","year":"2015","journal-title":"Nature"},{"issue":"7","key":"2019101504345703000_djz005-B44","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/j.cell.2015.05.044","article-title":"Genomic classification of cutaneous melanoma","volume":"161","author":"Akbani","year":"2015","journal-title":"Cell"},{"issue":"2","key":"2019101504345703000_djz005-B45","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/bjd.15600","article-title":"Prognostic factors and survival in acral lentiginous melanoma","volume":"177","author":"Asgari","year":"2017","journal-title":"Br J Dermatol"},{"issue":"9","key":"2019101504345703000_djz005-B46","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1002\/1097-0142(19801101)46:9<2074::AID-CNCR2820460928>3.0.CO;2-K","article-title":"Subungual malignant melanoma: a clinical\u2014pathologic study","volume":"46","author":"Patterson","year":"1980","journal-title":"Cancer"},{"issue":"2","key":"2019101504345703000_djz005-B47","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.amjsurg.2007.03.010","article-title":"Subungual melanoma: management considerations","volume":"195","author":"Cohen","year":"2008","journal-title":"Am J Surg"},{"key":"2019101504345703000_djz005-B48","volume-title":"WHO Classification of Skin Tumours","author":"Elder","year":"2018","edition":"4th ed"},{"issue":"1","key":"2019101504345703000_djz005-B49","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ejca.2011.06.056","article-title":"Prevalence of BRAF V600E mutation in Chinese melanoma patients: large scale analysis of BRAF and NRAS mutations in a 432-case cohort","volume":"48","author":"Si","year":"2012","journal-title":"Eur J Cancer"},{"issue":"2","key":"2019101504345703000_djz005-B50","doi-asserted-by":"crossref","first-page":"195","DOI":"10.5021\/ad.2014.26.2.195","article-title":"Prognostic and clinicopathologic associations of BRAF mutation in primary acral lentiginous melanoma in Korean patients: a preliminary study","volume":"26","author":"Hong","year":"2014","journal-title":"Ann Dermatol"},{"issue":"11","key":"2019101504345703000_djz005-B51","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1111\/cup.12382","article-title":"Frequencies of KIT and GNAQ mutations in acral melanoma","volume":"41","author":"Puntervoll","year":"2014","journal-title":"J Cutan Pathol"},{"issue":"7","key":"2019101504345703000_djz005-B52","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1001\/archderm.1980.01640310043015","article-title":"Acral lentiginous melanoma","volume":"116","author":"Coleman","year":"1980","journal-title":"Arch Dermatol"},{"issue":"9","key":"2019101504345703000_djz005-B53","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/ng.3361","article-title":"Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas","volume":"47","author":"Krauthammer","year":"2015","journal-title":"Nat Genet"},{"issue":"26","key":"2019101504345703000_djz005-B54","doi-asserted-by":"crossref","first-page":"4340","DOI":"10.1200\/JCO.2006.06.2984","article-title":"Somatic activation of KIT in distinct subtypes of melanoma","volume":"24","author":"Curtin","year":"2006","journal-title":"J Clin Oncol"},{"issue":"8","key":"2019101504345703000_djz005-B55","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1056\/NEJMoa1714448","article-title":"Efficacy of larotrectinib in TRK fusion\u2013positive cancers in adults and children","volume":"378","author":"Drilon","year":"2018","journal-title":"N Engl J Med"},{"issue":"8","key":"2019101504345703000_djz005-B56","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1158\/0008-5472.CAN-13-2625","article-title":"Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence","volume":"74","author":"Nissan","year":"2014","journal-title":"Cancer Res"}],"container-title":["JNCI: Journal of the National Cancer Institute"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jnci\/article-pdf\/111\/10\/1068\/30120302\/djz005.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jnci\/article-pdf\/111\/10\/1068\/30120302\/djz005.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T05:01:21Z","timestamp":1571115681000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnci\/article\/111\/10\/1068\/5292473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,18]]},"references-count":56,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2019,1,18]]},"published-print":{"date-parts":[[2019,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jnci\/djz005","relation":{},"ISSN":["0027-8874","1460-2105"],"issn-type":[{"value":"0027-8874","type":"print"},{"value":"1460-2105","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,10]]},"published":{"date-parts":[[2019,1,18]]}}}